A solid-state electrochemiluminescence composite modified electrode based on Ru(bpy)32+/PAHNSA: Characterization and pharmaceutical applications

Al-Hinaai, Mohammed M.; Khudaish, Emad A.; Al-Harthy, Salim; Suliman, Fakhr Eldin O.

doi:10.1016/j.electacta.2015.06.148

Cited by 11 publications

(3 citation statements)

References 42 publications

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“…The ECL response of Ru (bpy) 3 2+ can be significantly enhanced in the presence of a co-reactant. Therefore, it is also possible to construct a signal-on ECL mode to detect co-reactants of Ru (bpy) 3 2+ ( Liu and Zhou, 2006 ; Al-Hinaai et al, 2015 ). As a proof-of-concept demonstration, chlorpheniramine (CPM), which is one of the most effective antihistamines for the treatment of allergic and vasomotor rhinitis, allergic conjunctivitis, mild urticaria, angioedema, and anaphylactic shock, was detected by the VMSF/APTES/3DG sensor.…”

Section: Resultsmentioning

confidence: 99%

Vertically Ordered Mesoporous Silica-Nanochannel Film-Equipped Three-Dimensional Macroporous Graphene as Sensitive Electrochemiluminescence Platform

et al. 2021

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Three-dimensional (3D) electrochemiluminescence (ECL) platform with high sensitivity and good anti-fouling is highly desirable for direct and sensitive analysis of complex samples. Herein, a novel ECL-sensing platform is demonstrated based on the equipment of vertically ordered mesoporous silica-nanochannel films (VMSF) on monolithic and macroporous 3D graphene (3DG). Through electrografting of 3-aminopropyltriethoxysilane (APTES) onto 3DG as molecular glue, VMSF grown by electrochemically assisted self-assembly (EASA) method fully covers 3DG surface and displays high stability. The developed VMSF/APTES/3DG sensor exhibits highly sensitized ECL response of tris(2,2′-bipyridyl) ruthenium (Ru (bpy)32+) taking advantages of the unique characteristics of 3DG (high active area and conductivity) and VMSF nanochannels (strong electrostatic enrichment). The VMSF/APTES/3DG sensor is applied to sensitively detect an important environmental pollutant (4-chlorophenol, with limit of detection or LOD of 30.3 nM) in term of its quenching effect (ECL signal-off mode) toward ECL of Ru (bpy)32+/tri-n-propylamine (TPrA). The VMSF/APTES/3DG sensor can also sensitively detect the most effective antihistamines chlorpheniramine (with LOD of 430 nM) using ECL signal-on mode because it acts as co-reactant to promote the ECL of Ru (bpy)32+. Combined with the excellent antifouling ability of VMSF, the sensor can also realize the analysis of actual environmental (lake water) and pharmaceutical (pharmacy tablet) samples. The proposed 3D ECL sensor may open new avenues to develop highly sensitive ECL-sensing platform.

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Section: Resultsmentioning

confidence: 99%

Vertically Ordered Mesoporous Silica-Nanochannel Film-Equipped Three-Dimensional Macroporous Graphene as Sensitive Electrochemiluminescence Platform

et al. 2021

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“…The flow-cell chamber for ECL experiments was made of Plexiglas materials (manufactured by FIA lab Instruments, Bellevue, WA, USA), mimicking the basic design of CC-5 flow cell (BAS, West Lafayette, USA) described in our previous work. 6 A connected syringe pump (FIAlab Instruments, Medina, WA, USA) controls the flow rate of various eluted fluids inside the flow-cell. The entire cell system, Fabrication and surface characterization.-A comprehensive discussion and elucidation of various steps involved in the construction of the proposed solid-state ECL sensor were described in our previous work.…”

Section: Methodsmentioning

confidence: 99%

“…4,5 Immobilization of the luminescent molecule (or its derivatives) onto the electrode surface was one important task for manufacturing solid-state ECL sensors with high sensitivity and stability. [6][7][8][9] Various studies focus on fabrication of polymeric modified electrodes doped with luminescent molecules via electrostatic interactions or covalent bond formation to enhance their reactivity and stability. [10][11][12] Incorporation of luminescent molecules into polymeric films compromise metallopolymeric interfaces characterized by the mutual communication between the π-conjugated backbones and redox couple of ruthenium central (Ru 3+/2+ ) ions.…”

