A signal-on electrochemical aptasensor based on silanized cellulose nanofibers for rapid point-of-use detection of ochratoxin A

Critical review of polymer and hydrogel deposition methods for optical and electrochemical bioanalytical sensors correlated to the sensor’s applicability in real samples

“…Several analytical applications are described where doping of the polymer solution enables the immediate generation of as-use sensing nanofibers such as those made of cellulose acetate fibers doped with fluorescence probes where the high surface area afforded through the fiber structure lowered the LOD for biogenic amines by an order of magnitude in comparison to deposited films [29]. Similar findings were made for electrochemical ochratoxin detection [30]. Biocompatibility seems to be dependent on the polymer and solvents used as for other film deposition methods, and post-modification for immobilization of recognition elements can be performed likewise [31].…”

Development and clinical evaluation of commercial glucose meter coupled with nanofiber based immuno-platform for self-diagnosis of SARS-CoV-2 in saliva

“…The construction of the detection platform based on the regular polymeric casted membrane as a matrix for immobilization of the antibodies exhibited significantly lower sensitivity with LOD of 60 ng mL −1 . In contrast, the high sensitivity and performance of the diagnosis platform could be due to the robust structure of the nanofibrous membranes with the high surface area and high porosity structure, which improves the accessibility of antigens to the recognition sites [ 50 , 56 , 63 ]. In addition, the employment of the β-galactosidase as an enzymatic label has an advantage in improving the sensitivity of the diagnosis platform through the hydrolysis of lactose-generating galactose as a by-product and acts as an interference to the glucose.…”

Biopolymer-based electrospun fibers in electrochemical devices: versatile platform for energy, environment, and health monitoring

“…Further, ochratoxin A is an abundant mycotoxin teratogenic, nephrotoxic, and neurotoxic to humans and animals. Al-Dhabi et al 251 and El-Moghazy et al 252 reported innovative ultrasensitive strategies for its selective and low trace detection employing hybrids of electrospun biopolymer based EC sensors.…”