Drug addiction is one of the most important issues in developing countries and it has become a serious issue, which has impacted social health, significantly. In this paper, we study the relationship between age, gender and residential status with drug addiction. The study chooses a sample of 900 people where 450 were female, 450 were male, and all the residence lived in province of Esfahan, Iran. In our survey, two third of the surveyed people were living in cities and only one third of the surveyed people were residing in rural areas. The results of our survey have indicated that there were some positive relationship between age and addiction to drugs and between gender and addiction to drugs (Sig=0.04). In other words, older people will more likely to go for drug addiction. In addition, men tend to get addicted more than women do (Sig=0.03). However, there is no evidence to believe that residential status had any impact on addiction to drugs.