A simple microfluidic tool to design anisotropic microgels

Keller, Shauni; Dekkers, René; Hu, Guo Xun; Tollemeto, Matteo; Morosini, Martina; Keskin, Arif; Wilson, Daniela A.

doi:10.1016/j.reactfunctpolym.2021.105012

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/foods12183385/s1, Table S1: Commercial microfluidic devices used to generate emulsion droplets; Table S2: Technological approaches and properties of the delivery systems based on food-grade emulsions assembled by microfluidic techniques; Table S3: Trends in droplet-based microfluidics approaches for fabricating delivery systems based on emulsions. References [115,116,[123][124][125][126][127][128][129][130][131][132][133][134][135] are cited in Supplementary Materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

Droplet-Based Microfluidics as a Platform to Design Food-Grade Delivery Systems Based on the Entrapped Compound Type

Bianchi,

de la Torre,

Costa

2023

Foods

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Microfluidic technology has emerged as a powerful tool for several applications, including chemistry, physics, biology, and engineering. Due to the laminar regime, droplet-based microfluidics enable the development of diverse delivery systems based on food-grade emulsions, such as multiple emulsions, microgels, microcapsules, solid lipid microparticles, and giant liposomes. Additionally, by precisely manipulating fluids on the low-energy-demand micrometer scale, it becomes possible to control the size, shape, and dispersity of generated droplets, which makes microfluidic emulsification an excellent approach for tailoring delivery system properties based on the nature of the entrapped compounds. Thus, this review points out the most current advances in droplet-based microfluidic processes, which successfully use food-grade emulsions to develop simple and complex delivery systems. In this context, we summarized the principles of droplet-based microfluidics, introducing the most common microdevice geometries, the materials used in the manufacture, and the forces involved in the different droplet-generation processes into the microchannels. Subsequently, the encapsulated compound type, classified as lipophilic or hydrophilic functional compounds, was used as a starting point to present current advances in delivery systems using food-grade emulsions and their assembly using microfluidic technologies. Finally, we discuss the limitations and perspectives of scale-up in droplet-based microfluidic approaches, including the challenges that have limited the transition of microfluidic processes from the lab-scale to the industrial-scale.

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