A six‐month randomized controlled trial of exercise and pyridostigmine in the treatment of fibromyalgia

Abstract

Objective. A subset of fibromyalgia (FM) patients have a dysfunctional hypothalamic-pituitary-insulinlike growth factor 1 (IGF-1) axis, as evidenced by low serum levels of IGF-1 and a reduced growth hormone (GH) response to physiologic stimuli. There is evidence that pyridostigmine (PYD) improves the acute response of GH to exercise in FM patients. The purpose of this study was to evaluate the clinical effectiveness of 6 months of PYD and group exercise on FM symptoms.Methods. FM patients were randomized to 1 of the following 4 groups: PYD plus exercise, PYD plus diet recall but no exercise, placebo plus exercise, and placebo plus diet recall but no exercise. The primary outcome measures were the visual analog scale (VAS) score for pain, tender point count, and total myalgic score. Secondary outcome measures were the total score on the Fibromyalgia Impact Questionnaire (FIQ) and FIQ VAS scores for individual symptoms (fatigue, poor sleep, stiffness, and anxiety), as well as quality of life (QOL) and physical fitness (lower body strength/ endurance, upper and lower body flexibility, balance, and time on the treadmill).Results. A total of 165 FM patients completed baseline measurements; 154 (93.3%) completed the study. The combination of PYD and exercise did not improve pain scores. PYD groups showed a significant improvement in sleep and anxiety in those who completed the study and in QOL in those who complied with the therapeutic regimen as compared with the placebo groups. Compared with the nonexercise groups, the 2 exercise groups demonstrated improvement in fatigue and fitness. PYD was generally well tolerated.Conclusion. Neither the combination of PYD plus supervised exercise nor either treatment alone yielded improvement in most FM symptoms. However, PYD did improve anxiety and sleep, and exercise improved fatigue and fitness. We speculate that PYD may have improved vagal tone, thus benefiting sleep and anxiety; this notion warrants further study.

Effectiveness of physical activity in reducing pain in patients with fibromyalgia: a blinded randomized clinical trial

“…Care was taken in the design of the study protocol [18]; all patients underwent clinical examination at monthly intervals; and medication for Wbromyalgia was restarted if necessary. Patients in the WA and MS groups took less medication, which is consistent with the Wndings of other study, which had reported that the aerobic exercise group took fewer analgesics than did the controls [12].…”

“…However, these studies have used diVerent combinations of exercise modalities [10][11][12][13], making it diYcult to determine which modality is in fact eVective. There are few evidences that strengthening exercises, as a single modality [1,[14][15][16][17], improve Wbromyalgia symptoms.…”

Fibromyalgia Syndrome: Novel Therapeutic Targets

“…Pyridostigmine, a medication which increases the secretion of endogenous growth hormone, has been tested in FMS but did not show efficacy [59]. In a trial testing the interaction of pyridostigmine (mestinon) and exercise in FMS, the group treated with pyridostigmine showed improvement in parameters of anxiety and sleep, while exercise improved fatigue and fitness [60].…”

Emerging therapies for fibromyalgia: an update

“…Pyridostigmine, a medication which increases the secretion of endogenous growth hormone, has been tested in FMS but did not show efficacy [120].…”