A simple dietary addition of fenugreek seed leads to the reduction in blood glucose levels: A parallel group, randomized single-blind trial

Ranade, Manjiri; Mudgalkar, Nikhil

doi:10.4103/ayu.ayu_209_15

Cited by 34 publications

(25 citation statements)

References 12 publications

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“…31 Another clinical trial proved that fenugreek seeds water significantly reduced FBS and HbA 1 c within 6 months. 32 A 10 days RCT of stress induced hyperglycemia (SIH) in critically ill patient used 3 gm of fenugreek seeds powder by gavage twice a day along with routine medication found significant reduction in mean blood glucose levels and good prognosis observed than the control group with routine medication. 33 Another 3 month RCT found a significant reduction in FBS and lipid profile after intake of 2 gm fenugreek (capsule form three times per day along with metformin) than 5 gm glibenclamide (once a day along with metformin) among uncontrolled type 2 DM.…”

Section: Discussionmentioning

confidence: 99%

Comparing the effect of ladies’ finger water with fenugreek seeds water on the blood glucose level among subjects with type 2 diabetes mellitus-a randomized controlled trial

et al. 2021

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Background: The primary aim of managing diabetes is to maintain blood glucose level to prevent diabetes induced complications. Studies showed that ladies finger and fenugreek seeds are blood sugar stabilizer. The objective of this randomized active controlled trial was to assess the effect of ladies finger water versus fenugreek seeds water on the blood glucose level among subject with type 2 diabetes.Methods: Total of 180 study participants were selected and equally assigned to three groups by computer generated randomization. Group 1-received ladies finger water and oral antidiabetic drug (OAD); group 2-received fenugreek seeds water and OAD; group 3-received only OAD for 15 days. Pre and post intervention fasting blood sugar (FBS) was assessed by accu-chek Performa glucometer. Wilcoxon signed rank test; one-way analysis of covariance followed by post hoc test with Bon-ferroni correction was done.Results: Analysis was done based on 168 subjects. There was a significant reduction in FBS level with the mean difference of group 1-21.0 mg/dl (p<0.001), group 2-20.3 mg/dl (p<0.001) and group 3-4.7 mg/dl (p=0.068). No significant difference found between group 1 and group 2 (p=1.00), but significant difference found between group 1 and group 3 (p=0.032); group 2 and group 3 (p=0.012). Both ladies finger water and fenugreek seeds water were superior in reduction of FBS than OAD.Conclusions: Ladies finger water or fenugreek seeds water can be used as adjunct along with OAD to control type 2 diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Comparing the effect of ladies’ finger water with fenugreek seeds water on the blood glucose level among subjects with type 2 diabetes mellitus-a randomized controlled trial

et al. 2021

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“…Fenugreek seeds have a synergistic effect on diet control exercise and fasting blood glucose and HbA1c [40].…”

Section: Anti-inflammatory and Anti-arthritic Activity Of Fenugreek Seedsmentioning

confidence: 99%

Edible Seeds Medicinal Value, Therapeutic Applications and Functional Properties-a Review

