A short review on pharmacological activity of Cissus quadrangularis

Sundaran, Jeganath; Begum, Raleena; Vasanthi, M; Kamalapathy, Manjalam; Bupesh, Giridharan; Sahoo, Uttamkumar

doi:10.6026/97320630016579

Cited by 27 publications

(10 citation statements)

References 14 publications

(8 reference statements)

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“…Several pharmacological properties of C. quadrangularisis have been reported, including anti-obesity, anti-diabetic, antioxidant, analgesic, anti-inflammatory, etc. [ 64 , 65 ]. Chidambaram et al [ 38 ] supplemented HFFD with CQEt at a 10 g/100 g diet to alleviate NALFD in the albino rat model.…”

Section: Discussionmentioning

confidence: 99%

Phytotherapy as Multi-Hit Therapy to Confront the Multiple Pathophysiology in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Experimental Interventions

Ore

Akinloye

2021

Medicina

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Non-alcoholic fatty liver disease (NAFLD), or metabolic dysfunction-associated fatty liver disease (MAFLD), is a metabolic condition distinguished by fat deposition in the hepatocytes. It has a prevalence of about 25% worldwide and is associated with other conditions such as diabetes mellitus, obesity, hypertension, etc. Background and Objectives: There is currently no approved drug therapy for NAFLD. Current measures in the management of NAFLD include lifestyle modification such as an increase in physical activity or weight loss. Development of NAFLD involves a number of parallel hits: including genetic predisposition, insulin resistance, disordered lipid metabolism, mitochondrial dysfunction, lipotoxicity, oxidative stress, etc. Herbal therapy may have a role to play in the treatment of NAFLD, due to their numerous bioactive constituents and the multiple pharmacological actions they exhibit. Therefore, this systematic review aims to investigate the potential multi-targeting effects of plant-derived extracts in experimental models of NAFLD. Materials and Methods: We performed a systematic search on databases and web search engines from the earliest available date to 30 April 2021, using relevant keywords. The study included articles published in English, assessing the effects of plant-derived extracts, fractions, or polyherbal mixtures in the treatment of NAFLD in animal models. These include their effects on at least disordered lipid metabolism, insulin resistance/type 2 diabetes mellitus (T2DM), and histologically confirmed steatosis with one or more of the following: oxidative stress, inflammation, hepatocyte injury, obesity, fibrosis, and cardiometabolic risks factors. Results: Nine articles fulfilled our inclusion criteria and the results demonstrated the ability of phytomedicines to simultaneously exert therapeutic actions on multiple targets related to NAFLD. Conclusions: These findings suggest that herbal extracts have the potential for effective treatment or management of NAFLD.

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Section: Discussionmentioning

confidence: 99%

Phytotherapy as Multi-Hit Therapy to Confront the Multiple Pathophysiology in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Experimental Interventions

Ore

Akinloye

2021

Medicina

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“…[8,28] Dihydrokaempferol, apigenin and naringenin were isolates of C. trifoliata stem extract. [29] The identified phenolic acids were gallic (2), protocatechuic (3), ferulic (6) and coumaric (10) acids. Ferulic and coumaric acids were isolates of C. trifoliata stem extract.…”

Section: Hplc-esi-ms/ms Analysismentioning

confidence: 99%

“…[5,6] Different Cissus species are frequently used by traditional healers to treat various health problems such as fever, fractured bones, ingestion, dyspepsia, kidney stones, and asthma. [7][8][9][10][11] The main active constituents of Cissus species are sterols, triterpenoids, alkaloids, phenolics, flavonoids, stilbene derivatives, coumarin glycosides and iridoids. [8,[12][13][14][15][16][17][18][19][20] Many pharmacological activities were attributed to certain Cissus species, such as antimicrobial, antiulcer, antiosteoporosis, hypoglycemic, antioxidant, antitumor, analgesic, anti-inflammatory, hepatoprotective, immunomodulatory, anti-obesity, antihyperlipidemic, estrogenic, anti-arthritic and anti-allergic activities.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling and Compound Isolation of Cissus rhombifolia Vahl. Leaves Aqueous Methanolic Extract with the Evaluation of Its Anti‐Inflammatory Effect Using Lipopolysaccharide‐Induced Inflammation in RAW 264.7 Cells

