2009
DOI: 10.1007/s00467-008-1041-5
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A single high dose of ergocalciferol can be used to boost 25-hydroxyvitamin D levels in children with kidney disease

Abstract: Sirs,We read with great interest the study by Menon et al. regarding concentrations of serum 25-hydroxyvitamin D [25(OH)D; a measure of body stores of vitamin D] and hyperparathyroidism in children with chronic kidney disease [1]. The authors found that 77.2% of their patients with chronic kidney disease were vitamin D deficient/ insufficient, as defined by serum 25-hydroxycholecalciferol [25(OH)D3] levels of less than 30 ng/ml. Twenty-two of these patients received treatment with ergocalciferol, based on thei… Show more

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Cited by 19 publications
(21 citation statements)
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“…Serum 25(OH)D levels improved from a baseline of 1.5-15.8 to 7-25.6 ng/ml after 3 months. Of note, none of the patients achieved levels above 30 ng/ml (75 nmol/L), and the effect of increased 25(OH)D on PTH levels was not mentioned (40). Hari et al (15) report a similarly high prevalence of 25(OH)D deficiency of 82% in Indian children with CKD stages 2-4, and treatment with cholecalciferol (600,000 IU orally over 4 days) improved 25(OH)D levels above 75 nmol/L, with a parallel improvement in PTH levels into the normal range (15).…”
Section: Discussionmentioning
confidence: 99%
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“…Serum 25(OH)D levels improved from a baseline of 1.5-15.8 to 7-25.6 ng/ml after 3 months. Of note, none of the patients achieved levels above 30 ng/ml (75 nmol/L), and the effect of increased 25(OH)D on PTH levels was not mentioned (40). Hari et al (15) report a similarly high prevalence of 25(OH)D deficiency of 82% in Indian children with CKD stages 2-4, and treatment with cholecalciferol (600,000 IU orally over 4 days) improved 25(OH)D levels above 75 nmol/L, with a parallel improvement in PTH levels into the normal range (15).…”
Section: Discussionmentioning
confidence: 99%
“…The current literature on ergocalciferol or cholecalciferol supplementation in adults and children (15,16,40) with predialysis CKD consists of small, mostly nonrandomized and short-term studies using (26)(27)(28)(29)(30)(31)(32) variable doses of ergocalciferol or cholecalciferol, and it is difficult to draw any clinical practice recommendations from these studies. Ergocalciferol or cholecalciferol have been used in daily (28,31), weekly (26,28,32), monthly (16,27,29,30), and even single mega dose (15,40) therapy.…”
Section: Discussionmentioning
confidence: 99%
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“…At the present time, it seems prudent to maintain serum levels 25(OH)D and 1,25(OH) 2 D in the upper normal range. Of note, nutritional vitamin D insufficiency states should be treated with rather high doses of D2 or D3, but pediatric experience is currently limited [128,167]. In addition, in view of the importance of DBP levels in delivering 25(OH)D to the kidney and peripheral tissues, vitamin D dosages should be reevaluated for patients on peritoneal dialysis [168] and with persistent nephrotic syndrome [169].…”
Section: Other Vdr Activatorsmentioning
confidence: 99%