Tailoring of locust bean gum and development of hydrogel beads for controlled oral delivery of glipizide

Maiti, Sabyasachi; Dey, Paramita; Banik, Arunava; Sa, Biswanath; Ray, Somasree; Kaity, Santanu

doi:10.3109/10717541003706265

Cited by 62 publications

(29 citation statements)

References 56 publications

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“…Maiti et al composed beads of a carboxymethyl derivative of LBG and loaded them with Glipizide, a drug that is used for the treatment of type 2 diabetes [9]. The drug was loaded efficiently into the beads at a range of 93.35%–94.80% and found to be quite stable.…”

Section: Lbg As Carrier Agent For Controlled Release Of Drugsmentioning

confidence: 99%

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Functional Components of Carob Fruit: Linking the Chemical and Biological Space

Goulas

Stylos

Chatziathanasiadou

et al. 2016

IJMS

130

135

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The contribution of natural products to the drug-discovery pipeline has been remarkable since they have served as a rich source for drug development and discovery. Natural products have adapted, during the course of evolution, optimum chemical scaffolds against a wide variety of diseases, including cancer and diabetes. Advances in high-throughput screening assays, assisted by the continuous development on the instrumentation’s capabilities and omics, have resulted in charting a large chemical and biological space of drug-like compounds, originating from natural sources. Herein, we attempt to integrate the information on the chemical composition and the associated biological impact of carob fruit in regards to human health. The beneficial and health-promoting effects of carob along with the clinical trials and the drug formulations derived from carob’s natural components are presented in this review.

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Section: Lbg As Carrier Agent For Controlled Release Of Drugsmentioning

confidence: 99%

“…In addition to the food industry, LBG is widely used for pharmaceutical purposes as it is linked with the inhibition of gastrointestinal diseases [5,6,7,8]. Furthermore, LBG is exploited as a carrier agent for the controlled release of drugs alone or in combination with other carrier molecules [9,10,11,12,13,14,15,16]. …”

Section: Introductionmentioning

confidence: 99%

Functional Components of Carob Fruit: Linking the Chemical and Biological Space

Goulas

Stylos

Chatziathanasiadou

et al. 2016

IJMS

130

135

View full text Add to dashboard Cite

show abstract

“…LBG has been successfully employed in the preparation of various controlled-release delivery systems like tablets, beads, microspheres, etc. (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

A Novel Synergistic Galactomannan-Based Unit Dosage Form for Sustained Release of Acarbose

Kumar

Sinha

2012

AAPS PharmSciTech

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Abstract. In the current study, the potential of a novel combination of a galactomannan with acarbose (100 mg) was evaluated for attaining a desired hypoglycaemic effect over a prolonged period of time. Three major antidiabetic galactomannans viz., fenugreek gum, boswellia gum, and locust bean gum were selected in order to achieve a synergistic effect in the treatment alongwith retardation in drug release. In vitro studies indicated that batches containing various proportions of fenugreek gum (AF40-60) were able to control drug release for a longer duration of approximately 10-12 h. In contrast, the matrices prepared using boswellia and locust bean gum were able to sustain the release for relatively shorter durations. Drug release mainly followed first-order release kinetics owing to the highly soluble nature of the drug. In vivo study depicted a significant reduction (p<0.001) in the postprandial blood glucose and triglyceride levels in the diabetic rats on treatment with formulation AF40. Thus, the developed system provides a better control of the postprandial glycaemic levels and it also obviates the need of conventional multiple dosing of acarbose. Furthermore, it also reduces the occurrence of side effects like diarrhea and loss of appetite.

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“…It is widely used in the food industry as stabilizer and viscosity modifier, as well as in the textile industry by its film-forming properties [4] . It has found increasing applications in the drug delivery systems and tissue engineering purpose [5][6][7] . Although, LBG has wide range of uses and applications, it suffers from certain drawback like uncontrolled hydration, microbial contamination and drop in viscosity.…”

Section: Introductionmentioning

confidence: 99%