Raslan¹,

Mounier²

2023

Chemistry & Biodiversity

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The inflammatory disorders represent a serious health issue. Certain Cissus species possess anti-inflammatory effect. Cissus rhombifolia Vahl. leaves' anti-inflammatory activities and phytoconstituents are poorly characterized. In this study, 38 constituents were tentatively characterized in Cissus rhombifolia Vahl. leaves' aqueous methanolic extract (CRLE) using high-performance liquid chromatography combined with mass spectrometry (HPLC/MS) and Proton Nuclear Magnetic Resonance ( 1 H-NMR). Myricetin, β-amyrin, and alliospiroside A, were isolated from CRLE using column chromatography. The anti-inflammatory effect of CRLE and its isolated compounds were studied in lipopolysaccharide (LPS)-induced RAW 264.7 cells. 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT as-say) was used to assess how CRLE and its isolated compounds affected cell viability. Further, its effects on the production of intracellular NO, and inflammatory cytokines cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6) were assessed by the Griess test, and cytokine enzymelinked immunosorbent assays, respectively. CRLE and its isolated compounds, myricetin, β-amyrin, and alliospiroside A decreased the NO production. Western blotting was performed to assess the protein expression levels of the inflammatory cytokines inducible nitric oxide synthase (iNOS). Alliospiroside A downregulated IL-6, TNF-α, and COX-2 and inhibited the expression of iNOS. CRLE and its compounds represent effective alternative candidate to treat inflammatory diseases.

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“…Medicinal Properties: Anti-osteoporotic activity, Antioxidant and Antimicrobial activity, Antibacterial activity, Anticonvulsant and sedative activity, CNS Activity, Anti-anxiolytic and Antiepileptic, Anthelmintic activity 9,8,10,11,12,13 .…”

Section: Fig 1: Process Of Extract Preparationmentioning

confidence: 99%

Untitled

2022

IJPSR

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Alzheimer's disease is the most frequent cause of dementia worldwide and its incidence is increasing due to the world's aging population. Alzheimer's disease (AD) is one of the greatest medical care challenges of our century and is the main cause of dementia and neurodegenerative diseases. Dementia is defined as an acquired loss of cognition in many cognitive domains. Herbal medicine has evolved as the greatest option for the treatment of Alzheimer's disease due to its wide availability, low cost, high patient compliance, ease of formulation and lack of harmful side effects. Novel techniques can be used for the development of herbal medicine. In these research article animal studies, has been carried out to known Alzheimer disease (AD) caused by chemical compounds may be helpful in deeper understanding the mechanism of disease and AD treatment.In the present study, the efficacy of an ethanolic extract of Cissus quadrangularis stems (EECQ) was evaluated against scopolamine-induced Alzheimer's in the Wistar albino rat. As Cissus quadrangularis stems contain many active chemical constituents, including phenolic compounds, flavonoids, phytosterols, triterpenoids, Vitamin C, Tannins, and alkaloids, etc., serve as useful antioxidants are present in this plant. The Cissus quadrangularis stems were reported to have antioxidant properties. The stem of the Cissus quadrangularis contains carotene mainly β-carotene, which is responsible for showing the anti-Alzheimer's activity. The antioxidant potential is the best supplement for the diseases associated with oxidative stress. Hence, an attempt was made to evaluate the anti-Alzheimer activity from Cissus quadrangularis stems to extract. INTRODUCTION:Alzheimer's Disease: Dr. Alois Alzheimer, in 1906 he recognized the intellect of a woman who misplaced her life due to certain peculiar symptoms such as memory loss, unpredictable actions, cognitive disability and then concluded that the loss QUICK RESPONSE CODE

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A short review on pharmacological activity of Cissus quadrangularis

Cited by 27 publications

References 14 publications

Phytotherapy as Multi-Hit Therapy to Confront the Multiple Pathophysiology in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Experimental Interventions

Phytotherapy as Multi-Hit Therapy to Confront the Multiple Pathophysiology in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Experimental Interventions

Phytochemical Profiling and Compound Isolation of Cissus rhombifolia Vahl. Leaves Aqueous Methanolic Extract with the Evaluation of Its Anti‐Inflammatory Effect Using Lipopolysaccharide‐Induced Inflammation in RAW 264.7 Cells

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