Chandrasekar¹,

Sivagami²

2021

Int J Pharm Pharm Sci

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India has a rich source of tropical fruits containing edible seeds such as chia, hemp, sesame, pumkin, sunflower, mustard, nigella, guava, papaya, mangosteen, honeydew, pomegranate, fennel, fenugreek, cumin, sweet orange, cucumber, jackfruit, mango, melons, avocado and many more. These products such as the seed kernel, which constitutes about 10–35% of the weight, offer high nutritional value and therapeutic applications. This article explores the nutritional, medicinal, therapeutic applications, functional properties and bioactive constituents of the seeds of some fruits, which are analyzed for their functions and applications as sources of food value and bioactive phytochemical constituents. The seeds contain essential bioactive components such as alkaloids, carotenoids, flavonoids, glycosides, saponins, terpenoids, tannins, steroids and polyphenolic compounds and that exhibit excellent anti-inflammatory, antioxidant properties, anticancer, anti-diabetic, anti-hyperlipidemic, anti-obesity, neurological disorders, cardiovascular, skin diseases and chronic diseases. They have remarkable physicochemical properties and a high content of carbohydrates, fats, proteins, vitamins, and minerals. However extensive research activities can be carried out to determine the efficacy of the nutritional and bioactive components in different seed types, the bioavailability and potency. Extensive research with the seed parts can be investigated to identify the medicinal and functional potentials of these fruit seeds. This review gives an overview on the therapeutic applications and functional properties of seeds present in fruits, vegetables and medicinal plants. The medicinal and nutritional value, phytochemical composition, bioactive phytoconstituents, therapeutic activity, therapeutic applications and uses, proximate analysis, functional properties, analytical methods, spectroscopic methods and human clinical trials of some edible seeds are discussed in this review.

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“…An independent meta-analysis of 12 randomized clinical trials reported that fenugreek significantly decreased the levels of fasting blood glucose, 2-h postprandial blood glucose, hemoglobin A1c, and total cholesterol (Gong et al, 2016). Furthermore, several other studies have shown the promising effects of fenugreek in lowering hemoglobin A1c levels (Ranade & Mudgalkar, 2017;Suchitra & Parthasarathy, 2015) and improving insulin sensitivity (Kiss et al, 2018;Sharma & Raghuram, 1990;Suchitra & Parthasarathy, 2015). In a study with 114 T2DM patients (Geberemeskel, Debebe, & Nguse, 2019), a fenugreek powder solution, orally consumed for 30 consecutive days, was able to significantly improve the lipid profile of these patients compared with a placebo control.…”

Section: Crop Sciencementioning

confidence: 99%

Canadian sainfoin and fenugreek as forage and functional foods

et al. 2020

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Sainfoin (Onobrychis viciifolia Scop.) and fenugreek (Trigonella foenum‐graecum L.) are two legumes that are being developed as forage crops in Canada with potential benefits for animal and human health. Sainfoin, a perennial crop containing condensed tannins (CTs), is gaining popularity in western Canada because of its benefits for cattle. Its CTs make the crop bloat‐free for grazing cattle while improving protein digestibility and reducing greenhouse gas emissions. The CT‐containing fenugreek is also considered as a bloat‐free annual forage legume that was developed to serve in short‐term crop rotations in western Canada. These crops are known to provide health and nutritional benefits to cattle with their high protein content and other beneficial nutraceuticals such as crude fiber, 4‐hydroxyisoleucine, steroid sapogenins, and galactomannans. Some of these nutraceuticals have the potential to benefit human health; however, such attributes have not been studied enough to harness the full potential of these legume crops in Canada. Recent research suggests that legumes are a healthy substitute for meat. However, metabolite analysis of sainfoin is mostly limited to proteins and CTs. The CTs reported in sainfoin are involved in reduction of blood pressure and detoxification and providing anticancer properties in humans. Recent studies on fenugreek have highlighted the beneficial nutraceuticals associated with human health but most of those claims are not backed by relevant clinical studies. In this article, we reviewed the nutritional quality attributes of sainfoin and fenugreek and assessed their potential as functional foods and nutraceuticals for animal and human health based on scientific evidence.

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A simple dietary addition of fenugreek seed leads to the reduction in blood glucose levels: A parallel group, randomized single-blind trial

Cited by 34 publications

References 12 publications

Comparing the effect of ladies’ finger water with fenugreek seeds water on the blood glucose level among subjects with type 2 diabetes mellitus-a randomized controlled trial

Comparing the effect of ladies’ finger water with fenugreek seeds water on the blood glucose level among subjects with type 2 diabetes mellitus-a randomized controlled trial

Edible Seeds Medicinal Value, Therapeutic Applications and Functional Properties-a Review

Canadian sainfoin and fenugreek as forage and functional foods

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