A special issue on cell signaling, disease, and stem cells

Li, Dangsheng

doi:10.1038/cr.2012.7

Cited by 10 publications

(3 citation statements)

References 18 publications

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“…In the mouse prostate, Pten haploinsufficiency cooperates with Rheb-overexpression and markedly promoted mTORC1-mediated prostate tumorigenesis [ 88 ] (Figure 3 ). Compelling evidence has recently demonstrated that mTORC1 controls the translational program of mRNA subsets of genes involved in PCa initiation, invasion and metastasis [ 89 - 91 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer

et al. 2012

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Prostate cancer (PCa) is dependent on androgen receptor signaling and aberrations of the PI3K-Akt-mTORC1 pathway mediating excessive and sustained growth signaling. The nutrient-sensitive kinase mTORC1 is upregulated in nearly 100% of advanced human PCas. Oncogenic mTORC1 signaling activates key subsets of mRNAs that cooperate in distinct steps of PCa initiation and progression. Epidemiological evidence points to increased dairy protein consumption as a major dietary risk factor for the development of PCa. mTORC1 is a master regulator of protein synthesis, lipid synthesis and autophagy pathways that couple nutrient sensing to cell growth and cancer. This review provides evidence that PCa initiation and progression are promoted by cow´s milk, but not human milk, stimulation of mTORC1 signaling. Mammalian milk is presented as an endocrine signaling system, which activates mTORC1, promotes cell growth and proliferation and suppresses autophagy. Naturally, milk-mediated mTORC1 signaling is restricted only to the postnatal growth phase of mammals. However, persistent consumption of cow´s milk proteins in humans provide highly insulinotropic branched-chain amino acids (BCAAs) provided by milk´s fast hydrolysable whey proteins, which elevate postprandial plasma insulin levels, and increase hepatic IGF-1 plasma concentrations by casein-derived amino acids. BCAAs, insulin and IGF-1 are pivotal activating signals of mTORC1. Increased cow´s milk protein-mediated mTORC1 signaling along with constant exposure to commercial cow´s milk estrogens derived from pregnant cows may explain the observed association between high dairy consumption and increased risk of PCa in Westernized societies. As well-balanced mTORC1-signaling plays an important role in appropriate prostate morphogenesis and differentiation, exaggerated mTORC1-signaling by high cow´s milk consumption predominantly during critical growth phases of prostate development and differentiation may exert long-term adverse effects on prostate health. Attenuation of mTORC1 signaling by contemporary Paleolithic diets and restriction of dairy protein intake, especially during mTORC1-dependent phases of prostate development and differentiation, may offer protection from the most common dairy-promoted cancer in men of Western societies.

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Section: Introductionmentioning

confidence: 99%

The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer

et al. 2012

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“…As a general interest life science journal, Cell Research has enjoyed a phase of rapid growth in the past several years, as shown by the dramatic improvement in the scientific quality of papers published in the journal as wells as its broadening impact within the scientific community. Along the way, the field of stem cell biology has naturally become an important research area covered by papers published in Cell Research [2]. For instance, in the past year of 2012, Cell Research has published a number of important papers related to the stem cell field, covering diverse aspects and topics such as induced pluripotent stem (iPS) cells [3][4][5][6][7], mechanistic studies of pluripotency and differentiation [8][9][10][11], modeling of human diseases using stem cell-based systems [6,12], direct reprogramming of somatic cells to other cell types without passing through an pluripotent intermediate [13][14][15][16], as well as neural crest stem cells [17] and cancer stem cells [18][19][20].…”

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confidence: 99%

The 2013 special issue on stem cell biology

2013

Cell Res

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“…Rice, like any other plant, adapts to these abiotic stresses and copes by using several signaling cascades at the cellular level (Vinocur & Altman, 2005). The basic units of life are cells and efficient cell signaling is required for functioning and development (Li, 2012). The cell signaling, critical for survival under stress via control and regulation of the current biochemical information from the external environment to inside of the cells, is achieved by the diverse signaling cascades operating at cellular and tissue levels in a plant.…”

Section: Introductionmentioning

confidence: 99%

Stacking for future: Pyramiding genes to improve drought and salinity tolerance in rice

Shailani

Joshi

Singla‐Pareek

et al. 2020

Physiologia Plantarum

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Abiotic stresses, such as drought and salinity, adversely affect rice production and cause a severe threat to food security. Conventional crop breeding techniques alone are inadequate for achieving drought stress tolerance in crop plants. Using transgenic technology, incremental improvements in tolerance to drought and salinity have been successfully attained via manipulation of gene(s) in several crop species. However, achieving the goal via pyramiding multiple genes from the same or different tolerance mechanisms has received little attention. Pyramiding of multiple genes can be achieved either through breeding, by using marker-assisted selection, or by genetic engineering through molecular stacking co-transformation or re-transformation. Transgene stacking into a single locus has added advantages over breeding or re-transformation since the former assures co-inheritance of genes, contributing to more effective tolerance in transgenic plants for generations. Drought, being a polygenic trait, the potential candidate genes for gene stacking are those contributing to cellular detoxification, osmolyte accumulation, antioxidant machinery, and signaling pathways. Since cellular dehydration is inbuilt in salinity stress, manipulation of these genes results in improving tolerance to salinity along with drought in most of the cases. In this review, attempts have been made to provide a critical assessment of transgenic plants developed through transgene stacking and approaches to achieve the same. Identification and functional validation of more such candidate genes is needed for research programs targeting the gene stacking for developing crop plants with high precision in the shortest possible time to ensure sustainable crop productivity under marginal lands. | INTRODUCTIONRice is a staple food crop consumed by nearly half of the human population. Asia alone contributes to 90% of the rice produced worldwide (Maclean et al., 2002). However, changing climatic conditions, biotic stress (such as fungi, bacteria, insects, viruses), and abiotic stress (including salinity, drought, submergence, extreme temperature, wounding, mineral deficiency, and oxidative stress) affect rice plants in many ways, ultimately contributing to reduction in crop yield (Akos et al., 2019;Kaya et al., 2020). Among these abiotic stresses, drought alone affects more than 50% of the rice production (23 million ha of rain-fed rice globally)

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A special issue on cell signaling, disease, and stem cells

Cited by 10 publications

References 18 publications

The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer

The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer

The 2013 special issue on stem cell biology

Stacking for future: Pyramiding genes to improve drought and salinity tolerance in rice

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