A smart upconversion-based light-triggered polymer for synergetic chemo-photodynamic therapy and dual-modal MR/UCL imaging

Du, Bin; Han, Song‐De; Zhao, Feifei; Lim, Kok Hwa; Xi, Hongwei; Su, Xiangjie; Yao, Hanchun; Zhou, Jie

doi:10.1016/j.nano.2016.05.004

Cited by 23 publications

(17 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diagnosis is a prerequisite for treatment. Among available diagnostic modalities such as computed tomography, positron emission tomography, fluorescence imaging, and magnetic resonance imaging, ultrasound imaging has comparative advantages over others including being noninvasive and providing real‐time imaging . Furthermore, US imaging is a convenient and inexpensive solution for patients .…”

Section: Introductionmentioning

confidence: 99%

A Smart Responsive Dual Aptamers‐Targeted Bubble‐Generating Nanosystem for Cancer Triplex Therapy and Ultrasound Imaging

Zhao

Zhou

et al. 2017

Small

Self Cite

View full text Add to dashboard Cite

The absence of targeted, single treatment methods produces low therapeutic value for treating cancers. To increase the accumulation of drugs in tumors and improve the treatment effectiveness, near-infrared 808 nm photothermal responsive dual aptamers-targeted docetaxel (DTX)-containing nanoparticles is proposed. In this system, DTX and NH HCO are loaded in thermosensitive liposomes. The surface of liposomes is coated with gold nanoshells and connected with sulfydryl (SH) modified AS1411 and S2.2 aptamers. The nanosystem has good biocompatibility and uniform size (diameter about 200 nm). The drug is rapidly released, reaching a maximum amount (84%) at 4 h under 808 nm laser irradiation. The experiments conducted in vitro and in vivo demonstrate the nanosystem can synergistically inhibit tumor growth by combination of chemotherapy, photothermal therapy, and biological therapy. Dual ligand functionalization significantly increases cellular uptake on breast cancer cell line (MCF-7) cells and achieves ultrasound imaging (USI) at tumor site. The results indicate that this drug delivery system is a promising theranostic agent involving light-thermal response at tumor sites, dual ligand targeted triplex therapy, and USI.

show abstract

Section: Introductionmentioning

confidence: 99%

A Smart Responsive Dual Aptamers‐Targeted Bubble‐Generating Nanosystem for Cancer Triplex Therapy and Ultrasound Imaging

Zhao

Zhou

et al. 2017

Small

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently UCNPs have been utilized as nanocarriers for photosensitizer in PDT . UCNPs have been integrated with photosensitizers including merocyanine, docetaxel, zinc phthalocyanine, chlorin e6, doxorubicin (Figure ), and pyropheophorbide a to develop PDT. The resultant conjugates exhibit efficient singlet oxygen generation after NIR light exposure giving an improved therapeutic effect, both in vitro and in vivo.…”

Section: Photosensitizers (Ps)mentioning

confidence: 99%

“…[57] UCNPs have been found to be chemically stable and unlike organic fluorescent dyes,U CNPs avoid traditional photobleaching complications.Recently UCNPs have been utilized as nanocarriers for photosensitizer in PDT. [58] UCNPs have been integrated with photosensitizers including merocyanine, [59] docetaxel, [60] zinc phthalocyanine, [61] chlorin e6, [56b] doxorubicin ( Figure 5), [62] and pyropheophorbide a [34] to develop PDT.T he resultant conjugates exhibit efficient singlet oxygen generation after NIR light exposure giving an improved therapeutic effect, both in vitro and in vivo. Furthermore,s ome groups [56b] prepared nanorattles made of ah ydrophilic rare-earth doped NaYF 4 shell and magnetic nanoparticle cores.T his material showed excellent water dispersion capability,ah igh drug-loading capacity,a nd low cytotoxicity;i twas also shown to be useful for cell imaging.…”

