A simple and inexpensive system for controlling body temperature in small animal experiments using MRI and the effect of body temperature on the hepatic kinetics of Gd-EOB-DTPA

Murase, Kenya; Assanai, Purapan; Takata, Hiroshige; Saito, Shigeyoshi; Nishiura, Motoko

doi:10.1016/j.mri.2013.08.005

Cited by 6 publications

(15 citation statements)

References 22 publications

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“…The body temperatures of the mice in the 39-degree, 36-degree, 33-degree, and 27-degree groups were maintained at 39, 36, 33, and 27°C, respectively, using our temperature-control system [12].…”

Section: Animal Experimentsmentioning

confidence: 99%

“…The mice in the Zym-0, Zym-25, Zym-50, and Zym-100 groups were intravenously injected with 0, 25, 50, and 100 mg/kg zymosan (Sigma-Aldrich Co., St. Louis, MO, USA), respectively, once daily for 2 days before DSC-MRI studies. The body temperature of the mice was kept at 36°C during experiments using our temperature-control system [12].…”

Section: Animal Experimentsmentioning

confidence: 99%

“…The details of our system for controlling body temperature are described in our previous paper [12]. In our temperature-control system, the rectal temperature of each mouse was monitored using an optical fiber thermometer (FL-2000, Anritsu Meter Co., Tokyo, Japan) that was immune to the radiofrequency environment, and body temperature was controlled using a feedback-regulated heated or cooled air flow generated by two Futon dryers (FD-F06A6, Panasonic Co., Osaka, Japan).…”

Section: Body Temperature Control Systemmentioning

confidence: 99%

“…When the temperature of the permanent magnet used in our MRI system is varied, the Larmor frequency of water protons may be shifted, which may result in a shift in the location of the dynamic images [12]. Therefore, before analyzing the DSC-MRI data, we corrected for this shift of the dynamic images using image registration.…”

Section: Image Registrationmentioning

confidence: 99%

“…Core body temperature gradually declines as heat is lost from the body surface, and heat production slows because of decreased metabolism [11]. Recently, we developed a simple and inexpensive system for controlling body temperature in small animal experiments using MRI and investigated the effect of body temperature on the hepatic kinetics of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) using dynamic contrast-enhanced MRI (DCE-MRI) and an empirical mathematical model (EMM) [12]. We hypothesized that the kinetic behavior of SPIONs in the liver is also affected by body temperature.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Kinetic analysis of superparamagnetic iron oxide nanoparticles in the liver of body-temperature-controlled mice using dynamic susceptibility contrast magnetic resonance imaging and an empirical mathematical model

Murase

Assanai

Takata

et al. 2015

Magnetic Resonance Imaging

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Section: Animal Experimentsmentioning

confidence: 99%

Section: Animal Experimentsmentioning

confidence: 99%

Section: Body Temperature Control Systemmentioning

confidence: 99%

Section: Image Registrationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Kinetic analysis of superparamagnetic iron oxide nanoparticles in the liver of body-temperature-controlled mice using dynamic susceptibility contrast magnetic resonance imaging and an empirical mathematical model

Murase

Assanai

Takata

et al. 2015

Magnetic Resonance Imaging

Self Cite

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Preclinical magnetic resonance imaging and spectroscopy in the fields of radiological technology, medical physics, and radiology

Saito,

Ueda

2024

Radiol Phys Technol

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Magnetic resonance imaging (MRI) is an indispensable diagnostic imaging technique used in the clinical setting. MRI is advantageous over X-ray and computed tomography (CT), because the contrast provided depends on differences in the density of various organ tissues. In addition to MRI systems in hospitals, more than 100 systems are used for research purposes in Japan in various fields, including basic scientific research, molecular and clinical investigations, and life science research, such as drug discovery, veterinary medicine, and food testing. For many years, additional preclinical imaging studies have been conducted in basic research in the fields of radiation technology, medical physics, and radiology. The preclinical MRI research includes studies using small-bore and whole-body MRI systems. In this review, we focus on the animal study using small-bore MRI systems as “preclinical MRI”. The preclinical MRI can be used to elucidate the pathophysiology of diseases and for translational research. This review will provide an overview of previous preclinical MRI studies such as brain, heart, and liver disease assessments. Also, we provide an overview of the utility of preclinical MRI studies in radiological physics and technology.

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A resistive heating system for homeothermic maintenance in small animals

Kersemans

Gilchrist

Allen

et al. 2015

Magnetic Resonance Imaging

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PurposeTo develop an MR-compatible resistive heater for temperature maintenance of anaesthetized animals.Materials and MethodsAn MR-compatible resistive electrical heater was formed from a tightly-wound twisted pair wire, interfaced to a homeothermic maintenance controller. Fat-suppressed images and localized spectra were acquired with the twisted pair heater and a near-identical single strand heater during operation at maximum power. Data were also acquired in the absence of heating to demonstrate the insensitivity of MR to distortions arising from the passage of current through the heater elements. The efficacy of temperature maintenance was examined by measuring rectal temperature immediately following induction of general anesthesia and throughout and after the acquisition of a heater artifact-prone image series.ResultsImages and spectra acquired in the presence and absence of DC current through the twisted pair heater were identical whereas the passage of current through the single strand wire created field shifts and lineshape distortions. Temperature that is lost during anesthesia induction was recovered within approximately 10–20 minutes of induction, and a stable temperature is reached as the animal's temperature approaches the set target.ConclusionThe twisted pair wire heater does not interfere with MR image quality and maintains adequate thermal input to the animal to maintain body temperature.

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A simple and inexpensive system for controlling body temperature in small animal experiments using MRI and the effect of body temperature on the hepatic kinetics of Gd-EOB-DTPA

Cited by 6 publications

References 22 publications

Kinetic analysis of superparamagnetic iron oxide nanoparticles in the liver of body-temperature-controlled mice using dynamic susceptibility contrast magnetic resonance imaging and an empirical mathematical model

Kinetic analysis of superparamagnetic iron oxide nanoparticles in the liver of body-temperature-controlled mice using dynamic susceptibility contrast magnetic resonance imaging and an empirical mathematical model

Preclinical magnetic resonance imaging and spectroscopy in the fields of radiological technology, medical physics, and radiology

A resistive heating system for homeothermic maintenance in small animals

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