A Simple and Sensitive Method for Auramine O Detection Based on the Binding Interaction with Bovin Serum Albumin

Yan, Jingjing; Huang, Xin; Liu, Shaopu; Yang, Jinlong; Yuan, Yusheng; Duan, Ruilin; Zhang, Hui; Hu, Xiaoli

doi:10.2116/analsci.32.819

Cited by 10 publications

(2 citation statements)

References 39 publications

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“…Therefore, AuO is forbidden in food matrices by many international food regulation acts, including European Union, China, Japan, and the United States . Meanwhile, many sensitive and rapid methods are developed for the detection and removal of AuO to ensure a safe living environment . However, whether AuO damages the respiratory system remains fully unknown.…”

Section: Discussionmentioning

confidence: 99%

Auramine O, an incense smoke ingredient, promotes lung cancer malignancy

Tung

Huang

Yang

et al. 2017

Environmental Toxicology

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Burning incense to worship deities is a popular religious ritual in large parts of Asia, and is a popular custom affecting more than 1.5 billion adherents. Due to incomplete combustion, burning incense has been well recognized to generate airborne hazards to human health. However, the correlation between burning incense and lung cancer in epidemiological studies remains controversy. Therefore, we speculated that some unknown materials in incense smoke are involved in the initiation or progression of lung cancer. Based on this hypothesis, we identified a major compound auramine O (AuO) from the water‐soluble fraction of incense burned condensate using mass spectrometry. AuO is commonly used in incense manufacture as a colorant. Due to thermostable, AuO released from burned incenses becomes an unexpected air pollutant. AuO is classified as a Group 2B chemical by the International Agency of Research on Cancer (IARC), however, the damage of AuO to the respiratory system remains elusive. Our study revealed that AuO has no apparent effect on malignant transformation; but, it dramatically promotes lung cancer malignancy. AuO accumulates in the nucleus and induces the autophagy activity in lung tumor cells. AuO significantly enhances migration and invasive abilities and the in vitro and in vivo stemness features of lung tumor cells through activating the expression of aldehyde dehydrogenase family 1 member A1 (ALDH1A1), and ALDH1A1 knockdown attenuates AuO‐induced autophagy activity and blocks AuO‐induced lung tumor malignancy. In conclusion, we found that AuO, an ingredient of incense smoke, significantly increases the metastatic abilities and stemness characters of lung tumor cells through the activation of ALDH1A1, which is known to be associated with poor outcome and progression of lung cancer. For public health, reducing or avoiding the use of AuO in incense is recommended.

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Section: Discussionmentioning

confidence: 99%

Auramine O, an incense smoke ingredient, promotes lung cancer malignancy

Tung

Huang

Yang

et al. 2017

Environmental Toxicology

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“…AO hydrochloride is widely used in the chemical industry for coloring material in paper, textiles, and leather industries . Related research indicated that it could irritate skin, cause conjunctivitis, dermatitis, and upper respiratory irritation symptoms after consumption . International Agency for Research on Cancer (IARC) provided sufficient evidence for the carcinogenicity of AO to humans and animals .…”

Section: Introductionmentioning

confidence: 99%

Preparation of stoichiometric molecularly imprinted polymer coatings on magnetic particles for the selective extraction of auramine O from water

Yang

Muhammad

Yigaimu

et al. 2018

J of Separation Science

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A novel magnetic molecularly imprinted polymer for the selective recognition of auramine O was rationally designed via screening from a library of nonimprinted polymers. A stoichiometric ratio of functional monomer (itaconic acid) and template molecule (auramine O) was found to be 1.5. Meanwhile, the synthesized SiO @Fe O was modified by 0.5 mol/L hydrochloric acid to facilitate the preparation of magnetic molecularly imprinted polymer particles. Adsorption experiments showed that the magnetic polymer particles exhibited good selectivity, recoveries, and enrichment performance. The stoichiometric imprinted polymers have been employed for the selective preconcentration of auramine O from lake water sample. The high specificity of the stoichiometric imprinted polymers was proven in the extraction of mixture solution of auramine O, auramine O hydrochloride, and chrysoidine, and the recoveries ranged between 99.66 and 108.75% (RSD 2.6-3.7%, n = 3) for lake water. These results suggest that this method is effective and can be successfully applied to the analysis of auramine O in environmental water samples.

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