In this focused progress review, the most widely accepted methods of transdermal drug delivery are hypodermic needles, transdermal patches and topical creams. However, microneedles (MNs) (or microneedle arrays) are low-invasive 3D biomedical constructs that bypass the skin barrier and produce systemic and localized pharmacological effects. In the past, biomaterials such as carbohydrates, due to their physicochemical properties, have been extensively used to manufacture microneedles (MNs). Due to their wide range of functional groups, carbohydrates enable the design and development of tunable properties and functionalities. In recent years, numerous microneedle products have emerged on the market, although much research needs to be undertaken to overcome the various challenges before the successful introduction of microneedles into the market. As a result, carbohydrate-based microarrays have a high potential to achieve a future step in sensing, drug delivery, and biologics restitution. In this review, a comprehensive overview of carbohydrates such as hyaluronic acid, chitin, chitosan, chondroitin sulfate, cellulose and starch is discussed systematically. It also discusses the various drug delivery strategies and mechanical properties of biomaterial-based MNs, the progress made so far in the clinical translation of carbohydrate-based MNs, and the promotional opportunities for their commercialization. In conclusion, the article summarizes the future perspectives of carbohydrate-based MNs, which are considered as the new class of topical drug delivery systems.

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Since almond seed oil can be used for biodiesel production, this study is aimed at investigating the effect of different blend ratios on the fuel properties of almond biodiesel. The biodiesel was characterized for the properties of flash point, cloud point, pour point, viscosity, saponification value, peroxide value, acid value, iodine value, density and specific gravity using the Gas Chromatography Mass Spectrophotometer (GCMS). When blended with petrol diesel at ratios of 20%, 30% and 50%, results showed that the properties of the biodiesel obtained at a blend of 20% had properties more similar to the ASTM standard. At that proportion of 20%, the properties of acid value, viscosity, cloud point, pour point and iodine value were found to be 0.95meq/kg, 8.80Cp, 6 0 C, 1 0 C and 41.62gI2/100g respectively, except the flash point which was 72 0 C at biodiesel blend of 50%. This is because increase in blending ratios was found to result in corresponding increase of the properties.