2009
DOI: 10.1038/nature08074
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A spatial gradient coordinates cell size and mitotic entry in fission yeast

Abstract: Many eukaryotic cell types undergo size-dependent cell cycle transitions controlled by the ubiquitous cyclin-dependent kinase Cdk1 (refs 1-4). The proteins that control Cdk1 activity are well described but their links with mechanisms monitoring cell size remain elusive. In the fission yeast Schizosaccharomyces pombe, cells enter mitosis and divide at a defined and reproducible size owing to the regulated activity of Cdk1 (refs 2, 3). Here we show that the cell polarity protein kinase Pom1, which localizes to c… Show more

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Cited by 343 publications
(675 citation statements)
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“…In fact, Cdr2 is the protein that reads the positional information generated by Pom1 gradient [Martin and Berthelot-Grosjean, 2009;Moseley et al, 2009]: in cells lacking Pom1, Cdr2 spreads toward the nongrowing tip; Mid1 distribution follows that of Cdr2, which results in mispositioned septa, closer to the nongrowing cell tips. In agreement with the role of Cdr2 in transducing Pom1 positional information to Mid1, Cdr2 deletion partially rescues the division plane position defects of pom1D cells despite the presence of morphological defects in the double deletion mutant [Lee and Wu, 2012].…”
Section: Cdr2 Serves As a Receptor For Mid1 And Reads The Positional mentioning
confidence: 99%
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“…In fact, Cdr2 is the protein that reads the positional information generated by Pom1 gradient [Martin and Berthelot-Grosjean, 2009;Moseley et al, 2009]: in cells lacking Pom1, Cdr2 spreads toward the nongrowing tip; Mid1 distribution follows that of Cdr2, which results in mispositioned septa, closer to the nongrowing cell tips. In agreement with the role of Cdr2 in transducing Pom1 positional information to Mid1, Cdr2 deletion partially rescues the division plane position defects of pom1D cells despite the presence of morphological defects in the double deletion mutant [Lee and Wu, 2012].…”
Section: Cdr2 Serves As a Receptor For Mid1 And Reads The Positional mentioning
confidence: 99%
“…Along the years, Pom1 has emerged as a critical factor regulating key processes such as polarized cell growth and cell division [Bahler and Nurse, 2001;Niccoli et al, 2003;Celton-Morizur et al, 2006;Padte et al, 2006;Tatebe et al, 2008;Martin and Berthelot-Grosjean, 2009;Moseley et al, 2009]. Pom1 localizes to the cell tip cortex where it forms a gradient which integrates spatial information on cell size and geometry, in a manner that depends indirectly on microtubules Tatebe et al, 2005].…”
Section: Cell Tips Inhibit Mid1 Cortical Localizationmentioning
confidence: 99%
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