A simple method for production of trackless focal lesions with focused ultrasound: physical factors

Lele, P. P.

doi:10.1113/jphysiol.1962.sp006862

Cited by 128 publications

(51 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The concept was developed 41 years ago (1), but its widespread use in the clinical setting required a system for accurate guidance and monitoring. With the advent of magnetic resonance imaging (MRI), FUS as a treatment modality has experienced a rebirth, with growing interest for its use in a number of clinical applications.…”

Section: High-intensity Focused Ultrasound (Fus)mentioning

confidence: 99%

Prediction of subtle thermal histopathological change using a novel analysis of Gd‐DTPA kinetics

Cheng

Purcell

Bilbao

et al. 2003

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To investigate Gd-DTPA kinetics as predictors of histopathological changes following focused ultrasound (FUS) thermal ablation for improved planning and assessment. Materials and Methods:Twenty-nine FUS lesions were created in the thigh muscle of eight rabbits under MRguidance at 1.5 Tesla. Three rabbits were killed at four hours; and 11 lesions were analyzed with histopathology. Temperature-sensitive MRI using proton-resonant frequency-shift was used for time-dependent temperature measurements. Analysis of the uptake kinetics of Gd-DTPA was performed after Gd-DTPA injection, within 20 minutes after heating and again at two hours after heating. The resulting kinetic maps, permeability (K trans ) and leakage space (v e ), were correlated to peak temperatures, T 2 -weighted MR, and histopathology.Results: Images of K trans and v e reveal regions of histopathological change not visible on conventional posttherapy MR. At early times after heating, v e predicts the area of injury more accurately than T 2 (7 Ϯ 2% vs. 25 Ϯ 6% underestimation). A circular region of extensive structural/ vascular disruption is indicated only on K trans maps. The sharp decrease in K trans at the boundary of this region occurs at 47.5 Ϯ 0.5°C, and may be a better estimate of cell death than the conventional method of temperature threshold (55°C for coagulation) used in therapy planning. Conclusion:Our results suggest Gd-DTPA kinetics can predict different histopathological changes following FUS ablation and may be valuable for early prediction.

show abstract

Section: High-intensity Focused Ultrasound (Fus)mentioning

confidence: 99%

Prediction of subtle thermal histopathological change using a novel analysis of Gd‐DTPA kinetics

Cheng

Purcell

Bilbao

et al. 2003

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Most notably, Lele conducted a large number of experiments, many with implanted micro-thermocouples. Lele's work established that the ultrasound-induced tissue damage was caused by temperature elevation in the focus [10,11]. He continued these animal studies related to ultrasound surgery of the brain for more than a decade, with only a few publications but a wealth of information hidden in student dissertations and summarized in conference papers.…”

Section: Early Researchmentioning

confidence: 97%

Clinical applications of focused ultrasound—The brain

Hynynen

Clement

2007

International Journal of Hyperthermia

121

View full text Add to dashboard Cite

show abstract

“…hermal ablation of brain in animals with high intensity focused ultrasound (HIFU) was very popular in the 50's and 60's [1][2]. HIFU was used in the clinical setting by Fry and Johnson [3] and showed that HIFU had the potential to treat brain cancer.…”

Section: Introductionmentioning

confidence: 99%

Penetration of high intensity focused ultrasound ex vivo and in vivo rabbit brain using MR imaging

Hadjisavvas

Damianou

Ioannides

et al. 2009

2009 9th International Conference on Information Technology and Applications in Biomedicine

View full text Add to dashboard Cite

Abstract-In this paper magnetic resonance imaging (MRI) is investigated for monitoring the penetration of high intensity focused ultrasound (HIFU) in vitro and in vivo rabbit brain. A single element spherically focused transducer of 5 cm diameter, focusing at 10 cm and operating at 2 MHz was used. A prototype MRI-compatible positioning device is described. MRI images were taken using fast spin echo (FSE). The length of the lesions in vivo rabbit brain was much higher than the length in vitro, proving that the penetration in the in vitro brain is limited by reflection due to trapped bubbles in the blood vessels.

show abstract

A simple method for production of trackless focal lesions with focused ultrasound: physical factors

Cited by 128 publications

References 11 publications

Prediction of subtle thermal histopathological change using a novel analysis of Gd‐DTPA kinetics

Prediction of subtle thermal histopathological change using a novel analysis of Gd‐DTPA kinetics

Clinical applications of focused ultrasound—The brain

Penetration of high intensity focused ultrasound ex vivo and in vivo rabbit brain using MR imaging

Contact Info

Product

Resources

About