A Short-Term Evaluation of the Relationship Between Plasma Ascorbic Acid Levels and Periodontal Disease in Systemically Healthy and Type 2 Diabetes Mellitus Subjects

Gokhale, Neeraja H.; Acharya, Anirudh B.; Patil, Vijay S.; Trivedi, Dheeraj J.; Thakur, Srinath

doi:10.3109/19390211.2013.790332

Cited by 48 publications

(72 citation statements)

References 31 publications

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“…From these 46 potential relevant articles, 31 did not meet the criteria. Finally, 15 publications (7 cross-sectional studies [23][24][25][26][27][28][29], 2 case-control studies [30,31], 2 cohort studies [32,33]), and 4 RCTs [34][35][36][37]) were selected for systematic review, as shown in the flow chart ( Figure 1). Excluding the RCTs, 6 of the remaining 11 studies estimated vitamin C intake from dietary investigation and 6 studies measured blood vitamin C concentration.…”

Section: Literature Searches and Study Characteristicsmentioning

confidence: 99%

Relationship between Vitamin C and Periodontal Diseases: A Systematic Review

Tada¹,

Miura²

2019

Preprint

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Vitamin C is important in preventing and slowing the progression of many diseases. There is significant evidence linking periodontal disease and vitamin C. We aimed to systematically review studies addressing the relationship between vitamin C and periodontal disease and the preventive ability of vitamin C against periodontal disease. Electric searches were performed using PubMed, EMBASE, Cochrane Library, and Web of Science. Studies addressing the relationships between periodontal disease and vitamin C in adults aged over 18 years were included. Quality assessment was done using Critical Appraisal Skills Program guideline and GRADE-CERQual. Seventy hundred and sixteen articles were retrieved and fifteen articles (7 cross-sectional studies, 2 case-control studies, 2 cohort studies, and 4 randomized controlled trial [RCT]) were selected by reviewing all articles. Vitamin C intake and blood level were negatively related to periodontal disease in all 7 cross-sectional studies. Subjects who suffer from periodontitis presented lower vitamin C intake and lower blood vitamin C level than subjects without periodontal disease in the two case-control studies. Patients with lower dietary intake or lower blood level of vitamin C showed greater progression of periodontal disease than did the controls. Intervention using vitamin C administration improved gingival bleeding in gingivitis but not in periodontitis. Alveolar bone absorption was also not improved. The present systematic review suggested that vitamin C contributes to reduced risk of periodontal disease.

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Section: Literature Searches and Study Characteristicsmentioning

confidence: 99%

Relationship between Vitamin C and Periodontal Diseases: A Systematic Review

Tada¹,

Miura²

2019

Preprint

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“…Akman et al [76] showed that the administration of vitamin C with or without alpha lipoic acid was associated with a significant decrease in serum myeloperoxidase levels, increased bone alkaline phosphatase levels, decreased alveolar bone resorption, and decreased RANKL-positive cell count. In individuals with chronic periodontitis, vitamin C intake in addition to nonsurgical periodontal treatment has been shown to decrease the gingival bleeding index levels [77]. Furthermore, it was reported that low serum levels of vitamin C and vitamin E may be risk factors for periodontal disease in elderly individuals [78].…”

Section: Vitamin Cmentioning

confidence: 99%

Antioxidants and Periodontal Diseases

Talmaç¹,

Çalışır²

2019

Gingival Disease - A Professional Approach for Treatment and Prevention

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Excessive reactive oxygen species production plays an important role in the pathogenesis of various chronic inflammatory diseases, including periodontal disease. Reactive oxygen species could damage the cells and the tissues. In the pathogenesis of periodontal diseases, the increased PMN count and activity cause a high rate of ROS release. This leads to increased oxidative stress in periodontal tissues. Periodontal tissues require adequate levels of antioxidants to prevent tissue damage caused by reactive oxygen species. The use of antioxidants in the treatment of periodontal disease and periodontal health has gained importance in recent studies. Antioxidants can be used to treat periodontal disease locally or systemically. Therefore, this chapter focuses on the effects of antioxidant on periodontal tissues.

