A Singlet Oxygen Generating Agent by Chirality‐dependent Plasmonic Shell‐Satellite Nanoassembly

Abstract

Photodynamic therapy (PDT) agent, which generates singlet oxygen (1O2) under light, has attracted significant attention for its broad biological and medical applications. Here, DNA‐driven shell–satellite (SS) gold assemblies as chiral photosensitizers are first fabricated. The chiral plasmonic nanostructure, coupling with cysteine enantiomers on its surface, exhibits intense chiroplasmonic activities (−40.2 ± 2.6 mdeg) in the visible region. These chiral SS nanoassemblies have high reactive oxygen species generating efficiency under circular polarized light illumination, resulting in a 1O2 quantum yield of 1.09. Meanwhile, it is found that SS could be utilized as PDT agent with remarkable efficiency under right circular polarized light irradiation in vitro and in vivo, allowing X‐ray computed tomography (CT) and photoacoustics (PA) imaging for tumors simultaneously. The achievements reveal that the enantiomer‐dependent and structure‐induced nanoassemblies play an important role in PDT effects. The present researches open up a new avenue for cancer diagnose and therapy using chiral nanostructures as multifunctional platform.

Chiral Shell Core–Satellite Nanostructures for Ultrasensitive Detection of Mycotoxin

“…It is worth noting that only the assembled core–satellite structure had a chiral signal. We recently discovered that there is a small dihedral angle between the core and satellite NPs . The asymmetric dipole–dipole interaction between nanoparticles causes the core–satellite structure to produce a strong chiral signal.…”

“…We recently discovered that there is a small dihedral angle between the core Small 2018, 14, 1703931 and satellite NPs. [45] The asymmetric dipole-dipole interaction between nanoparticles causes the core-satellite structure to produce a strong chiral signal.…”

AIE Multinuclear Ir(III) Complexes for Biocompatible Organic Nanoparticles with Highly Enhanced Photodynamic Performance

“…Photodynamic therapy (PDT) has attracted great attention in recent years due to the noninvasive nature, high specificity, controllability, and insignificant side effects compared with traditional surgery, chemotherapy, and radiotherapy . The key element for PDT is that highly cytotoxic reactive oxygen species (ROS) generated by the photosensitizers (PSs) upon irradiation lead to cell apoptosis and necrosis .…”

The Fabrication of rGO/(PLL/PASP)3@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

“…[2][3] Recently,n anoscale drug carriers have been reported as an effective methodt oc ircumvent MDR and they offer ar emarkable intracellulard rug delivery mechanism to improvea nticancer efficacy. [4][5][6][7][8][9][10] Reduced graphene-based drug-delivery systems have attracted the most attention because of their unique physical, electrical and chemicalp roperties, andt hey have been widely used as biomedical treatments, particularly for use in photothermal therapy( PTT) and cell imaging. [11][12][13][14][15][16][17][18][19][20][21][22] PTT is one of the mostp rominentm ethods for the application of rGO-based nanodrug systems.…”