Influential research has stressed the importance of uncertainty for controlling the speed of learning, and of volatility (the inferred rate of change) in this process. This framework recasts biological learning as a problem of statistical inference, to produce prominent computational models that have extensive correlates in brain and behavior and burgeoning applications to psychopathology. Here, we investigate a neglected feature of these models, which is that learning rates are jointly determined by the comparison between volatility and a second factor, unpredictability (reflecting moment-to-moment stochasticity rather than systematic change). For the organism, volatility and unpredictability both manifest as noisy experiences, but for learning, they should have opposite effects: learning should speed up as volatility increases but slow down as unpredictability increases. Like volatility, unpredictability can vary and must be estimated by the learner. Previous work has focused on half this picture, studying how organisms estimate volatility while unpredictability is assumed fixed and known. The question how the brain estimates unpredictability (and ultimately, a full account of volatility, uncertainty and learning rates, which all depend on it) remains unaddressed. We introduce a new learning model, in which both unpredictability and volatility are learned from experience. We show evidence from the behavioral and decision neuroscience literatures that the brain distinguishes these two similar types of noise, so as to produce seemingly contradictory behavior in different situations. Further, the model highlights the extent to which inferences about volatility and unpredictability are interdependent, such that disruptions of computations related to volatility can impact computations related to unpredictability, and vice versa. We argue that this interdependence is apparent in learning following amygdala damage, and may have important implications for ongoing attempts to connect volatility and uncertainty to psychopathology.