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“…75 Kronik periodontitisli ve yeni tanı konmuş tip 2 Diabetes Mellitus'u olan bireylerde cerrahi olmayan periodontal tedaviye ek olarak C vitamini uygulamasının dişeti kanama indeksi değerlerini azalttığı ve çalışma başında düşük bulunan C vitamini düzeylerini arttırdığı gösterilmiştir. 76 Iwasaki ve ark. 'nın yaptığı çalışmada serum C ve E vitamini seviyelerinin periodontal hastalıkla ilişkisi longitudinal olarak incelenmiş; serum C ve E vitamini seviyelerinin düşük olmasının yaşlı bireylerde periodontal hastalık için risk faktörü olabileceği bildirilmiştir.…”

Section: B Karotenoi̇dlerunclassified

Antioxidant Nutrients in Periodontal Health

Gökçe¹,

Tonguç²

2018

EÜ Dişhek Fak Derg

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Periodontitis, bakterilere ve ürünlerine cevap olarak gelişen, kronik, enflamatuar bir hastalıktır ve dişi destekleyen dokularda yıkımla sonuçlanır. Oksidatif stres, reaktif oksijen ve nitrojen türleri gibi reaktif bileşiklerin üretimi ile antioksidan savunma sistemi arasındaki dengenin bozulması ile ortaya çıkar. Reaktif türler, serbest radikal zincir reaksiyonlarını başlatarak doku hasarına neden olabilir. Oksidatif stres, periodontal hastalık da dahil olmak üzere diyabet, kardiyovasküler hastalık, kanser gibi pek çok hastalığın patogenezinde rol oynamaktadır. Periodontal hastalıkta oksidatif stresin arttığı ve toplam antioksidan kapasitenin azaldığı bildirilmiştir. Antioksidanlar, canlı hücrelerde bulunan protein, lipit, karbonhidrat, DNA gibi oksitlenebilecek maddelerin oksidasyonunu engeller veya geciktirir. Sağlıklı organizmada oksidanlar ve antioksidanlar arasında bir denge mevcuttur. Antioksidan savunma organizmada doğal olarak bulunan bir mekanizma olmasına rağmen, dışarıdan alınan kaynaklar da bu savunmayı destekleyebilir. Periodontal hastalığın tedavisinde ve periodontal sağlığın korunmasında antioksidanların kullanımı son dönemde yapılan çalışmalarla önem kazanmıştır. Antioksidanlar lokal veya sistemik yollarla periodontal hastalığın tedavisinde kullanılabilir. Oksidatif stresin dengelenmesinde önemli bir role sahip olan antioksidanlara günlük hayatımızda beslenme yoluyla kolayca ulaşılabilmektedir. Bu derlemenin amacı antioksidan besinlerin periodontal sağlıktaki rolünü değerlendirmektir. Anahtar Kelimeler: oksidatif stres, antioksidan, beslenme, periodontal hastalık ABSTRACT Periodontitis is a chronic, inflammatory disease that develops in response to bacteria and their products and results in destruction in tooth supporting tissues. Oxidative stress is caused by the imbalance between the production of reactive species such as reactive oxygen and nitrogen species and the antioxidant defense system. Reactive species can cause tissue damage by initiating free radical chain reactions. Oxidative stress plays a role in the pathogenesis of many diseases including diabetes, cardiovascular disease, cancer and periodontal disease. It has been reported that oxidative stress is increased and total antioxidant capacity is decreased in periodontal disease. In a healthy organism there is a balance between oxidants and antioxidants. Although antioxidant defense is a naturally occurring mechanism in the organism, external sources may also support this defense. The use of antioxidants in the treatment of periodontal disease and periodontal health has gained importance in recent studies. Antioxidants can be used to treat periodontal disease locally or systemically. Antioxidants, which play an important role in the stabilization of oxidative stress, are easily accessible through nutrition in our daily life. The aim of this review is to evaluate the role of antioxidant nutrients in periodontal health.

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A Short-Term Evaluation of the Relationship Between Plasma Ascorbic Acid Levels and Periodontal Disease in Systemically Healthy and Type 2 Diabetes Mellitus Subjects

Abstract: Plasma AAL is below the normal range in systemically healthy subjects with gingivitis and diabetics with periodontitis. Dietary AA supplementation with SRP improves the SBI in subjects with gingivitis and diabetics with periodontitis.

Cited by 48 publications

References 31 publications

Relationship between Vitamin C and Periodontal Diseases: A Systematic Review

Relationship between Vitamin C and Periodontal Diseases: A Systematic Review

Antioxidants and Periodontal Diseases

Antioxidant Nutrients in Periodontal Health

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