A silver-based metal–organic framework material as a ‘reservoir’ of bactericidal metal ions

Berchel, Mathieu; Gall, Tony Le; Denis, Céline; Hir, Sophie Le; Quentel, François; Elléouet, Catherine; Montier, Tristan; Rueff, Jean‐Michel; Salaün, Jean-Yves; Haelters, Jean‐Pierre; Hix, Gary B.; Lehn, Pierre; Jaffrès, Paul‐Alain

doi:10.1039/c1nj20202b

Cited by 169 publications

(121 citation statements)

References 49 publications

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“…Their rigidity provides some explaination for the production offact that they give rise to thermally stable materials 32 and in few cases non centro-symmetric materials 35 . These organic precursors, which can be synthesised at a multigram scale in 3 steps from the commercially available bromo-benzoic acid, must be also be classified in theas hetero-difunctional compounds in which both functional groups (phosphonic acid, carboxylic acid) can independently be used to connect the organic moiety to an inorganic network.…”

Section: Resultsmentioning

confidence: 99%

“…Recently we reported the first example of an efficient bactericidal silver-based hybrid in which phosphonic and carboxylate functional groups tether the organic part with the silver salt in a 3D arrangement. 32 This work was carried out within a context that aimed to study that aimed to examine the use of rigid phosphonic acid derivatives 33 , 34 as building blocks for the construction of crystalline hybrids under hydrothermal conditions to produce fluorescent, 35 thermally stable 36 and non-centrosymmetic materials. 37,38 For Through the study of the construction synthesis of silver-based hybrids we produced materials were produced with which couldthe potentially of acting as a reservoir of silver ions i.e.…”

Section: Introductionmentioning

confidence: 99%

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Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water

et al. 2015

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(Word Style "BD_Abstract").Three novel silver-based Metal Organic Frameworks materials which were synthesized from either 3-phosphono or 4-phosphonobenzoic acid and silver nitrate are reported. The novel hybrids were synthesized under hydrothermal conditions; the pH of the reaction media was controlled by adding different quantities of urea thereby producing different topologies.Compound 1 (Ag3(4-PO3-C6H4-COO)), synthesised in presence of urea, exhibits a compact 3D structure in which both phosphonic acid and carboxylic acid functional groups are linked to the silver-based inorganic network. Compound 2 (Ag(4-PO3H-C6H4-COOH)), which was synthesized at lower pH (without urea), has a layered structure in which only the phosphonic acid functional groups from 4-phosphonobenzoic acid moieties are linked to the silver inorganic network; the carboxylic acid groups being engaged in hydrogen bonds. Finally, material 3 (Ag(3-PO3H-C6H4-COOH)) was synthesised from 3-phosphonobenzoic acid and silver nitrate without urea. This material 3 features a layered structure exhibiting carboxylic acid functional groups linked via hydrogen bonds in the interlayer space. After the full characterization of these materials (single X-ray structure, IR, TGA), their ability to release silver salts in aqueous environment was measured. Silver release, determined in aqueous solution by cathodic stripping voltammetry, shows that the silver release capacity of these materials is dependent on the topology of the hybrids. The more compact structure 1 is extremely stable in water with only trace levels of silver ions being detected. On the other hand, compounds 2 and 3, in which only the phosphonic acid functional groups were bonded to the inorganic network, released larger quantities of silver ions into aqueous solution. These results which were compared with the silver release of the previously described compound 4 (Ag6(3-PO3-C6H4-COO)2). The results clearly show that the release capacity of silver-based metal organic framework can be tuned by 3 modifying their topology which, in the present study, is governed by the regio-isomer of the organic precursor and the synthetic conditions under which the hybrids are prepared.4

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water

et al. 2015

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“…Jony srebra z nośnika były uwalniane do roztworu, a następnie wykazały działanie przeciwbakteryjne przeciwko badanym szczepom Staphylococcus aureus, Escherichia coli oraz Pseudomonas aeruginosa. Przedłużone uwalnianie jonów o właści-wościach przeciwbakteryjnych otwiera perspektywy na stosowanie BioMOF-ów w preparatach o działaniu miejscowym [28].…”

Section: Mof-y Jako źRódło Metaluunclassified

“…Ponieważ barwnik Br-BODIPY jest kowalencyjnie związany z amino-BDC poprzez wiąza-nie aminowe, jego uwolnienie jest wynikiem degradacji matrycy i dowodzi również uwolnieniu cisplatyny. Badanie kontrolne barwnika niezwiązanego z nośnikiem nie wykazało fluorescencji, co tłumaczy się brakiem zdolności barwnika do przechodzenia przez błonę komórkową i wskazuje, że MIL-101(Fe) jest skutecznym nośnikiem kontrastowego środka optycznego w warunkach in vitro [8,23,28].…”

Section: Mof-y Jako Substancje Kontrastujące W Obrazowaniu Biomedycznymunclassified

Metal-Organic Frameworks: A New Class of Mesoporous Materials and Potential Possibilities of Their Use in Pharmaceutical Technology

Wyszogrodzka

Dorożyński

2016

Polim. Med.

