A soil-inspired dynamically responsive chemical system for microbial modulation

Lin, Yiliang; Gao, Xiang; Yue, Jiping; Fang, Yan; Shi, Jiuyun; Meng, Lingyuan; Clayton, Clementene; Zhang, Xin‐Xing; Shi, Fengyuan; Deng, Junjing; Chen, Si; Jiang, Yi; Marin, Fabricio; Hu, Jingtian; Tsai, Hsiu‐Ming; Tu, Qing; Roth, Eric W.; Bleher, Reiner; Chen, Xinqi; Griffin, Philip J.; Cai, Zhonghou; Promiński, Aleksander; Odom, Teri W.; Tian, Bozhi

doi:10.1038/s41557-022-01064-2

Cited by 22 publications

(26 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, the introduction of inorganic materials into living matter can modulate the behaviors of biological cells and tissues through optical, electrical, or thermal stimulation. 112,113 Nanomaterials can also impart biological systems with novel augmented functions beyond evolution, such as conductivity, luminescence, light absorption, resistance, or therapy. [114][115][116][117][118] The techniques from synthetic biology and materials science have greatly contributed to the design of functional amyloids, endowing them with diverse activities both in vitro and in vivo.…”

Section: Design Strategies For Functional Amyloid Fibrillar Assembliesmentioning

confidence: 99%

Section: Design Strategies For Functional Amyloid Fibrillar Assembliesmentioning

confidence: 99%

See 1 more Smart Citation

Rational design of functional amyloid fibrillar assemblies

Wang

Zhang

et al. 2023

Chem. Soc. Rev.

View full text Add to dashboard Cite

show abstract

Section: Design Strategies For Functional Amyloid Fibrillar Assembliesmentioning

confidence: 99%

Section: Design Strategies For Functional Amyloid Fibrillar Assembliesmentioning

confidence: 99%

Rational design of functional amyloid fibrillar assemblies

Wang

Zhang

et al. 2023

Chem. Soc. Rev.

View full text Add to dashboard Cite

show abstract

“…The interaction between microbiota and their colonized environments is critical for biogeochemical cycles, ecological resilience, and human health . Inspired by the microbially colonized nature of soil, our group designed a chemical system that could serve as a responsive platform for the modulation of microbial systems (Figure a) . The system comprises nanoclay, starch granules, and liquid-metal particles.…”

Section: Microscale Colloid-based Materials For Biointerfacesmentioning

confidence: 99%

Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications

Li,

Huberman-Shlaes,

Tian

2023

Langmuir

Self Cite

View full text Add to dashboard Cite

Colloid-based materials with tunable biophysical and chemical properties have demonstrated significant potential in a wide range of biomedical applications. The ability to manipulate these properties across various size scales, encompassing nano-, micro-, and macrodomains, is essential to enhancing current biomedical technologies and facilitating the development of novel applications. Focusing on material design, we explore various synthetic colloid-based materials at the nano- and microscales and investigate their correlation with biological systems. Furthermore, we examine the utilization of the self-assembly of colloids to construct monolithic and macroscopic materials suitable for biointerfaces. By probing the potential of spatial imaging and localized drug delivery, enhanced functionality, and colloidal manipulation, we highlight emerging opportunities that could significantly advance the field of colloid-based materials in biomedical applications.

show abstract

“…[17][18][19] In light of the fact, the dynamic gradients of nutrients and metabolites in the intestinal tract enable bacteria with distinct metabolic characteristics to find appropriate colonized environments. [20][21][22][23][24][25] Therefore, we synthesized a gradient hydrogel with multilayer structure, allowing substances to form a concentration gradient to maintain the survival of bacteria with different metabolic requirements (Figure 1a). [26][27][28] Encapsulated intestinal bacteria spontaneously form engineered microbiota (EM) highly similar to intestinal microbiota.…”

Section: Introductionmentioning

confidence: 99%

A Microbial Community Cultured in Gradient Hydrogel for Investigating Gut Microbiome‐Drug Interaction and Guiding Therapeutic Decisions

Zheng

Qiao

et al. 2023

Advanced Materials

View full text Add to dashboard Cite

Despite the recognition that the gut microbiota acts a clinically significant role in cancer chemotherapy, both mechanistic understanding and translational research are still limited. Maximizing drug efficacy requires an in-depth understanding of how the microbiota contributes to therapeutic responses, while microbiota modulation is hindered by the complexity of the human body. To address this issue, a 3D experimental model named engineered microbiota (EM) is reported for bridging microbiota-drug interaction research and therapeutic decision-making. EM can be manipulated in vitro and faithfully recapitulate the human gut microbiota at the genus/species level while allowing co-culture with cells, organoids, and isolated tissues for testing drug responses. Examination of various clinical and experimental drugs by EM reveales that the gut microbiota affects drug efficacy through three pathways: immunological effects, bioaccumulation, and drug metabolism. Guided by discovered mechanisms, custom-tailored strategies are adopted to maximize the therapeutic efficacy of drugs on orthotopic tumor models with patient-derived gut microbiota. These strategies include immune synergy, nanoparticle encapsulation, and host-guest complex formation, respectively. Given the important role of the gut microbiota in influencing drug efficacy, EM will likely become an indispensable tool to guide drug translation and clinical decision-making.

show abstract

A soil-inspired dynamically responsive chemical system for microbial modulation

Cited by 22 publications

References 70 publications

Rational design of functional amyloid fibrillar assemblies

Rational design of functional amyloid fibrillar assemblies

Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications

A Microbial Community Cultured in Gradient Hydrogel for Investigating Gut Microbiome‐Drug Interaction and Guiding Therapeutic Decisions

Contact Info

Product

Resources

About