A Simple and Specific HPLC Method for the Determination of Atomoxetine in Pharmaceuticals and Human Plasma

Doğrukol-Ak, Dilek; Yeniceli, Duygu

doi:10.1080/10826076.2010.526816

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…The proposed method was validated and the LOD was found to be 0.24 ng/mL [92]. Other HPLC methods for the quantification of AMP, MPH, ATX, and BUP in human biological samples [93][94][95][96][97][98][99][100][101][102][103][104][105][106][107][108] and their chromatographic conditions are reported in Table 1.…”

Section: Liquid Chromatography (Lc)mentioning

confidence: 99%

Review on analytical methods for quantification of ADHD drugs in human biological samples

Sundari¹,

Amuthalakshmi²,

Nalini³

2020

Reviews in Analytical Chemistry

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Attention deficit hyperactivity disorder (ADHD) is a common neuro-developmental disorder. The symptoms of ADHD include difficulty in attention, memory and impulse control. Many pharmaceutical formulations (stimulants and non-stimulants) are available on the market to treat ADHD symptoms. The most commonly used drugs for treatment are amphetamine, methylphenidate, atomoxetine, bupropion, guanfacine and clonidine. In the field of pharmaceuticals, bioanalysis is an important tool used for the quantification of drugs and their metabolites present in biological samples using various analytical methods. Although a number of analytical methods were reported for the quantification of these drugs in biological samples of experimental animals, due to species differences, it is important to develop analytical methods to quantify these drugs in human biological samples to aid forensic and pharmacokinetic studies. In this review, we compile the bio-analytical methods such as spectrophotometry, spectrofluorimetry, mass spectrometry, electrophoresis, liquid chromatography and gas chromatography used for the quantification of ADHD drugs in human biological samples such as blood, plasma, serum, oral fluids, sweat, hair and urine based on earlier published articles from various journals.

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Section: Liquid Chromatography (Lc)mentioning

confidence: 99%

Review on analytical methods for quantification of ADHD drugs in human biological samples

Sundari¹,

Amuthalakshmi²,

Nalini³

2020

Reviews in Analytical Chemistry

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“…The most prevalent neurobehavioral condition of childhood is ADHD, and some individuals’ symptoms last into adulthood. It is characterised by signs of impulsivity, hyperactivity, and inattentiveness that interfere with academic and social performance [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

A novel spectrophotometric approach relies on a charge transfer complex between atomoxetine with quinone-based π-acceptor. Application to content uniformity test

Abu‐hassan

2023

BMC Chemistry

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Atomoxetine (ATO) belongs to psychoanaleptic drugs and is utilized in attention-deficit hyperactivity syndrome treatment. In this study, two facile and selective approaches are implemented for the spectrophotometric analysis of atomoxetine. The two approaches rely on charge transfer formed between ATO base (n-donor) with p-chloranil and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ; π-acceptor). The generated complexes exhibit absorption intensity maxima at 550 and 460 nm in acetonitrile for p-chloranil and DDQ in the order. Under the optimum reaction condition, Beer’s law was followed for p-chloranil and DDQ at concentrations of 30–320 and 10–80 µg mL− 1, respectively. The ICH guidelines were followed for work validation, and the outcomes were excellent and satisfactory. The assessment of ATO in pharmaceutical capsules using the suggested procedures was successful, and the results were contrasted with those obtained using a different published method to show accuracy and precision. Additionally, the two methods were used to assess the homogeneity of ATO content in the commercialized capsule.

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UPLC versus HPLC on Drug Analysis: Advantageous, Applications and Their Validation Parameters

2013

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A Simple and Specific HPLC Method for the Determination of Atomoxetine in Pharmaceuticals and Human Plasma

Cited by 6 publications

References 12 publications

Review on analytical methods for quantification of ADHD drugs in human biological samples

Review on analytical methods for quantification of ADHD drugs in human biological samples

A novel spectrophotometric approach relies on a charge transfer complex between atomoxetine with quinone-based π-acceptor. Application to content uniformity test

UPLC versus HPLC on Drug Analysis: Advantageous, Applications and Their Validation Parameters

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