A single exposure of rats to water-immersion restraint stress induces oxidative stress more severely in the thymus than in the spleen

Ohta, Yoshiji; Yashiro, Koji; Hidaka, Mayumi; Honda, Minako; Imai, Yoichoro; Ohashi, Koji; Fukuzawa, Kenji

doi:10.1179/1351000212y.0000000023

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Clearly, it is difficult to tease apart the differential modulation and generation of the CD8 + CD122 + T cell response during pregnancy, as CD8 + CD122 + T cell frequencies remained low upon supplemental progesterone and associated placental Hmox1 upregulation in stress-challenged dams. This observation suggests that Hmox1-independent mechanisms, such as direct effects on maternal thymus (73,74), low levels of TGF-β (75), or selective glucocorticoid-induced CD8 + Treg apoptosis in response to stress, could account for the impaired generation of this cell subset.…”

Section: Discussionmentioning

confidence: 99%

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation

Solano¹,

Kowal²,

O’Rourke³

et al. 2015

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation

Solano¹,

Kowal²,

O’Rourke³

et al. 2015

J. Clin. Invest.

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“…Plasma epinephrine and norepinephrine levels were increased via the activation of the plasma enzymes in fasted rats under 6 h of WIRS ( Arakawa et al., 1997 ). Ohta et al demonstrated that WIRS exposure of rats induced severe oxidative stress in immune organs ( Ohta et al., 2012 ). However, the pathogenesis of intestinal mucosal injury induced by water restraint stress remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Acute Cold Water-Immersion Restraint Stress Induces Intestinal Injury and Reduces the Diversity of Gut Microbiota in Mice

Yuan

Liu

et al. 2021

Front. Cell. Infect. Microbiol.

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Growing evidence has demonstrated that stress triggers gastrointestinal (GI) disorders. This study aimed to investigate how the acute cold water-immersion restraint (CWIR) stress affects intestinal injury and gut microbiota (GM) distribution. Male C57BL/6 mice were used to establish a CWIR animal model. Hematoxylin–eosin and periodic acid–Schiff staining were performed to assess intestinal histopathological changes. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis and immunofluorescence staining were used to evaluate the expression of inflammatory cytokines and immune cell infiltration in the intestinal tissues. The gut permeability and intestinal occludin protein expression were determined through fluorescein isothiocyanate-dextran detection and western blot, respectively. GM profiles were analyzed via high-throughput sequencing of the fecal bacterial 16S rRNA genes. Results showed that CWIR induced more severe intestinal mucosal injury compared to the control, leading to a significant increase in tumor necrosis factor-α expression, but no infiltration of neutrophil and T cells. CWIR also resulted in GI disruption and increased the permeability of the intestinal mucosa. GM profiles showed that CWIR reduced GM diversity of mice compared with the control group. Specifically, aerobic and gram-negative bacteria significantly increased after CWIR, which was associated with the severity of gut injury under stress. Therefore, acute CWIR leads to severe intestinal damage with inflammation and disrupts the GM homeostasis, contributing to decreased GM diversity. Our findings provide the theoretical basis for the further treatment of intestinal disorders induced by CWIR.

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Hydroxy Selenomethionine Exert Different Protective Effects Against Dietary Oxidative Stress–Induced Inflammatory Responses in Spleen and Thymus of Pigs

Jing,

Xiang,

Tang

et al. 2023

Biol Trace Elem Res

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A single exposure of rats to water-immersion restraint stress induces oxidative stress more severely in the thymus than in the spleen

Abstract: It is indicated that a single expose of rats to WIRS induces oxidative stress more severely in the thymus than in the spleen.

Cited by 4 publications

References 22 publications

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation

Acute Cold Water-Immersion Restraint Stress Induces Intestinal Injury and Reduces the Diversity of Gut Microbiota in Mice

Hydroxy Selenomethionine Exert Different Protective Effects Against Dietary Oxidative Stress–Induced Inflammatory Responses in Spleen and Thymus of Pigs

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