Section: Upconversion Nanoparticles (Ucnps)mentioning

confidence: 99%

Enhancement of Photodynamic Cancer Therapy by Physical and Chemical Factors

2019

View full text Add to dashboard Cite

The viable use of photodynamic therapy (PDT) in cancer therapy has never been fully realized because of its undesirable effects on healthy tissues. Herein we summarize some physicochemical factors that can make PDT a more viable and effective option to provide future oncological patients with better‐quality treatment options. These physicochemical factors include light sources, photosensitizer (PS) carriers, microwaves, electric fields, magnetic fields, and ultrasound. This Review is meant to provide current information pertaining to PDT use, including a discussion of in vitro and in vivo studies. Emphasis is placed on the physicochemical factors and their potential benefits in overcoming the difficulty in transitioning PDT into the medical field. Many advanced techniques, such as employing X‐rays as a light source, using nanoparticle‐loaded stem cells and bacteriophage bio‐nanowires as a photosensitizer carrier, as well as integration with immunotherapy, are among the future directions.

show abstract

“…Vork urzem wurden UCNPs als Nanoträger fürP hotosensibilisatoren in der PDT verwendet. [58] Fürd ie Entwicklung von PDT-Anwendungen wurden UCNPs mit Photosensibilisatoren wie Merocyanin, [59] Docetaxel, [60] Zinkphthalocyanin, [61] Chlor [51] Angewandte Chemie Aufsätze e6, [56b] Doxorubicin (Abbildung 5) [62] und Pyropheophorbid [34] [68] So kçnnen PS-XLNP-Komplexe direkt im Tu mor durch den effektiven Energietransfer von den angeregten XLNP zum Photosensibilisator aktiviert werden. Der grçßte Vorteil der Verwendung von Rçntgenstrahlung ist deren Fähigkeit, tief in das Gewebe einzudringen und somit tiefe Tumore behandelbar zu machen.…”

Section: Upconversion-nanopartikel (Ucnps)unclassified

Optimierung photodynamischer Krebstherapien auf der Grundlage physikalisch‐chemischer Faktoren

Yang

Mao

2019

Angewandte Chemie

View full text Add to dashboard Cite

Der Einsatz der photodynamischen Therapie (PDT) in der Krebstherapie ist aufgrund der unerwünschten Auswirkungen auf das gesunde Gewebe nie vollständig realisiert worden. Wir fassen hier einige physikalisch‐chemische Faktoren zusammen, die PDT zu einer tragfähigeren und effektiveren Methode machen, um zukünftigen Krebspatienten qualitativ bessere Behandlungsmöglichkeiten bieten zu können. Diese physikalisch‐chemischen Faktoren umfassen Lichtquellen, Träger für Photosensibilisatoren (PS), Mikrowellen, elektrische Felder, Magnetfelder und Ultraschall. Wir diskutieren aktuelle Ergebnisse zur Anwendung der PDT, einschließlich In‐vitro‐ und In‐vivo‐Studien und mit einem Schwerpunkt auf den physikalisch‐chemischen Faktoren der PDT. Eine Vielzahl von fortschrittlichen Techniken, wie z. B. der Einsatz von Röntgenstrahlung als Lichtquelle, die Nutzung von Nanopartikel‐beladenen Stammzellen und bakteriophagen Bionanodrähten als Photosensibilisatorträger sowie die Integration mit der Immuntherapie, sind Teil der Entwicklung des Gebiets.

show abstract

A smart upconversion-based light-triggered polymer for synergetic chemo-photodynamic therapy and dual-modal MR/UCL imaging

Cited by 23 publications

References 41 publications

A Smart Responsive Dual Aptamers‐Targeted Bubble‐Generating Nanosystem for Cancer Triplex Therapy and Ultrasound Imaging

A Smart Responsive Dual Aptamers‐Targeted Bubble‐Generating Nanosystem for Cancer Triplex Therapy and Ultrasound Imaging

Enhancement of Photodynamic Cancer Therapy by Physical and Chemical Factors

Optimierung photodynamischer Krebstherapien auf der Grundlage physikalisch‐chemischer Faktoren

Contact Info

Product

Resources

About