A single injection of immature dendritic cells is able to induce antitumour response against a murine colon adenocarcinoma with a low apoptotic index

Jalili, Ahmad; Stokłosa, Tomasz; Giermasz, Adam; Olszewska, Dominika; Wilczyński, Grzegorz M.; Jakóbisiak, Marek; Gołąb, Jakub

doi:10.3892/or.9.5.991

Cited by 9 publications

(7 citation statements)

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“…DCs were isolated and cultured according to the method of Inaba et al (20) and as described previously (21). Briefly, DCs were obtained from bone marrow precursors by flushing femur, tibia, and humerus bones of 8 -10-week-old BALB/c mice with cold PBS.…”

Section: Methodsmentioning

confidence: 99%

Effective Photoimmunotherapy of Murine Colon Carcinoma Induced by the Combination of Photodynamic Therapy and Dendritic Cells

Jalili

Makowski

Świtaj

et al. 2004

Clinical Cancer Research

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141

109

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Section: Methodsmentioning

confidence: 99%

Effective Photoimmunotherapy of Murine Colon Carcinoma Induced by the Combination of Photodynamic Therapy and Dendritic Cells

Jalili

Makowski

Świtaj

et al. 2004

Clinical Cancer Research

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141

109

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“…Cellular therapy (1) based on the injection of immune cells is a very promising approach to the treatment of many diseases. Immunotherapy can be used to induce an efficient specific response to solid tumors of the colon (2) and lung (3), or to hematopoietic cancers such as leukemia (4–6), lymphoma (7, 8), and myeloma (9).…”

mentioning

confidence: 99%

Differential Prognostic Effect of Revascularization According to a Simple Comorbidity Index in High‐Risk Non–ST‐Segment Elevation Acute Coronary Syndrome

Palau

Núñez

Sanchís

et al. 2011

Clinical Cardiology

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Background: Data on the effect of revascularization on outcome in patients with high-risk non-ST-segment elevation acute coronary syndrome (NSTEACS) and significant comorbidities are scarce. Recently, a simple comorbidity index (SCI) including 5 comorbidities (renal failure, dementia, peripheral artery disease, heart failure, and prior myocardial infarction [MI]) has shown to be a useful tool for risk stratification. . In multivariate analysis, a differential prognostic effect of revascularization was observed comparing SCI ≥2 vs 0 (P for interaction = 0.008). Thus, revascularization was associated with a greater prognostic benefit in patients with SCI ≥2 (hazard ratio [HR]: 0.51, 95% confidence interval [CI]: 0.29-0.89), P = 0.018), whereas no significant benefit was observed in those with 0 and 1 point (HR: 1.31, 95% CI: 0.88-1.94, P = 0.171 and HR: 1.11, 95% CI: 0.70-1.76, P = 0.651, respectively). Conclusions: In NSTEACS, the SCI score appears to be a useful tool for identifying a subset of patients with a significant long-term death/MI risk reduction attributable to revascularization. IntroductionDespite current guidelines recommending an early revascularization invasive strategy (RIS) in high-risk non-ST-segment elevation acute coronary syndrome (NSTEACS), randomized trials comparing the impact of a conservative or selective invasive strategy (CS) versus

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“…Adoptive transfer of PMO obtained from thya1 administered mice was carried out by following the method described by Jalali et al [25] DL (1 Â 10 5 cells/mouse)-transplanted mice in a group of six each were administered with a single i.p. injection of 1 Â 10 6 PMO in 500 mL of PBS on day 8 posttumor transplantation, and the progression of tumor was monitored as per survival of the tumor-bearing mice.…”

Section: Adoptive Transfer Experimentsmentioning

confidence: 99%

Antitumor Activation of Peritoneal Macrophages by Thymosin Alpha-1

Shrivastava

Singh

2005

LCNV

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It was been previously reported that thya1 can be used to activate monocytes, BMDM and TAM. However, the effect of thya1 on other tissue macrophages has not been investigated. Moreover, there is no report about the use of thya1-treated macrophages in adoptive immunotherapy of cancer. In view of these observations in the present study, we checked the response of various tissue macrophages to thya1 for activation. Tissue macrophages showed differential response to thya1; moreover, adoptive transfer of peritoneal macrophages treated with thya1 to mice bearing spontaneous T-cell lymphoma designated as Dalton's lymphoma (DL) resulted in the prolongation of the survival time of tumor-bearing mice. The mechanism of macrophage therapy-dependent tumor regression was enhanced antitumor activity of macrophages in response to thya1 treatment via their production of macrophage-activating cytokines that act in autocrine manner. These results will help in the development of immunotherapy against tumor based on activation of macrophage with thya1.

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A single injection of immature dendritic cells is able to induce antitumour response against a murine colon adenocarcinoma with a low apoptotic index

Cited by 9 publications

References 0 publications

Effective Photoimmunotherapy of Murine Colon Carcinoma Induced by the Combination of Photodynamic Therapy and Dendritic Cells

Effective Photoimmunotherapy of Murine Colon Carcinoma Induced by the Combination of Photodynamic Therapy and Dendritic Cells

Differential Prognostic Effect of Revascularization According to a Simple Comorbidity Index in High‐Risk Non–ST‐Segment Elevation Acute Coronary Syndrome

Antitumor Activation of Peritoneal Macrophages by Thymosin Alpha-1

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