A six-year-old boy with autism and left hip pain

Erdle, Stephanie; Conway, Melanie; Weinstein, Michael

doi:10.1503/cmaj.160712

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…Despite often being thought of as a disease of the past, scurvy (the disease associated with severe vitamin C deficiency) has been described recently in an infant fed exclusively almond beverage (Vitoria et al, 2016), in a child receiving peritoneal dialysis (Kittisakmontri et al, 2016), and in children with neurodevelopmental disability (Weinstein et al, 2001;Erdle et al, 2017;Harknett et al, 2014). Children with autism spectrum disorder (ASD) may be at higher risk of scurvy, as well as other micronutrient deficiencies, because of restricted diet and limited food repertoire; however, there are no published studies on the frequency at of vitamin C deficiency in the paediatric ASD population.…”

Section: Introductionmentioning

confidence: 99%

Scurvy as a mimicker of osteomyelitis in a child with autism spectrum disorder

Kinlin

Blanchard

Silver

et al. 2018

International Journal of Infectious Diseases

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A case of scurvy in a 10-year-old boy with autism spectrum disorder is described. His clinical presentation was initially thought to be due to osteomyelitis, for which empirical antimicrobial therapy was initiated. Further invasive and ultimately unnecessary investigations were avoided when scurvy was considered in the context of a restricted diet and classic signs of vitamin C deficiency. Infectious diseases specialists should be aware of scurvy as an important mimicker of osteoarticular infections when involved in the care of patients at risk of nutritional deficiencies.

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Section: Introductionmentioning

confidence: 99%

Scurvy as a mimicker of osteomyelitis in a child with autism spectrum disorder

Kinlin

Blanchard

Silver

et al. 2018

International Journal of Infectious Diseases

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“…In the 79 cases of scurvy we identified, the frequency of an underlying developmental condition, particularly ASD, is striking. Presumably, ASD leads to scurvy via restricted diet and limited food repertoire, which can be manifestations of this neurodevelopmental condition 50,75 . Restricted diet was essentially universal in the cases of scurvy we identified, in both children with ASD and previously healthy children.…”

Section: Discussionmentioning

confidence: 75%

“…Literature reviewed yielded 77 cases of scurvy described in 65 published papers (Table S1), in addition to the two cases described here 1,8,9,11‐73 …”

Section: Literature Reviewmentioning

confidence: 99%

The risk for scurvy in children with neurodevelopmental disorders

Kothari¹,

Tate

Adewumi

et al. 2020

Special Care in Dentistry

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Background: Scurvy, the disease resulting from vitamin C deficiency, is perceived as being rare and occurring predominantly in the past. However, scurvy continues to exist and may be encountered in children with medical/developmental conditions and/or restricted diet. Diagnosis can be challenging given the perceived rarity of the condition and nonspecific symptoms, including gingival disease. Methods:We present a series of two cases of scurvy in which the affected children presented to medical attention with dental complaints. Additional cases of scurvy are described, based on the literature review of case reports/series published in the last 10 years.

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“…In my clinical experience, one can expect normalization of the patient's hemoglobin within 2 to 8 weeks of starting vitamin C supplementation. 13,14 However, in this patient, the hemoglobin initially improved significantly but plateaued at 10.2 g/dL after 8 weeks of vitamin C supplementation. As well, only minimal improvement was noted in the iron studies (Table 3).…”

Section: Dr Weinsteinmentioning

confidence: 69%

A Toddler With Treatment-Resistant Iron Deficiency Anemia

Conway¹,

Marcon²,

Meinert³

et al. 2018

Pediatrics

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A 19-month-old girl with a history of asthma and atopic dermatitis presented to her pediatrician because of parental concerns of pallor and fatigue. On dietary history, it was discovered that she was a picky eater and consumed 26 oz of homogenous milk daily. Her physical examination was unremarkable aside from pallor, and both her height and weight plotted between the 50th and 75th percentile for age. Therefore, she was investigated for iron deficiency anemia and indeed her blood work was consistent. Despite appropriate iron supplementation and dietary milk restriction, there was no improvement in her hemoglobin or iron studies. Our expert panel examines the case and offers a differential diagnosis for a child presenting with treatment-resistant iron deficiency anemia.

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A six-year-old boy with autism and left hip pain

Cited by 7 publications

References 9 publications

Scurvy as a mimicker of osteomyelitis in a child with autism spectrum disorder

Scurvy as a mimicker of osteomyelitis in a child with autism spectrum disorder

The risk for scurvy in children with neurodevelopmental disorders

A Toddler With Treatment-Resistant Iron Deficiency Anemia

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