A silyl andrographolide analogue suppresses Wnt/β-catenin signaling pathway in colon cancer

Reabroi, Somrudee; Chairoungdua, Arthit; Saeeng, Rungnapha; Kasemsuk, Teerapich; Saengsawang, Witchuda; Zhu, Weiming; Piyachaturawat, Pawinee

doi:10.1016/j.biopha.2018.02.119

Cited by 24 publications

(14 citation statements)

References 39 publications

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“…Another analogue, 3A.1 (19-tert-butyldiphenylsilyl-8, 17-epoxy andrographolide), significantly inhibited TCF/LEF promoter activity [32]. Expression levels of β-catenin and Wnt-stimulated target genes were markedly reduced.…”

Section: Wnt/β-catenin Pathwaymentioning

confidence: 99%

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The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

Farooqı

Attar

Sabitaliyevich

et al. 2020

Cancers

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There has been a paradigm shift in our understanding about the multifaceted nature of cancer and a wealth of information has revealed that single-target drugs are not good enough to provide satisfactory clinical outcomes and therapeutic effects for complex diseases which involve multiple factors. Therefore, there has been a reignition to search for natural products having premium pharmacological activities aim to efficiently target multiple deregulated cellular signaling pathways. Andrographolide, a diterpene lactone from Andrographis paniculata was brought into to the limelight because of its ability to inhibit cancer cell proliferation and induce apoptosis. Here we review andrographolide on cellular pathways regulation including Wnt/β-catenin, mTOR, VEGF-mediated intracellular signaling, as well as TRAIL-mediated apoptosis to inhibit cancer development.

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Section: Wnt/β-catenin Pathwaymentioning

confidence: 99%

“…Furthermore, analogue 3A.1 substantially enhanced function of GSK-3 β which promoted β -catenin degradation. The analogue 3A.1 mediated effect was impaired after treatment with GSK-3 β inhibitors or upon the over-expression of mutant β -catenin in colon cancer cells [ 32 ].…”

Section: Wnt/ β -Catenin Pathwaymentioning

confidence: 99%

The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

Farooqı

Attar

Sabitaliyevich

et al. 2020

Cancers

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“…[25][26][27] In this section, we summarize the andrographolide derivatives that have been identified in the past 3 years. These important derivatives include 14-tert-butyl dimethyl silicon-epoxyandrographolide; 28 3-(thiophene-2-carbonyl)−14-deoxy-11, 12 didehydroandrographolide; 29 3-dehydroandrographolide (3-DA); 30 3, 19-diacetyl-14-deoxy-11, 12-didehydroandrographolide (SRS27); 31 3-(2-methoxy-4-nitrophenyl)-andrographolie; 32 3, 14, 19-triacetyl andrographolide (CX-10); 33 AGP-26a (12β-isomer); 34 AGP-26b (12αisomer); 34 14-alpha-lipoic acylandrographolide (AL-1); 35 19-tert-butyldiphenylsilyl-8, 17-epoxy andrographolide; 36 and 19-triisopropyl andrographolide. 37 To some extent, these andrographolide derivatives address the issue of andrographolide's low oral bioavailability.…”

Section: Andrographolide and Its Derivativesmentioning

confidence: 99%

Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective

Liu

You

et al. 2021

Medicinal Research Reviews

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Andrographolide, a well-known natural lactone having a range of pharmacological actions in traditional Chinese medicine. It has long been used to cure a variety of ailments. In this review, we cover the pharmacokinetics and pharmacological activity of andrographolide which supports its further clinical application in cancers and inflammatory diseases. Growing evidence shows a good therapeutic effect in inflammatory diseases, including liver diseases, joint diseases, respiratory system diseases, nervous system diseases, heart diseases, inflammatory bowel diseases, and inflammatory skin diseases. As a result, the effects of andrographolide on immune cells and the processes that underpin them are discussed. The preclinical use of andrographolide to different organs in response to malignancies such as colorectal, liver, gastric,

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“…Apart from this, the AGP analogues successfully decreases the expression of the active form of β -catenin at the translational level and has the unique ability to function independently of GSK3 β , a negative regulator of Wnt. Interestingly, the analogues can abrogate the nuclear translocation of β -catenin by blocking the Ser675 phosphorylation, thereby causing Wnt inactivation and subsequent cancer regression ( Reabroi et al, 2018a ).…”

Section: Mode Of Action Of Andrographolide In Cancermentioning

confidence: 99%

The Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer

et al. 2021

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The conventional carcinoma treatment generally encompasses the employment of radiotherapy, chemotherapy, surgery or use of cytotoxic drugs. However, recent advances in pharmacological research have divulged the importance of traditional treatments in cancer. The aim of the present review is to provide an overview of the importance of one such medicinal herb of Chinese and Indian origin: Andrographis paniculate on colorectal cancer with special emphasis on its principal bioactive component andrographolide (AGP) and its underlying mechanisms of action. AGP has long been known to possess medicinal properties. Studies led by numerous groups of researchers shed light on its molecular mechanism of action. AGP has been shown to act in a multi-faceted manner in context of colorectal cancer by targeting matrix metalloproteinase-9, Toll-like receptor or NFκB signaling pathways. In this review, we highlighted the recent studies that show that AGP can act as an effective immunomodulator by harnessing effective anti-tumor immune response. Recent studies strongly recommend further research on this compound and its analogues, especially under in-vivo condition to assess its actual potential as a prospective and efficient candidate against colorectal cancer. The current review deals with the roles of this phytomedicine in context of colorectal cancer and briefly describes its perspectives to emerge as an essential anti-cancer drug candidate. Finally, we also point out the drawbacks and difficulties in administration of AGP and indicate the use of nano-formulations of this phytomedicine for better therapeutic efficacy.

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A silyl andrographolide analogue suppresses Wnt/β-catenin signaling pathway in colon cancer

Cited by 24 publications

References 39 publications

The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective

The Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer

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