A Single Dose of Ibuprofen Impacts IL-10 Response to 164-km Road Cycling in the Heat

Vingren, Jakob L.; Boyett, James C.; Lee, E C; Levitt, Danielle E.; Luk, Hui‐Ying; McDermott, Brendon P.; Muñoz, Colleen X.; Ganio, Matthew S.; Armstrong, Lawrence E.; Hill, David W.

doi:10.1080/02701367.2021.1981539

Cited by 5 publications

(7 citation statements)

References 36 publications

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“…IL-10 is also an important immune system regulator in the human body. It plays an important role in the pathogenesis of various diseases and is currently recognized by the medical community as an immunosuppressive factor [29][30][31][32]. TNF-α is a multifunctional inflammatory cytokine, mainly produced by eosinophils and monocytes, and has anti-infective effects.…”

Section: Computational and Mathematical Methods In Medicinementioning

confidence: 99%

Effect of Vitapex Combined with AH-Plus Paste on Inflammation in Middle-Aged and Elderly Patients with Periodontal-Endodontic Disease

Zhang

Guo

et al. 2022

Computational and Mathematical Methods in Medicine

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Aims. To investigate the effect of Vitapex combined with AH-plus paste on inflammation in middle-aged and elderly patients with periodontal-endodontic disease. Materials and Methods. A total of 80 teeth of middle-aged and elderly patients with the periodontal-endodontic disease who were treated in our hospital from June 2020 to June 2021 were selected as the research objects and were divided into comparison group and treatment group with 40 teeth each according to different treatment methods. Among them, the comparison group was filled with zinc oxide clove oil paste gutta-percha, and the treatment group was filled with Vitapex combined with AH-plus paste. The changes in apical cross-section sealing performance, periodontal pocket depth (PD), and gingival index (GI) of the two groups before treatment and after 6 months of follow-up were observed and compared, and X-ray analysis was performed. Results. There was no significant difference in the level of periodontal indexes and serum inflammatory indexes between the two groups before treatment ( P > 0.05 ). After treatment, the levels of PD, BI, PLI, and GI in the two groups were significantly lower than before treatment ( P < 0.05 ). The differences in IL-6, IL-10, TNF-α, and IL-1β after treatment were significant ( P < 0.05 ). There was no significant difference in the root canal area data of each cross-section between the two groups when the root canal was filled with root filling paste at different positions from the apex ( P > 0.05 ). After root canal filling with root canal paste, the cross-sectional area from different parts of the root canal in the treatment group was significantly smaller than comparison group ( P < 0.05 ). After 6 months of treatment, it was found that CEJ-BD and CEJ-AC in the treatment group were significantly lower than those in the comparison group ( P < 0.05 ). Conclusion. Vitapex combined with AH-plus paste filling can effectively treat middle-aged and elderly periodontal-endodontic disease, which provides a certain reference for the clinical treatment of middle-aged and elderly periodontal-endodontic disease.

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Section: Computational and Mathematical Methods In Medicinementioning

confidence: 99%

Effect of Vitapex Combined with AH-Plus Paste on Inflammation in Middle-Aged and Elderly Patients with Periodontal-Endodontic Disease

Zhang

Guo

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Leukocyte subsets increased. Thus, it appears that the consumption of ibuprofen tends to attenuate anti-inflammatory cytokine IL-10 increases but would not alter leukocyte subset concentrations [ 59 ]. Perhaps an explanation for this is that Paralympic athletes have a greater amount of body musculature involved in strength training, such as the bench press, as mentioned in another study regarding hemodynamic variation in conventional and Paralympic powerlifting athletes, which would explain part of the findings in our study [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Ibuprofen Use on the Immune System Indicators and Force in Disabled Paralympic Powerlifters of Different Sport Levels

