A spectrophotometric method for simultaneous estimation of phenytoin and carbamazepine

Jaffery, Nargis F.; Sn, Ahmad; Jailkhani, B. L.

doi:10.1016/0160-5402(83)90048-7

Cited by 10 publications

(3 citation statements)

References 7 publications

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“…A heteropoly blue procedure has been proposed for the simultaneous determination of the orthoand pyrophosphate anions (363). A number of spectrophotometric methods have been proposed for the simultaneous analysis of organic constituents and include methods for the simultaneous determination of aromatic compounds in middle distillate fuels (257), 4,4,-diaminodibenzyl and cis-4,4'-diaminostilbene (71), aspirin, phenacetin, and caffeine in their mixtures (589), 2,4-dinitroaniline and 2',4,4'-trinitrobenzanilide (342), orthoand paraisomers of nitrophenylsuccinic acid (481), deoxy-, carboxy-, oxy-, sulfhemoglobins, and hemiglobin, as well as oxygen saturation (609,613), ethosuximide, phenytoin, and phenobarbital (214); and phenytoin and carbamazepine (231).…”

Section: Chemistrymentioning

confidence: 99%

Ultraviolet and light absorption spectrometry

Hargis¹,

Howell²

1984

Anal. Chem.

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Section: Chemistrymentioning

confidence: 99%

Ultraviolet and light absorption spectrometry

Hargis¹,

Howell²

1984

Anal. Chem.

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“…Various methods have been reported for the determination of CBZ in pharmaceutical preparations including spectrophotometric methods [4][5][6][7][8], spectrofluorimetry method [9], gas-liquid chromatography (GC) [10,11], FT-Raman spectroscopy [12], planar chromatography [13], and high performance liquid chromatography (HPLC) [14][15][16][17][18][19][20][21][22][23][24]. Most of the methods reported are highly sophisticated, costly, and time consuming and require special sample preparation.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of HPTLC Method for Estimation of Carbamazepine in Formulations and Its In Vitro Release Study

Patel

Bhatt

et al. 2011

Chromatography Research International

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A new, simple, and rapid high-performance thin-layer chromatographic method was developed and validated for quantitative determination of Carbamazepine. Carbamazepine was chromatographed on silica gel 60F254TLC plate using ethyl acetate-toluene-methanol (5.0 + 4.0 + 1.0 v/v/v) as mobile phase. Carbamazepine was quantified by densitometric analysis at 285 nm. The method was found to give compact spots for the drug (Rf=0.47 ± 0.01). The linear regression analysis data for the calibration plots showed good linear relationship withr2=.9995in the concentration range 100–600 ng/spot. The method was validated for precision, recovery, repeatability, and robustness as per the International Conference on Harmonization guidelines. The minimum detectable amount was found to be 16.7 ng/spot, whereas the limit of quantitation was found to be 50.44 ng/spot. Statistical analysis of the data showed that the method is precise, accurate, reproducible, and selective for the analysis of Carbamazepine. The method was successfully employed for the estimation of equilibrium solubility, quantification of Carbamazepine as a bulk drug, in commercially available preparation, and in-house developed mucoadhesive microemulsion formulations and solution.

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“…However, few simple and inexpensive direct spectrophotometric methods with good sensitivity and selectivity have been reported for the determination of phenytoin [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%