We report point-contact measurements of anisotropic magnetoresistance (AMR) in a single crystal of antiferromagnetic Mott insulator Sr 2 IrO 4 . The point-contact technique is used here as a local probe of magnetotransport properties on the nanoscale. The measurements at liquid nitrogen temperature reveal negative magnetoresistances (up to 28%) for modest magnetic fields (250 mT) applied within the IrO 2 a-b plane and electric currents flowing perpendicular to the plane. The angular dependence of magnetoresistance shows a crossover from fourfold to twofold symmetry in response to an increasing magnetic field with angular variations in resistance from 1% to 14%. We tentatively attribute the fourfold symmetry to the crystalline component of AMR and the field-induced transition to the effects of applied field on the canting of antiferromagnetic-coupled moments in Sr 2 IrO 4 . The observed AMR is very large compared to the crystalline AMRs in 3d transition metal alloys or oxides (0.1%-0.5%) and can be associated with the large spin-orbit interactions in this 5d oxide while the transition provides evidence of correlations between electronic transport, magnetic order, and orbital states. The finding of this work opens an entirely new avenue to not only gain a new insight into physics associated with spin-orbit coupling but also to better harness the power of spintronics in a more technically favorable fashion. [13] behaviors, which makes them an attractive playground for studying physics driven by spin-orbit interactions. As AMR is known to be closely associated with spin-orbit interaction, the strong spin-orbit interaction in this 5d transition metal oxide may favor stronger AMR compared to 3d transition metal alloys and oxides. The recent magnetotransport studies in Sr 2 IrO 4 single crystals [14,15] and thin films [6] revealed largely unexplored correlations between electronic transport, magnetic order, and orbital states.Here, we present the first observation of the pointcontact AMR in single crystals of the AFM Mott insulator Sr 2 IrO 4 [14-16], which can potentially be used to sense the AFM order parameter in spintronic nanodevices. The pointcontact technique allows us to probe very small volumes and, therefore, measures electronic transport on a microscopic scale. Point-contact measurements with single crystals of Sr 2 IrO 4 are intended to examine whether the additional local resistance associated with a small contact area between a sharpened Cu tip and the antiferromagnet shows a magnetoresistance (MR) like that seen in bulk crystals. The measurements at liquid nitrogen temperature reveal large MRs (up to 28%) for modest magnetic fields (250 mT) applied within the IrO 2 a-b plane. The angular dependence of MR reveals an AMR with an intriguing transition from fourfold to twofold symmetry in response to