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confidence: 99%

Electrochemiluminescence Quantification of Amine Functionalized Drugs at Ru(bpy)₃²⁺/poly(4-amino-diphenylamine) Sensor Incorporated with AuNPs: Potential Analysis of Ephedrine

Al-Hinaai

Rather

Khudaish

2018

J. Electrochem. Soc.

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An electrochemiluminescence (ECL) sensor based on a sandwich gold nanoparticles (AuNPs) linkage species amid luminescence molecules, [Ru(bpy) 3 ] 2+ , doped at a pre-alkaline poly(4-aminodiphenylamine), t-Padpa, film has been employed for the quantification of some tertiary amines including buspirone (BUS), triprolidine (TPL), diphenhydramine (DPH) and chlorpheniramine (CPM). The proposed sensor (Ru.AuNPs.Ru.t-Padpa/GCE) showed high sensitivity and good stability with limit of detection (LOD) low enough for successful application and determination of above drugs in their pharmaceutical formulation. The relationship between the observed ECL intensity and the structural attribute of these drugs was justified by the type of attached nitrogen functionalities, the presence of electron donating or electron withdrawing groups and the extent of anodic potential. The potential analysis of ephedrine (EPH), a secondary amine, proceeded by in-situ derivatization reaction with formaldehyde to produce a strongly ECL susceptible aminol intermediate. Variation of EPH concentration at constant amount of formaldehyde significantly enhances ECL signals and drops the LOD of EPH into 1.2 ng/mL. Real sample analysis of EPH was satisfactorily recovered regardless of drug matrixes and presence of interference species. The protocol of sensor construction along with the reductive addition reaction confirms that the present ECL approach meets the highest demand required for EPH analysis.

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Tris(2,2’-bipyridyl)ruthenium (II) complex as a universal reagent for the fabrication of heterogeneous electrochemiluminescence platforms and its recent analytical applications

et al. 2023

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A solid-state electrochemiluminescence composite modified electrode based on Ru(bpy)32+/PAHNSA: Characterization and pharmaceutical applications

Cited by 11 publications

References 42 publications

Vertically Ordered Mesoporous Silica-Nanochannel Film-Equipped Three-Dimensional Macroporous Graphene as Sensitive Electrochemiluminescence Platform

Vertically Ordered Mesoporous Silica-Nanochannel Film-Equipped Three-Dimensional Macroporous Graphene as Sensitive Electrochemiluminescence Platform

Electrochemiluminescence Quantification of Amine Functionalized Drugs at Ru(bpy)₃²⁺/poly(4-amino-diphenylamine) Sensor Incorporated with AuNPs: Potential Analysis of Ephedrine

Tris(2,2’-bipyridyl)ruthenium (II) complex as a universal reagent for the fabrication of heterogeneous electrochemiluminescence platforms and its recent analytical applications

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A solid-state electrochemiluminescence composite modified electrode based on Ru(bpy)32+/PAHNSA: Characterization and pharmaceutical applications

Cited by 11 publications

References 42 publications

Vertically Ordered Mesoporous Silica-Nanochannel Film-Equipped Three-Dimensional Macroporous Graphene as Sensitive Electrochemiluminescence Platform

Vertically Ordered Mesoporous Silica-Nanochannel Film-Equipped Three-Dimensional Macroporous Graphene as Sensitive Electrochemiluminescence Platform

Electrochemiluminescence Quantification of Amine Functionalized Drugs at Ru(bpy)32+/poly(4-amino-diphenylamine) Sensor Incorporated with AuNPs: Potential Analysis of Ephedrine

Tris(2,2’-bipyridyl)ruthenium (II) complex as a universal reagent for the fabrication of heterogeneous electrochemiluminescence platforms and its recent analytical applications

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Electrochemiluminescence Quantification of Amine Functionalized Drugs at Ru(bpy)₃²⁺/poly(4-amino-diphenylamine) Sensor Incorporated with AuNPs: Potential Analysis of Ephedrine