A simple spectrophotometric method for the determination of captopril in pharmaceutical preparations using ammonium molybdate

Abstract

A simple, rapid and sensitive spectrophotometric method for the determination of captopril (CPT) in pharmaceutical formulations is proposed. This method is based on the reduction reaction of ammonium molybdate, in the presence of sulphuric acid, for the group thiol of CPT, producing a green compound (λ max 407 nm). Beer's law is obeyed in a concentration range of 4.60 x 10 -4 -1.84 x 10 -3 mol l -1 of CPT with an excellent correlation coefficient (r = 0.9995). The limit of detection and limit of quantification were 7.31 x 10 -6 e 2.43 x 10 -5 mol l -1 of CPT, respectively. The proposed method was successfully applied to the determination of CPT in commercial brands of pharmaceuticals. No interferences were observed from the common excipients in the formulations. The results obtained by the proposed method were favorably compared with those given by the official reported method at 95 % confidence level.

Spectrophotometric Indirect Determination of Captopril through Redox Reaction with n-bromosuccinimide and RB dye in Pharmaceutical Products

“…These preferences boosted the application of the proposed method in routine quality control of captopril in industrial laboratories. Ribeiro, et al, 2010 4.60×10 -4 -1.84×10 -3 7.31×10 -6…”

A Novel Use of 3-Methyl-2-Benzothiazolinone Hydrazone Hydrochloride Monohydrate for Kinetic Spectrophotometric Determination of Captopril in Pharmaceutical Formulations

“…3). Among the various oxidants NaIO 4 , K 2 Cr 2 O 7 , Ce(SO 4 ) 2 , FeCl 3 and KIO 4 were examined in combination with MBTH for oxidative coupling reaction. Ce (IV) and Fe (III) were responded for color development with MBTH.…”

“…About 30% of the drug is bound to plasma protein [2][3]. In order to assure the quality of CPT containing pharmaceutical formulations, several analytical methods have been reported for its determination, including spectrophotometric [4][5][6][7][8][9], kinetic spectrophotometric methods [10][11][12][13], high performance liquid chromatography (HPLC) [14][15][16], polarography [17], stripping voltammetry [18][19], fluorimetry [20], atomic absorption spectrophotometry [21], flow injection analysis [22][23][24][25],and potentiometry [26].…”

Simultaneous estimation of captopril and hydrochlorothiazide in combined dosage forms

“…It is the prototype of the thiazide group and antihypertensive drug. [3] Literature survey reveals that CAP was determined by several methods including spectrophotometric, [4][5][6][7][8] HPLC, [9][10][11] flow injection biamperometric, [12] flow injection chemiluminescence, [13] potentiometric and visual titrimetric, [14] and FT-Raman spectroscopy. [15] HZ was determined by capillary electrophoresis, [16] electrochemical study, [17] spectrophotometric, [18][19][20][21][22] and HPLC.…”