A simplified model for equilibrium and transient swelling of thermo-responsive gels

Drozdov, Aleksey D.; Christiansen, Jesper de Claville

doi:10.1016/j.jmbbm.2017.06.034

Cited by 12 publications

(11 citation statements)

References 51 publications

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“…This dependence is sometimes utilized in application, in other cases, it is rather a complicating factor. Extensive literature exists on the effect of deformation on swelling of gels including those showing VPT [ 36 , 54 , 55 , 56 , 57 , 58 ]. Sometimes, this dependence can serve to make the transition observable for systems that do not show the transition at free swelling.…”

Section: The Elastic Contribution and Swelling Change Of The Chemimentioning

confidence: 99%

Volume Phase Transition in Gels: Its Discovery and Development

Dušek

Dušková‐Smrčková

2020

Gels

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The history of volume phase transition of responsive gels from its theoretical prediction to experimental discovery was described and the major role of mixing Gibbs energy function in theoretical models was stressed. For detailed analysis and fine tuning of the volume phase transition, the generalized Flory–Huggins model with concentration and temperature dependent interaction function coupled with Maxwell construction as a tool is very suitable. Application of expansive stresses can uncover the potential of various swelling gels for volume phase transition. Experimentally, the abrupt, equilibrium-controlled phase transition is often hard to achieve due to passage of gel through states of mechanical instability and slow relaxation processes in macroscopic objects.

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Section: The Elastic Contribution and Swelling Change Of The Chemimentioning

confidence: 99%

Volume Phase Transition in Gels: Its Discovery and Development

Dušek

Dušková‐Smrčková

2020

Gels

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“…Several crosslinking organic compounds are used to increase crosslinking densities and accelerate crosslinking processes. 20–24…”

Section: Introductionmentioning

confidence: 99%

“…Several crosslinking organic compounds are used to increase crosslinking densities and accelerate crosslinking processes. [20][21][22][23][24] Temperature-sensitive hydrogels are one of the important types in stimuli-responsive gels whose degree of swelling is strongly affected by temperature. If temperature-sensitive hydrogels submerge in water or any solution below critical temperature (T c ), they swell noticeably due to water penetration from the surrounding environment.…”

Section: Introductionmentioning

confidence: 99%

Mechanical and microstructural characterization of poly(N-isopropylacrylamide) hydrogels and its nanocomposites

Düşünceli

Sanporean

Drozdov

et al. 2021

Proceedings of the Institution of Mechanical Engineers, Part L:

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Mechanical behavior dependency of the poly(N-isopropylacrylamide) hydrogel related to the amount of initiator, crosslinker, and nanoparticles was investigated. An experimental approach has been undertaken to observe these dependencies and assess the amount of initiator (ammonium persulfate), crosslinker (N, N′-methylene-bisacrylamide), and nanoparticles (graphene oxide) on the macroscopic responses of poly(N-isopropylacrylamide). Different amounts of initiator, crosslinker, and nanoparticle were used to manufacture specimens for the compression test. The specimens were subjected to compressive loading up to breakage to investigate the breaking behavior of poly(N-isopropylacrylamide). The responses of these specimens indicated that the mechanical behavior of poly(N-isopropylacrylamide) was highly nonlinear and depends on these ingredients. The mechanical responses of poly(N-isopropylacrylamide) were simulated using the ideal network model. The simulation results of the mathematical model substantially complied with the experimental data of poly(N-isopropylacrylamide). In addition, a more in-depth microstructural analysis was performed on these specimens. The analysis results allowed us to correlate the dependent amounts of the ingredients on the nonlinear, mechanical behavior of poly(N-isopropylacrylamide).

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“…The reason for the glucose sensitivity of phenylboronic acid is that there are two equilibrium forms of PBA in aqueous solutions: the first is a neutral and hydrophobic form with a planar triangular structure, and the second is a charged and hydrophilic form with a tetrahedral structure . Specific interactions between charged PBA components and cis-glycol compounds (e.g., glucose) can form reversible glucose-boronate complexes, , which can cause the movement of the ionization balance, increase the charge and hydrophilicity, lead to matrix swelling and release payload. − Accordingly, polymers based on PBA in the form of hydrogels, − microgels, − nanogels, , thin films, , micelles, ,, vesicles, , and nanoparticles (NPs) − have been synthesized. Compared to other systems, self-assembled nanoparticles with a core–shell structure have higher drug-loading capacity and drug-loading efficiency, longer circulation time in vivo, greater modifiability, higher bioavailability, etc. , As a result, phenylboronic acid and its derivative-based polymeric nanoparticles as glucose-responsive systems have been actively investigated. ,,,,− Among these PBA-based glucose-responsive systems, block copolymers have drawn much attention for their regular structures and easy self-assembling to core–shell nanoparticles. ,,,− For example, Jin et al synthesized a PBA-based thermoresponsive, glucose-responsive, and pH-responsive block copolymer poly(ethylene oxide)- b -poly(methoxydi(ethylene glycol) methacrylate- co -aminophenylboronic acid ethyl methacrylate) (PEO- b -P(DEGMMA- co -PBAMA)) .…”

Section: Introductionmentioning

confidence: 99%

Glucose-Sensitive Polyphosphoester Diblock Copolymer for an Insulin Delivery System

Zhang

et al. 2020

ACS Biomater. Sci. Eng.

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In this study, we report a diblock copolymer based on a polyphosphate backbone and pendant phenylboronic acid with glucose sensitivity. The copolymer, abbreviated as (PBYP-g-MPBA)-b-PEEP, was prepared via a combination of ring-opening copolymerization, “click” chemistry, and amide reaction, in which the PBYP and PEEP blocks, respectively, represent two kinds of polyphosphoester structures and MPBA represents 3-mercaptopropionic acid modified with 3-aminophenylboronic acid. The amphiphilic copolymer (PBYP-g-MPBA)-b-PEEP could self-assemble into core–shell nanoparticles (NPs) in aqueous solutions. The average particle size and morphology of the NPs were measured by dynamic light scattering and transmission electron microscopy, respectively. The phenomenon that the NPs swelled at different glucose concentrations is due to the formation of boronate esters between the diol groups of glucose and boronic acid groups of phenylboronic acid. Fluorescein isothiocyanate (FITC)–insulin was loaded into the NPs and triggered to release in the presence of glucose. The more the glucose in the release media, the more the FITC–insulin released and the faster the release rate. Methyl thiazolyl tetrazolium assays and hemolysis tests proved that the (PBYP-g-MPBA)-b-PEEP copolymers had good biocompatibility. All of these results verify that the glucose-sensitive polyphosphoester diblock copolymer is highly promising for an insulin delivery system.

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A simplified model for equilibrium and transient swelling of thermo-responsive gels

Cited by 12 publications

References 51 publications

Volume Phase Transition in Gels: Its Discovery and Development

Volume Phase Transition in Gels: Its Discovery and Development

Mechanical and microstructural characterization of poly(N-isopropylacrylamide) hydrogels and its nanocomposites

Glucose-Sensitive Polyphosphoester Diblock Copolymer for an Insulin Delivery System

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