This paper presents a groundbreaking numerical technique for solving nonlinear time fractional differential equations, combining the conformable continuity equation (CCE) with the Non-Polynomial Spline (NPS) interpolation to address complex mathematical challenges. By employing conformable descriptions of fractional derivatives within the CCE framework, our method ensures enhanced accuracy and robustness when dealing with fractional order equations. To validate our approach’s applicability and effectiveness, we conduct a comprehensive set of numerical examples and assess stability using the Fourier method. The proposed technique demonstrates unconditional stability within specific parameter ranges, ensuring reliable performance across diverse scenarios. The convergence order analysis reveals its efficiency in handling complex mathematical models. Graphical comparisons with analytical solutions substantiate the accuracy and efficacy of our approach, establishing it as a powerful tool for solving nonlinear time-fractional differential equations. We further demonstrate its broad applicability by testing it on the Burgers–Fisher equations and comparing it with existing approaches, highlighting its superiority in biology, ecology, physics, and other fields. Moreover, meticulous evaluations of accuracy and efficiency using (L2 and L∞) norm errors reinforce its robustness and suitability for real-world applications. In conclusion, this paper presents a novel numerical technique for nonlinear time fractional differential equations, with the CCE and NPS methods’ unique combination driving its effectiveness and broad applicability in computational mathematics, scientific research, and engineering endeavors.