et al. 2022

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Background: Paralympic powerlifting (PP) training is typically intense and causes fatigue and alterations in the immune system. Objective: To analyze whether IBU would affect performance and the immune system after training in PP. Methodology: 10 athletes at the national level (NL) and 10 at the regional level (RL) participated in the study, where force and blood indicators were evaluated after training. The study took place over three weeks: (1) familiarization and (2 and 3) comparison between recovery methods, with ibuprofen or placebo (IBU vs. PLA), 800 mg. In the evaluation of the force, the peak torque (PT), fatigue index (FI), and blood immune system biomarkers were analyzed. The training consisted of five sets of five repetitions with 80% of one maximum repetition (5 × 5, 80% 1RM) on the bench press. Results: The PT at the national level using IBU was higher than with PLA (p = 0.007, η2p = 0.347), and the FI in the NL was lower with IBU than with PLA (p = 0.002, η2p = 0.635), and when comparing the use of IBU, the NL showed less fatigue than the regional level (p = 0.004, η2p = 0.414). Leukocytes, with the use of IBU in the NL group, were greater than in the RL (p = 0.001, η2p = 0.329). Neutrophils, in the NL with IBU, were greater than in the RL with IBU and PLA (p = 0.025, η2p = 0.444). Lymphocytes, in NL with IBU were lower than in RL with IBU and PLA (p = 0.001, η2p = 0.491). Monocytes, in the NL with IBU and PLA, were lower than in the RL with IBU (p = 0.049, η2p = 0.344). For hemoglobin, hematocrit, and erythrocyte, the NL with IBU and PLA were higher than the RL with IBU and PLA (p < 0.05). Ammonia, with the use of IBU in the NL, obtained values higher than in the RL (p = 0.007), and with the use of PLA, the NL was higher than the RL (p = 0.038, η2p = 0.570). Conclusion: The training level tends to influence the immune system and, combined with the use of the IBU, it tends to improve recovery and the immune system.

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“…Using a syngeneic (D2A1) orthotopic Balb-c mouse model, ibuprofen reduced the infiltration of immature monocytes into tumors implanted in the mammary involution. Despite the anti-inflammatory character of nonsteroidal anti-inflammatory drugs, some studies show that the use of COX inhibitors decreases the levels of anti-inflammatory cytokines such as IL-10 [85]. It is conceivable that the use of COX inhibitors does not simply reduce inflammation, but rather modulates inflammation in ways that are clinically beneficial.…”

Section: Macrophages and Cyclooxygenase Inhibitorsmentioning

confidence: 99%

Impact of Lipid Metabolism on Macrophage Polarization: Implications for Inflammation and Tumor Immunity

Vassiliou

Farias-Pereira

2023

IJMS

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Macrophage polarization is influenced by lipids, which also exert significant control over macrophage functions. Lipids and their metabolites are players in intricate signaling pathways that modulate macrophages’ responses to pathogens, phagocytosis, ferroptosis, and inflammation. This review focuses on lipid metabolism and macrophage functions and addresses potential molecular targets for the treatment of macrophage-related diseases. While lipogenesis is crucial for lipid accumulation and phagocytosis in M1 macrophages, M2 macrophages likely rely on fatty acid β-oxidation to utilize fatty acids as their primary energy source. Cholesterol metabolism, regulated by factors such as SREBPs, PPARs, and LXRs, is associated with the cholesterol efflux capacity and the formation of foam cells (M2-like macrophages). Foam cells, which are targets for atherosclerosis, are associated with an increase in inflammatory cytokines. Lipolysis and fatty acid uptake markers, such as CD36, also contribute to the production of cytokines. Enhancing the immune system through the inhibition of lipid-metabolism-related factors can potentially serve as a targeted approach against tumor cells. Cyclooxygenase inhibitors, which block the conversion of arachidonic acid into various inflammatory mediators, influence macrophage polarization and have generated attention in cancer research.

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A Single Dose of Ibuprofen Impacts IL-10 Response to 164-km Road Cycling in the Heat

Cited by 5 publications

References 36 publications

Effect of Vitapex Combined with AH-Plus Paste on Inflammation in Middle-Aged and Elderly Patients with Periodontal-Endodontic Disease

Effect of Vitapex Combined with AH-Plus Paste on Inflammation in Middle-Aged and Elderly Patients with Periodontal-Endodontic Disease

Evaluation of Ibuprofen Use on the Immune System Indicators and Force in Disabled Paralympic Powerlifters of Different Sport Levels

Impact of Lipid Metabolism on Macrophage Polarization: Implications for Inflammation and Tumor Immunity

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