A Small Dose of Arginine Vasopressin in Combination with Norepinephrine is a Good Early Treatment for Uncontrolled Hemorrhagic Shock After Hemostasis

Li, Tao; Fang, Yuqiang; Zhu, Yu; Fan, Xiaoqing; Liao, Zi-fu; Chen, Feng; Liu, Liangming

doi:10.1016/j.jss.2010.02.001

Cited by 24 publications

(22 citation statements)

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“…Our previous studies showed that vascular reactivity is regulated by Rho kinase and PKCε (9,18,19,21,44,45). Whether estrogen regulates vascular reactivity associated with Rho kinase and PKCε is not known.…”

Section: Discussionmentioning

confidence: 99%

“…NORMAL RATS. Male (64) and female (64) immature-to-mature and reproductive-to-aged SpragueDawley (SD) rats (4,8,10,14,18, and 24 wk and 1 and 1.5 years; n ϭ 8 rats/sex/age group), whereby 4 wk represents immature, 8 wk-24 wk represents mature and reproductive age, respectively, and 1 year and 1.5 years represents old age, were used (2,40). On the day of experimentation, rats were anesthetized with pentobarbital sodium (50 mg/kg ip).…”

Section: Animal Studiesmentioning

confidence: 99%

“…The same amounts, ages (4,8,10,14,18, and 24 wk and 1 and 1.5 years), and sexes of SD rats as in the normal rat experiments were used in this part of the experiment (n ϭ 8 rats/sex/age group). Rats were anesthetized with pentobarbital Male and female rats (8 and 14 wk and 1.5 years) were used as representatives (whereby 8 wk represented just mature, 14 wk represented reproductive, and 1.5 years represented aged rats; n ϭ 8 rats/sex/age group) to receive exogenous supplementation of estrogen (17-␤ estradiol, 0.1 mg/kg iv) for 1 wk (once daily).…”

Section: Animal Studiesmentioning

confidence: 99%

“…Whether or not traumatic shock exhibits such differences with regard to vascular responsiveness is not clear. In a cohort of 177 healthy subjects and 842 trauma patients (21-82 years) as well as different ages (4,8,10,14,18, and 24 wk; 1 and 1.5 years) and sexes of Sprague-Dawley normal and traumatic shock rats, the age-and sex-based differences of vascular responsiveness and the underlying mechanisms were investigated. Middle-aged and young women as well as female rats of reproductive age had higher vascular responsiveness in the normal condition and a lower decrease in vascular responsiveness after traumatic shock than older men and male rats of identical age.…”

mentioning

confidence: 99%

“…Vascular responsiveness decreases significantly after severe trauma and shock, which greatly interferes with the development and outcome of trauma and shock. It is the physiologic basis for refractory hypotension (6,17,18,22,41). If age and sex differences exist with respect to vascular responsiveness in victims of trauma and shock, and if and how estrogen has affects this process, is not clear.…”

mentioning

confidence: 99%

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Age and sex differences in vascular responsiveness in healthy and trauma patients: contribution of estrogen receptor-mediated Rho kinase and PKC pathways

