A simple non-aqueous method for carboxymethylation of galactomannans

Oxidation of β-glucan extracted from Poria Cocos and its physiological activities

“…The increased solubility as a result of oxidation has been observed in the literature (Tamura et al, 2009). Binding of bile acids and subsequent excretion in feces have been recognized as a significant mechanism to eliminate excess cholesterol because bile acids are steroid carboxylic acids synthesized in liver from cholesterol (Yang & Du, 2003;Zhang, Zhang & Cheung, 2003;Parvathy, Susheelamma, Tharanathan & Gaonkar, 2005). Therefore, high binding capacity of bile acids suggests a possible ability to lower cholesterol in the body.…”

Tailoring of locust bean gum and development of hydrogel beads for controlled oral delivery of glipizide

“…Figure 1 represents the FTIR spectrum of LBG and CMLBG. A broad, very strong O-H stretching of hydroxyl group was identified in both LBG and CMLBG at 3433.86 cm −1 and 3462.00 cm −1 , respectively (Parvathy et al, 2005). The vibrations related to -CH2 bending/wagging was detected in the spectrum of both LBG and CMLBG at frequencies of 2926.96 cm −1 and 2957.54 cm −1 , respectively.…”

“…The band at ∼ 1000-1100 cm −1 was mainly attributed to C-O-H stretching/bending, and was also identified in the derivative without marked changes. The presence of carboxymethylated groups in CMLBG was demonstrated at 909.82 cm −1 , representing symmetric C-O-C stretching (Parvathy et al, 2005). In CMLBG, -CH2 stretching vibration was also increased (1325.13 cm −1 ) compared to LBG (1306.87 cm −1 ).…”

“…In the present investigation, locust bean gum was chemically modified to alter its physicochemical properties, e.g. primary structures, hydrophilicity, polyelectrolytic nature, solution rheology, and gel forming behavior, such that specific functional properties can be improved (Sierakowaski et al, 2000;Parvathy et al, 2005). Carboxymethylation is a well established chemical treatment of polysaccharides to convert the hydroxyl groups into carboxymethylate.…”

Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery

“…Natural polymers such as inulin [34], cashew gum [35], xyloglucan gum [36] locust bean gum [37], starch [38], hemicelluloses [39], konjac glucomannan [40], xylan [41], guar gum and tara gum [42] have been carboxymethylated. Carboxymethylation can be undertaken by aqueous and non-aqueous methods [36,42]. Carboxymethylation of plant polymer is a process shown in Figure 3.…”