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A -koncepcja i projekt badania; B -gromadzenie i/lub zestawianie danych; C -analiza i interpretacja danych; D -napisanie artykułu; E -krytyczne zrecenzowanie artykułu; F -zatwierdzenie ostatecznej wersji artykułu StreszczenieSieci metaloorganiczne typu MOF są nową grupą materiałów mezoporowatych o hybrydowej budowie organiczno-nieorganicznej. Ich wyjątkowe cechy: dowolność doboru elementów składowych umożliwiająca uzyskanie biozgodnych struktur oraz dobrze rozwinięta powierzchnia właściwa sprawiają, że MOF-y są obiecującymi nośnikami substancji leczniczych. MOF-y mogą być wykorzystane również w tzw. terapii celowanej, dzięki dołączonym do powierzchni nośnika ligandom lub przeciwciałom. Poprzez wbudowanie w strukturę kationów o właściwościach paramagnetycznych będzie możliwe użycie ich jako kontrastu w tomografii magnetyczno-rezonansowej (MRI). Połączenie zdolności przenoszenia cząsteczek substancji leczniczych i obrazowania w jednym nośniku wskazuje na potencjalne zastosowanie MOF-ów jako teranostyków i może dawać możliwość monitorowania substancji leczniczej w czasie rzeczywistym po wprowadzeniu do organizmu. Celem niniejszej pracy jest charakterystyka nowej grupy związków i prezentacja potencjalnych możliwości ich zastosowania jako substancji pomocniczych w technologii postaci leku (Polim. Med. 2015, 45, 2, 81-93).Słowa kluczowe: polimery koordynacyjne, układy mezoporowate, teranostyki, sieci metaloorganiczne. AbstractMetal-organic frameworks (MOFs) belong to the new class of mesoporous, hybrid materials composed of metal ions and organic binding ligands. Their unique features: wide range of chemical building components, which enables obtaining biocompatible materials, and high surface area and loading capacity, make them promising drug delivery vehicles for therapeutic agents. The ability to tune their structures and porosities provides better adjustment for adsorbed drug molecule. Moreover, MOFs functionalized with ligands or antibodies can be used in cancer targeted therapy. Through the incorporation of paramagnetic metal ions into the structure, MOFs are suited to serve as magnetic resonance imaging (MRI) contrast agents. Combining drug delivery ability with imaging properties of MOFs indicates their potential use as theranostic agents and makes possible monitoring drug delivery within the body after administration in the real time. The aim of the present study is to characterize a new class of compounds and to present potential possibilities of their use as excipients in pharmaceutical technology (Polim. Med. 2015, 45, 2, 81-93).Key words: mesoporous materials, coordination polymers, theranostics, metal-organic frameworks. Sieci metaloorganiczne (MOF -metal organic frameworks) to zupełnie nowa grupa materiałów porowatych, która pojawiła się pod koniec lat 90. XX w. Są to związki o budowie hybrydowej organiczno-nieorganicznej, określane również jako porowate sieciowe polimery koordynacyjne PCP (porous coordination polymers). Strukturę MOF stanowi sieć składająca się z dwóch głównych elementów: kationów lub...

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“…Silver ion releasing compounds are a well known family of antimicrobials and several silver containing MOF have been reported up to date to this end. Berchel et al reported a silver-based MOF with a 3-phosphonobenzoate ligand that acts as a source of silver ions and showed antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa [8]. Liu et al reported another silverbased metal-organoboron framework with antibacterial activity against Gram-negative and Gram-positive human pathogens [9].…”

Section: Introductionmentioning

confidence: 98%

Antimicrobial metal–organic frameworks incorporated into electrospun fibers

Quirós

Boltes

Aguado

et al. 2015

Chemical Engineering Journal

142

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A silver-based metal–organic framework material as a ‘reservoir’ of bactericidal metal ions

Abstract: International audienceThe silver-based MOF material Ag3(3-phosphonobenzoate) was evaluated as a bactericidal material. A sustainable release of Ag+, which was quantified by cathodic stripping voltammetry, was responsible for bactericidal activity against the 6 bacterial strains tested

Cited by 169 publications

References 49 publications

Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water

Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water

Metal-Organic Frameworks: A New Class of Mesoporous Materials and Potential Possibilities of Their Use in Pharmaceutical Technology

Antimicrobial metal–organic frameworks incorporated into electrospun fibers

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