A simulation study for radiation treatment planning based on the atomic physics of the proton-boron fusion reaction

Kim, Sunmi; Yoon, Do-Kun; Shin, Han-Back; Jung, Jin‐Woo; Kim, Moo-Sub; Kim, Kyeong-Hyeon; Jang, Hong-Seok; Suh, Tae Suk

doi:10.3938/jkps.70.629

Cited by 3 publications

(4 citation statements)

References 30 publications

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“…And also how much is the proton dose enhancement by the produced alpha particles? In fact, the current study contests the results of specific literatures 1,[3][4][5] in terms of physical scientific basis and validity of the MCNPX simulation. Therefore, the cross section of the 11 B(p,α)2α reaction, as well as simulation of interaction between proton beam and a BUR inside a water phantom, was investigated.…”

Section: Introductionsupporting

confidence: 68%

“…The proton beam energy in our study was 80 MeV that is similar to 1,3-5 the 80-MeV 1 ; 60-, 70-, 80-, 90-MeV 3 ; 60-to 120-MeV 4 ; 75-to 85-MeV 5 protons that were used in the mentioned papers. Furthermore, they used pure 11 B cubics 1,3,4 as proton dose booster, which was done in the current work as well. However, no enhancement was seen in the proton 'dose' that has a full agreement with the physical basis of the low cross-section fusion of 11 B.…”

Section: Discussionmentioning

confidence: 99%

“…The maximum non-toxic concentration of boron in tumour is under 100 μg/g, [17][18][19] but the literature concentrations were hundreds of clinical values, varied from 1 g/g (100%) 1,4 to 1•04 mg/g 5 and 25 mg/g. 3 As shown in Figures 6 and 7, the alpha particles' Bragg peak had a neglectable amplitude in comparison with the protons dose.…”

Section: Discussionmentioning

confidence: 99%

“…In March 2017, the same researchers presented the results of treatment planning simulation for a simple phantom that had volumes for planning target volume (PTV) and organ at risk (OAR). 4 Again, they used a cubic BUR with pure 11 B. They reported the dose increment to PTV and better sparing of the OAR in the cases with BUR placement.…”

Section: Introductionmentioning

confidence: 99%

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Is the proton–boron fusion therapy effective?

et al. 2020

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Introduction: In the recent years, some publications (mainly from one group of authors) have dealt with the effectiveness of proton–boron fusion therapy (PBFT). This theory is based on the Q-value of three produced α particles in the reaction of protons with boron (11B). They claim that this reaction significantly increases the absorbed dose in the target volume. However, the current study would re-evaluate their method to show if PBFT is really effective. Methods and materials: A parallel 80-MeV proton beam was irradiated on a water medium in a cubic boron uptake region (BUR). The two-dimensional dose distribution and percentage depth dose of protons, alphas and all particles were calculated using tally F6 and mesh-tallies by Monte Carlo N Particle Transport code. Results: The results not only showed that the dose enhancement in BUR is neglectable but also the higher density of BUR in comparison with water led to decrement of dose in this region. Because of low cross section of boron for proton beam (<100 mb), the α particles’ dose is 1,000 times lower than the proton dose. Conclusions: The physical aspects and the simulation results did not show any effectiveness of the PBFT for proton therapy dose enhancement.

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Section: Introductionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%