A special device (double-hole belly board) and optimal radiation technique to reduce testicular radiation exposure in radiotherapy of rectal cancer

Vorwerk, Hilke; Hermann, Robert Michael; Christiansen, Hans; Liersch, T.; Hess, Clemens F.; Weiss, Elisabeth

doi:10.1016/j.radonc.2007.06.017

Cited by 12 publications

(6 citation statements)

References 13 publications

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“…This can be explained by using a dislocation device, which may cause the dislocation of the bladder within the radiation field. As demonstrated by Vorwerk et al, the irradiated bladder volume increases in 50% of the patients with the application of a belly board (41).…”

Section: Discussionmentioning

confidence: 87%

Capecitabine Initially Concomitant to Radiotherapy Then Perioperatively Administered in Locally Advanced Rectal Cancer

Zampino

Magni

Leonardi

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussionmentioning

confidence: 87%

Capecitabine Initially Concomitant to Radiotherapy Then Perioperatively Administered in Locally Advanced Rectal Cancer

Zampino

Magni

Leonardi

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…A conventional gonad shield based on the placement of a lead block on a shadow tray reduced the testicular dose by 27-41%. With the round gonad shield made of Estimation of scattered testicular radiation according to measurements on a anthropomorphic phantom during radiotherapy for rectal cancer and validation by in vivo scrotal dosimeters (case series) Dueland [10] 2003 25 Sex hormone levels in male rectal cancer patient during long-course radiochemotherapy (case series) Piroth [11] 2003 18 Measurement of scattered testicular radiation in 18 patients by scrotal dosimeters during long-course radiotherapy for rectal cancer (case series) Hermann [12] 2005 11 Measurement of scattered testicular dose and sex hormone levels in rectal cancer patients treated by long-course radiotherapy (case series) Mazonakis [13] 2006 5 Estimation of scattered testicular radiation according to measurements on a anthropomorphic phantom during radiotherapy for rectal cancer and validation by in vivo scrotal dosimeters (case series) Vorwerk [14] 2007 9…”

Section: Testicular Radiation Exposure During Radiotherapy For Rectalmentioning

confidence: 99%

Testicular Function After Radiotherapy for Rectal Cancer—A Review

Buchli

Arver

Holm

2011

The Journal of Sexual Medicine

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Introduction Eighty percent of all male rectal cancer patients are sexually active at the time of diagnosis. Because of modern multimodal therapy many can expect long-term survival. The testes can be exposed to scattered or direct radiation during radiotherapy, depending on their position in relation to the targeted volume. Aim This review analyzes the current literature providing data on testicular exposure to radiation during radiotherapy for rectal cancer and the consequences on testicular function. Methods A systematic search was conducted in PubMed, Embase, and Cochrane. Ten original articles providing data on testicular exposure to radiation and testicular function in men with primary rectal cancer were included for qualitative synthesis. Main Outcome Measures Data on testicular exposure to radiation and testosterone levels in men with rectal cancer are reported. Results On average, the testes were exposed to 0.24–8.4 Gy during long-course radiotherapy for rectal cancer. Testosterone levels after radiation were significantly lower compared with pretreatment levels or compared with patients treated with surgery alone. After radiotherapy, the absolute risk increase was 0.17–0.30 for posttreatment testosterone levels below 8 nmol/L. In the largest study, the relative risk was 2.7 for testosterone levels below 8 nmol/L for men treated with radiotherapy compared with men treated with surgery alone. Conclusion Current data generate three hypotheses: (i) during long-course radiotherapy for rectal cancer, the testes can be exposed to direct and/or scattered radiation; (ii) men treated with radiotherapy seem at risk to develop testicular dysfunction with decreased serum testosterone levels compared with both pretreatment values and men treated with surgery alone; and (iii) a decrease in testosterone levels (<8 nmol/L) may precipitate specific symptoms caused by testosterone deficiency such as impaired physical, psychological, and sexual function after treatment.

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“…1 week later, after resolution of mucosal swelling due to implantation procedure, the patients underwent a CT for treatment planning. Male patients were positioned prone on a double-hole belly board [24], female patients on a single-hole belly board. Continuous 5-mm CT scans of the treatment region in the pelvis were obtained with a spiral CT scanner (Somatom Balance, Siemens Medical Systems, Forchheim, Germany).…”

Section: Gold Markersmentioning

confidence: 99%

Gold markers for tumor localization and target volume delineation in radiotherapy for rectal cancer

Vorwerk¹,

Liersch

Rothe

et al. 2009

Strahlenther Onkol

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The use of gold marker enables a more precise definition of the target volume for radiotherapy in patients with rectal cancer. This could eventually allow a better protection of anal structures of patients with a tumor localization > or = 5 cm cranial of the anal sphincter. The implantation of the gold markers improved communication between the surgeon, the radiooncologist and the pathologist resulting in intensified exchange of relevant informations.

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A special device (double-hole belly board) and optimal radiation technique to reduce testicular radiation exposure in radiotherapy of rectal cancer

Cited by 12 publications

References 13 publications

Capecitabine Initially Concomitant to Radiotherapy Then Perioperatively Administered in Locally Advanced Rectal Cancer

Capecitabine Initially Concomitant to Radiotherapy Then Perioperatively Administered in Locally Advanced Rectal Cancer

Testicular Function After Radiotherapy for Rectal Cancer—A Review

Gold markers for tumor localization and target volume delineation in radiotherapy for rectal cancer

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