A single high dose of escitalopram increases mismatch negativity without affecting processing negativity or P300 amplitude in healthy volunteers

Wienberg, Malene; Glenthøj, Birte; Jensen, Kristian; Oranje, Bob

doi:10.1177/0269881109102606

Cited by 63 publications

(43 citation statements)

References 55 publications

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“…The study by Van Laar et al mentioned above also included the SSRI paroxetine (30 mg) and the non-specific 5-HT2 antagonist nefazodone (200 mg) but did not find any effect. Consistent acute nil effects have also been reported for 15 mg escitolapram (Wienberg et al, 2010), as well as in older studies using methysergide (Meador et al, 1989), and fenfluramine (Pritchard et al, 1987). Inconsistently, McAllister-Williams et al (2002) found larger P300s after ATD.…”

Section: 'Attention' and Memory Updating: P300supporting

confidence: 77%

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

Kenemans

Kähkönen

2010

Neuropsychopharmacol

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This review surveys human event-related brain potential (ERP) and event-related magnetic field (ERF) approaches to psychopharmacology and psychopathology, and the way in which they complement behavioral studies and other neuroimaging modalities. The major paradigms involving ERP/ERF are P50 suppression, loudness-dependent auditory evoked potential (LDAEP), mismatch negativity (MMN), P300, mental chronometry, inhibitory control, and conflict processing (eg, error-related negativity (ERN)). Together these paradigms cover a range of more bottom-up driven to more top-down controlled processes. A number of relationships between the major neurotransmitter systems and electrocortical mechanisms are highlighted. These include the role of dopamine in conflict processing, and perceptual processing vs motor preparation; the role of serotonin in P50 suppression, LDAEP, and MMN; glutamate/NMDA and MMN; and the role of acetylcholine in P300 generation and memory-related processes. A preliminary taxonomy for these relationships is provided, which should be helpful in attuning possible new treatments or new applications of existing treatments to various disorders.

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Section: 'Attention' and Memory Updating: P300supporting

confidence: 77%

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

Kenemans

Kähkönen

2010

Neuropsychopharmacol

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“…For the P3, it has repeatedly been shown that this component does not depend on the serotonergic system (e.g. Oranje et al, 2008;Wienberg et al, 2009). The pattern observed for the Pe nicely fits to this.…”

Section: Discussionmentioning

confidence: 99%

Functional 5‐HT1a receptor polymorphism selectively modulates error‐specific subprocesses of performance monitoring

Beste¹,

Domschke²,

Kolev³

et al. 2010

Human Brain Mapping

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Our study investigates the dependence of response monitoring and error detection on genetic influences modulating the serotonergic system. This was done using the event-related potentials (ERPs) after error (Ne/ERN) and correct trials (Nc/CRN). To induce a sufficient amount of errors, a standard flanker task was used. The subjects (N = 94) were genotyped for the functional 5-HT1A C(-1019)G polymorphism. The results show that the 5-HT1A C(-1019)G polymorphism specifically modulates error detection. Neurophysiological modulations on error detection were paralleled by a similar modulation of response slowing after an error, reflecting the behavioral adaptation. The 5-HT1A -1019 CC genotype group showed a larger Ne and stronger posterror slowing than the CG and GG genotype groups. More general processes of performance monitoring, as reflected in the Nc/CRN, were not affected. The finding that error-specific processes, but not general response monitoring processes, are modulated by the 5-HT1A C(-1019)G polymorphism is underlined by a wavelet analysis. In summary, the results suggest a specific effect of the 5-HT1A C(-1019)G polymorphism on error monitoring, as reflected in the Ne, and suggest a neurobiological dissociation between processes of error monitoring and general response monitoring at the level of the serotonin 1A receptor system.

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“…All subjects were examined with the Copenhagen Psychophysiology Test Battery (CPTB) Jensen et al, 2008;Wienberg et al, 2010). The CPTB includes PPI, P50 suppression, mismatch negativity (MMN), and selective attention paradigms.…”

Section: Psychophysiologymentioning

confidence: 99%

Effects of Dopamine D2/D3 Blockade on Human Sensory and Sensorimotor Gating in Initially Antipsychotic-Naive, First-Episode Schizophrenia Patients

Düring

Glenthøj

Andersen

et al. 2014

Neuropsychopharmacol

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It has been suggested that psychophysiological measures of sensory and sensorimotor gating, P50 gating and prepulse inhibition of the startle reflex (PPI), underlie core features of schizophrenia and are linked to dopaminergic pathways in the striatum and prefrontal cortex. In the present study, the effects of a potent D2/D3 receptor antagonist, amisulpride, were investigated on PPI and P50 gating in a large sample of antipsychotic-naive, first-episode patients with schizophrenia. A total of 52 initially antipsychotic-naive, first-episode schizophrenia patients were assessed for their P50 gating, PPI, and habituation/sensitization abilities at baseline and after 2 and 6 weeks of treatment with flexible doses of amisulpride. In addition, 47 matched healthy controls were assessed at baseline and after 6 weeks. At baseline, the patients showed significantly reduced PPI, yet normal levels of P50 gating, habituation, and sensitization. Treatment with amisulpride showed no effects on these measures, either at 2 or 6 weeks of follow-up. This is the first study investigating the effects of monotherapy with a relatively selective dopamine D2/D3 receptor antagonist (amisulpride) on sensory and sensorimotor gating deficits in a longitudinal study of a large group of initially antipsychotic-naive, first-episode patients with schizophrenia. Our finding that amisulpride effectively reduced symptom severity in our patients without reducing their PPI deficits indicates that increased activity of dopamine D2 receptors may be involved in symptomatology of patients with schizophrenia, but not in their sensorimotor gating deficits.

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A single high dose of escitalopram increases mismatch negativity without affecting processing negativity or P300 amplitude in healthy volunteers

Cited by 63 publications

References 55 publications

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

Functional 5‐HT1a receptor polymorphism selectively modulates error‐specific subprocesses of performance monitoring

Effects of Dopamine D2/D3 Blockade on Human Sensory and Sensorimotor Gating in Initially Antipsychotic-Naive, First-Episode Schizophrenia Patients

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