A skin irritant principle from Euphorbia matabelensis Pax

Gundidza, M; Sorg, B.; Hecker, Erich

doi:10.1016/0378-8741(93)90038-7

Cited by 11 publications

(2 citation statements)

References 5 publications

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“…Present study revealed that n-hexane extract of E. globulus also has mild antimicrobial activity against all the test microorganisms. These results supported the findings of [ 43 ] who tested the antibacterial activity of E. maidenni against K. pneumoniae . This broad spectrum activity in the present study is also in accordance with the results of [ 44 ] who analysed the essential oil composition of 12 species of Eucalyptus and tested against E. coli, S. aureus and S. cerevisiae .…”

Section: Resultssupporting

confidence: 92%

Ethnobotanical and antimicrobial study of some selected medicinal plants used in Khyber Pakhtunkhwa (KPK) as a potential source to cure infectious diseases

Khan

Abbasi

Dastagir

et al. 2014

BMC Complement Altern Med

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BackgroundPresent investigation deals with antimicrobial screening of ten medicinally important plants used by the inhabitants of district Haripur, Khyber Pakhtunkhwa (KPK) for different infectious diseases.MethodsAqueous, n-hexane and ethanolic extracts of each plant were tested for their antimicrobial activity against both Gram positive and Gram negative strains of bacteria, as well as strain of yeast. Agar well diffusion and broth dilution methods were used to determine the antimicrobial activity of different plant extracts.ResultsThe results indicated that all plants exhibited antimicrobial activity against one or more test pathogens. Interestingly, extracts of three plants showed strong and broad spectrum activity as compared to rest of the extracts which demonstrated the moderate activity. On the whole ethanolic extracts exhibited maximum antimicrobial effect than their corresponding aqueous and n-hexane extracts, when compared with standard antibiotics i.e., Streptomycin and Tetracycline. Among various extracts, only ethanloic extract of Azadirachta indica and aqueous and ethanolic extracts of Eucalyptus globulus and Bergenia ciliata and ethanolic extract of Punica granatum were found to have potentially promising activity against test microorganisms.ConclusionDifferent plant extracts show promising antimicrobial activity justifying their usage in traditional medicines. This study will be continued to identify more plants with potential antimicrobial components.

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Section: Resultssupporting

confidence: 92%

Ethnobotanical and antimicrobial study of some selected medicinal plants used in Khyber Pakhtunkhwa (KPK) as a potential source to cure infectious diseases

Khan

Abbasi

Dastagir

et al. 2014

BMC Complement Altern Med

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“…The ingenol ester exhibited irritant activity in mouse ear test. 8 As a part of our research program to discover new bioactive compounds from Euphorbia species, the chloroform-soluble fraction of a methanol extract of E. matabelensis Pax (Euphorbiaceae) was investigated. This study resulted in the isolation and structure determination of 1 diterpene (ingenol) and 2 flavonoids (naringenin and eriodictyol) from this plant.…”

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confidence: 99%

Isolation and Pharmacological Investigation of Compounds From Euphorbia matabelensis

Hammadi

Kúsz

Mwangi

et al. 2019

Natural Product Communications

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This work deals with the isolation and pharmacological investigations of compounds of Euphorbia matabelensis. After multiple separation process, including thin layer chromatography (TLC), vacuum liquid chromatography, preparative TLC, and high-performance liquid chromatography, 1 diterpene (ingenol) and 2 flavonoids (naringenin and eriodictyol) were obtained from the methanol extracts prepared from the stems and roots of the plant. The structures of the isolated compounds were determined by nuclear magnetic resonance (NMR) and MS measurements and comparison with literature data. All compounds were isolated for the first time from the plant. Eriodictyol was detected for the first time from a Euphorbia species. The compounds were tested for their antiproliferative (on HeLa, C33a, MCF-7, and MDA-MB-231 cell lines) and GIRK channel blocking activities. None of the compounds proved to be active in these test systems.

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