A short review on chitosan and gelatin-based hydrogel composite polymers for wound healing

Ebhodaghe, Samuel Ogbeide

doi:10.1080/09205063.2022.2068941

Cited by 29 publications

(16 citation statements)

References 181 publications

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“…The acute wounds healed with the F5 chitosan–mPEG hydrogel exhibited tensile strength near that of the standard group, which employed more breaking force to crack the reconstructed skin tissue. This finding is in agreement with the findings of wounds healed with chitosan and gelatin-based hydrogel …”

Section: Resultssupporting

confidence: 87%

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Injectable Chitosan–Methoxy Polyethylene Glycol Hybrid Hydrogel Untangling the Wound Healing Behavior: In Vitro and In Vivo Evaluation

Mushtaq,

Ashfaq,

Anwar

et al. 2023

ACS Omega

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Wound healing, particularly for difficult-to-treat wounds, presents a serious threat and may lead to complications. Currently available dressings lack mucoadhesion, safety, efficacy, and, most importantly, patient compliance. Herein, we developed a unique, simple, and inexpensive injectable chitosan−methoxy polyethylene glycol (chitosan−mPEG) hybrid hydrogel with tunable physicochemical and mechanical properties for wound healing. The detailed physicochemical and rheological characterization of the chitosan−mPEG hydrogel has revealed chemical interaction between available −NH 2 groups of chitosan and −COOH groups of mPEG acid, which, to our perspective, enhanced the mechanical and wound healing properties of hybrid chitosan and mPEG hydrogel compared to solo chitosan or PEG hydrogel. By introducing mPEG, the wound healing ability of hydrogel is synergistically improved due to its antibacterial feature, together with chitosan's innate role in hemostasis and wound closure. The detailed hemostasis and wound closure potential of the chitosan−mPEG hydrogel were investigated in a rat model, which confirmed a significant acceleration in wound healing and ultimately wound closure. In conclusion, the developed chitosan− mPEG hydrogel met all the required specifications and could be developed as a promising material for hemostasis, especially wound management, and as an excellent candidate for wound healing application.

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Section: Resultssupporting

confidence: 87%

“…This finding is in agreement with the findings of wounds healed with chitosan and gelatin-based hydrogel. 43 2.3.7. Histology Analysis.…”

Section: Measurement Of Tensile Strengthmentioning

confidence: 99%

Injectable Chitosan–Methoxy Polyethylene Glycol Hybrid Hydrogel Untangling the Wound Healing Behavior: In Vitro and In Vivo Evaluation

Mushtaq,

Ashfaq,

Anwar

et al. 2023

ACS Omega

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show abstract

“…CS plays an important role in all processes of hemostasis. During hemostasis, CS can induce the aggregation of platelets and plasma proteins to help the blood clotting and vasoconstriction at the injured site [ 64 , 65 , 66 , 67 ]. Moreover, CS has been found to enhance the function of polymorphonuclear leukocytes, macrophages, and fibroblasts [ 68 ].…”

Section: Hemostatic Mechanism Of Cs Hydrogelsmentioning

confidence: 99%

Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

et al. 2023

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The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hemostatic hydrogels have frequently been used for hemostasis due to their unique biocompatibility, tunable mechanical properties, injectability, and ease of handling. Moreover, chitosan (CS) absorbs red blood cells and activates platelets to promote hemostasis. Benefiting from these desired properties, the hemostatic application of CS hydrogels is attracting ever-increasing research attention. This paper reviews the recent research progress of CS-based hemostatic hydrogels and their advantageous characteristics compared to traditional hemostatic materials. The effects of the hemostatic mechanism, effects of deacetylation degree, relative molecular mass, and chemical modification on the hemostatic performance of CS hydrogels are summarized. Meanwhile, some typical applications of CS hydrogels are introduced to provide references for the preparation of efficient hemostatic hydrogels. Finally, the future perspectives of CS-based hemostatic hydrogels are presented.

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“…The introduction of different types of nanoparticles into hydrogel nanocomposites, such as carbon-based, polymer-based, inorganic and metal-based nanoparticles, is a common method to obtain nano-composite hydrogels with excellent properties and customized functions, which can not only enhance the mechanical properties, self-healing properties and chemical properties, but also improve their stability. 197 , 198 , 212 Therefore, multifunctional nanocomposites have a good application potentiality in the field of wound repair.…”

Section: Biological Nanomaterials For Skin Wound Repairmentioning

confidence: 99%

Recent Advances in Nano-Formulations for Skin Wound Repair Applications

Lin¹,

Chen²,

Liu³

et al. 2022

DDDT

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Skin injuries caused by accidents and acute or chronic diseases place a heavy burden on patients and health care systems. Current treatments mainly depend on preventing infection, debridement, and hemostasis and on supplementing growth factors, but patients will still have scar tissue proliferation or difficulty healing and other problems after treatment. Conventional treatment usually focuses on a single factor or process of wound repair and often ignores the influence of the wound pathological microenvironment on the final healing effect. Therefore, it is of substantial research value to develop multifunctional therapeutic methods that can actively regulate the wound microenvironment and reduce the oxidative stress level at the wound site to promote the repair of skin wounds. In recent years, various bioactive nanomaterials have shown great potential in tissue repair and regeneration due to their properties, including their unique surface interface effect, small size effect, enzyme activity and quantum effect. This review summarizes the mechanisms underlying skin wound repair and the defects in traditional treatment methods. We focus on analyzing the advantages of different types of nanomaterials and comment on their toxicity and side effects when used for skin wound repair.

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A short review on chitosan and gelatin-based hydrogel composite polymers for wound healing

Cited by 29 publications

References 181 publications

Injectable Chitosan–Methoxy Polyethylene Glycol Hybrid Hydrogel Untangling the Wound Healing Behavior: In Vitro and In Vivo Evaluation

Injectable Chitosan–Methoxy Polyethylene Glycol Hybrid Hydrogel Untangling the Wound Healing Behavior: In Vitro and In Vivo Evaluation

Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

Recent Advances in Nano-Formulations for Skin Wound Repair Applications

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