A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

Li, Xiao Ling; Tang, Wei; Das, Sudipto; Muys, Bruna Rodrigues; Jones, Michael R.; Lazar, Sarah B.; Dangelmaier, Emily A.; Hartford, Corrine Corrina R; Grammatikakis, Ioannis; Hao, Qinyu; Sun, Qinyu; Schetter, Aaron J.; Martindale, Jennifer L.; Tang, Binwu; Jenkins, Lisa M. Miller; Robles, Ana I.; Walker, Robert L.; Ambs, Stefan; Chari, Raj; Shabalina, Svetlana A.; Gorospe, Myriam; Hussain, Perwez; Harris, Curtis C.; Meltzer, Paul S.; Prasanth, Kannanganattu V.; Aladjem, Mirit I.; Andrésson, Þorkell; Lal, Ashish

doi:10.7554/elife.53734

Cited by 58 publications

(23 citation statements)

References 61 publications

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“…FORCP is an ER-localized protein with two predicted transmembrane domains. Upon ER stress, FORCP inhibits basal proliferation and induces apoptosis [104]. However, the molecular mechanisms by which PIGBOS or FORCP regulates apoptosis in response to stress are unknown.…”

Section: Small Proteins Involved In Stress Response and Metabolic Reg...mentioning

confidence: 99%

The largely unexplored biology of small proteins in pro‐ and eukaryotes

Steinberg

Koch

2021

The FEBS Journal

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The large abundance of small open reading frames (smORFs) in prokaryotic and eukaryotic genomes and the plethora of smORF-encoded small proteins became only apparent with the constant advancements in bioinformatics, genomic, proteomic and biochemical tools.Small proteins are typically defined as proteins of less than 50 amino acids in prokaryotes and of less than 100 amino acids in eukaryotes and their importance for cell physiology and cellular adaptation is only beginning to emerge. In contrast to antimicrobial peptides, which are secreted by prokaryotic and eukaryotic cells for combatting pathogens and competitors, small proteins act within the producing cell mainly by stabilizing protein assemblies and by modifying the activity of larger proteins. Production of small proteins is frequently linked to stress conditions or environmental changes and therefore cells seem to use small proteins as intracellular modifiers for adjusting cell metabolism to different intra-and extracellular cues. However, the size of small proteins imposes a major challenge for the cellular machinery required for protein folding and intracellular trafficking and recent data indicate that small proteins can engage distinct trafficking pathways. In the current review, we describe the diversity of small proteins in prokaryotes and eukaryotes, highlight distinct and common features and illustrate how they are handled by the protein trafficking machineries in prokaryotic and eukaryotic cells. Finally, we also discuss future topics of research on this fascinating but largely unexplored group of proteins.

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Section: Small Proteins Involved In Stress Response and Metabolic Reg...mentioning

confidence: 99%

The largely unexplored biology of small proteins in pro‐ and eukaryotes

Steinberg

Koch

2021

The FEBS Journal

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“…The FORCP transcript was not detected in most cell types, but was abundant in well-differentiated colorectal cancer cells, suggesting that FORCP is a novel small conserved protein encoded by misannotated lncRNA. FORCP can inhibit cell proliferation, clone formation and tumorigenesis ( 69 ).…”

Section: Lncrna Encoded Small Peptidesmentioning

confidence: 99%

Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer

et al. 2021

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Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer.

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“…LncRNAs play various roles in biological processes, including splicing, 48 protein localization, 49 and cellular proliferation. 50,51 LncRNAs are highly cell type specific in their expression patterns which makes them attractive as disease biomarkers for. 52 This is something that could be a particularly attractive area of investigation for autoinflammatory conditions such as arthritis and SLE which are notoriously difficult to diagnose quickly in the clinic.…”

Section: Ln Crna S and Innate Immunit Ymentioning

confidence: 99%

What sequencing technologies can teach us about innate immunity*

Salih

Carpenter

2021

Immunological Reviews

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For years, we have taken a reductionist approach to understanding gene regulation through the study of one gene in one cell at a time. While this approach has been fruitful it is laborious and fails to provide a global picture of what is occurring in complex situations involving tightly coordinated immune responses. The emergence of wholegenome techniques provides a system-level view of a response and can provide a plethora of information on events occurring in a cell from gene expression changes to splicing changes and chemical modifications. As with any technology, this often results in more questions than answers, but this wealth of knowledge is providing us with an unprecedented view of what occurs inside our cells during an immune response. In this review, we will discuss the current RNA-sequencing technologies and what they are helping us learn about the innate immune system.

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A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

Cited by 58 publications

References 61 publications

The largely unexplored biology of small proteins in pro‐ and eukaryotes

The largely unexplored biology of small proteins in pro‐ and eukaryotes

Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer

What sequencing technologies can teach us about innate immunity*

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