Xiao

Zhang

et al. 2014

American Journal of Physiology-Heart and Circulatory Physiology

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L. Age and sex differences in vascular responsiveness in healthy and trauma patients: contribution of estrogen receptor-mediated Rho kinase and PKC pathways. Am J Physiol Heart Circ Physiol 306: H1105-H1115, 2014. First published February 15, 2014 doi:10.1152/ajpheart.00645.2013.-Several medical conditions exhibit age-and sex-based differences. Whether or not traumatic shock exhibits such differences with regard to vascular responsiveness is not clear. In a cohort of 177 healthy subjects and 842 trauma patients (21-82 years) as well as different ages (4,8,10,14,18, and 24 wk; 1 and 1.5 years) and sexes of Sprague-Dawley normal and traumatic shock rats, the age-and sex-based differences of vascular responsiveness and the underlying mechanisms were investigated. Middle-aged and young women as well as female rats of reproductive age had higher vascular responsiveness in the normal condition and a lower decrease in vascular responsiveness after traumatic shock than older men and male rats of identical age. Exogenous supplementation of 17␤-estrdiol increased vascular reactivity in both male and femal rats of 8 -24 wk and preserved vascular responsiveness in rats following traumatic shock. No effect was observed in rats 1 to 1.5 years. These protective effects of estrogen were closely related to G protein-coupled receptor (GPR)30, estrogen receptor-mediated Rho kinase, and PKC pathway activation. Vascular responsiveness exhibits age-and sex-based differences in healthy subjects and trauma patients. Estrogen and its receptor (GPR30) mediated activation of Rho kinase and PKC using genomic and nongenomic mechanisms to elicit protective effects in vascular responsiveness. This finding is important for the personalized treatment for several age-and sex-related diseases involving estrogen. vascular reactivity; sex; age; estrogen; estrogen receptor; Rho kinase; PKC IN RECENT YEARS, INTEREST in studying the effects of sex hormones and gender on cardiovascular function has been growing. Basic and clinical investigations have shown important differences in the structure and function of the cardiovascular system between men and women (32). Several studies have shown that premenopausal women are protected from most cardiovascular events as compared with men (26). However, after the menopause, women are at an increased risk of cardiovascular complications as compared with premenopausal women (26). The pathophysiological mechanisms for such differences are not clear, but studies have shown that sex steroids make some contribution (30,36,42).Trauma is often seen in civilian and military situations. Hemorrhage and hemorrhagic shock are the major causes of early deaths in injured soldiers and in injuries due to accidents. Studies have shown that traumatic hemorrhagic shock accounts for Ϸ50% of deaths of battle personnel and for 66%-80% of trauma deaths (8, 13). Vascular responsiveness is a key factor in maintaining vascular tone and hemodynamic stability, helps to determine tissue perfusion, and affects other organ functions (23,24). ...

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Section: Discussionmentioning

confidence: 99%

Section: Animal Studiesmentioning

confidence: 99%

Section: Animal Studiesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Age and sex differences in vascular responsiveness in healthy and trauma patients: contribution of estrogen receptor-mediated Rho kinase and PKC pathways

Xiao

Zhang

et al. 2014

American Journal of Physiology-Heart and Circulatory Physiology

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Advances in Early Treatment of Combat and Traumatic Shock

Liu

2016

Advanced Trauma and Surgery

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Resuscitation after hemorrhagic shock: the effect on the liver—a review of experimental data

et al. 2012

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The liver is currently considered to be one of the first organs to be subjected to the hypoxic insult inflicted by hemorrhagic shock. The oxidative injury caused by resuscitation also targets the liver and can lead to malfunction and the eventual failure of this organ. Each of the various fluids, vasoactive drugs, and pharmacologic substances used for resuscitation has its own distinct effect(s) on the liver, and the anesthetic agents used during surgical resuscitation also have an impact on hepatocytes. The aim of our study was to identify the specific effect of these substances on the liver. To this end, we conducted a literature search of MEDLINE for all types of articles published in English, with a focus on articles published in the last 12 years. Our search terms were "hemorrhagic shock," "liver," "resuscitation," "vasopressors," and "anesthesia." Experimental studies form the majority of articles found in bibliographic databases. The effect of a specific resuscitation agent on the liver is assessed mainly by measuring apoptotic pathway regulators and inflammation-induced indicators. Apart from a wide range of pharmacological substances, modifications of Ringer's Lactate, colloids, and pyruvate provide protection to the liver after hemorrhage and resuscitation. In this setting, it is of paramount importance that the treating physician recognize those agents that may attenuate liver injury and avoid using those which inflict additional damage.

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A Small Dose of Arginine Vasopressin in Combination with Norepinephrine is a Good Early Treatment for Uncontrolled Hemorrhagic Shock After Hemostasis

Cited by 24 publications

References 23 publications

Age and sex differences in vascular responsiveness in healthy and trauma patients: contribution of estrogen receptor-mediated Rho kinase and PKC pathways

Age and sex differences in vascular responsiveness in healthy and trauma patients: contribution of estrogen receptor-mediated Rho kinase and PKC pathways

Advances in Early Treatment of Combat and Traumatic Shock

Resuscitation after hemorrhagic shock: the effect on the liver—a review of experimental data

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