A Split-Face Comparison Study of Pulsed 532-nm KTP Laser and 595-nm Pulsed Dye Laser in the Treatment of Facial Telangiectasias and Diffuse Telangiectatic Facial Erythema

Uebelhoer, Nathan S.; Bogle, Melissa A.; Stewart, Brigitte; Arndt, Kenneth A.; Dover, Jeffrey S.

doi:10.1111/j.1524-4725.2007.33091.x

Cited by 44 publications

(46 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We went on to validate the assay in pigs receiving influenza vaccines in order to determine its clinical potential. A clinical, long pulse 595 nm laser was used to illuminate the site of HA-MN array application because of its common use in humans [28]. The power used in clinic was 7.5~20 J/cm 2 and we thus tried the energy downward as we had no intention to rupture any vessels.…”

Section: Resultsmentioning

confidence: 99%

Sample-free quantification of blood biomarkers via laser-treated skin

Wang

Yang

et al. 2015

Biomaterials

View full text Add to dashboard Cite

Surface modified microneedle (MN) arrays are being developed to capture circulating biomarkers from the skin, but inefficiency and unreliability of the current method limit its clinical applications. We describe here that illumination of a tiny area of the skin with hemoglobin-preferably absorbent laser increased the amount of circulating biomarkers in the upper dermis by more than 1,000-fold. The hemoglobin-specific light altered the permeability of capillaries leading to extravasation of molecules but not blood cells beneath the skin involved. When specific probe-coated MN arrays were applied into the laser-treated skin, the biomarkers accumulated in the upper dermis were reliably, accurately, and sufficiently captured as early as 15 min of the assay. The maximal binding occurred in one hr in a manner independent of penetration depth or a molecular mass of the biomarker. With anti-fluorescein isothiocyanate (FITC)-MNs, we were able to measure blood concentrations of FITC in mice receiving FITC intravenously. The sensitivity and accuracy were comparable to those attained by fluorescence spectrophotometer. Likewise, MNs containing influenza hemagglutinin (HA) could detect anti-HA antibody in mice or swine receiving influenza vaccines as effectively as standard immunoassays. The novel, minimally invasive approach holds great promise for measurement of multiple biomarkers by a single array for point-of-care diagnosis.

show abstract

Section: Resultsmentioning

confidence: 99%

Sample-free quantification of blood biomarkers via laser-treated skin

Wang

Yang

et al. 2015

Biomaterials

View full text Add to dashboard Cite

show abstract

“…However, KTP laser was not as successful as lpNd:YAG laser in removing macular erythema and inflammatory rosacea lesions. In previous studies, controversial results have been reported concerning the comparative clinical efficacy of KTP and other vascular lasers; e.g., PDL (18)(19)(20)(21)(22). KTP laser has also been reported to be very safe when used in combination with topical retinaldehyde (21).…”

Section: Discussionmentioning

confidence: 99%

The Comparison of the Efficacy and Safety of Q-Switched Potassium Titanyl Phosphate Laser and Long-Pulsed Neodymium-Doped Yttrium Aluminum Garnet Laser in the Treatment of Erythematotelangiectatic and Papulopustular Rosacea

Üstüner¹,

Balevi²,

Özdemır³

2018

tdd

View full text Add to dashboard Cite

Objective: The best laser for patients with erythematotelangiectatic rosacea is still a controversial topic. The efficacy and safety of Q-switched potassium titanyl phosphate (KTP) and long-pulsed neodymium-doped yttrium aluminum garnet (lpNd:YAG) lasers were compared in the treatment of erythematotelangiectatic and papulopustular rosacea. Methods: Thirty patients aged 16-70 years who had multiple telangiectasias on both sides of the face and a diagnosis of stage 1-2 rosacea were included in a split-face, double-blinded, randomized clinical trial. Lasers were applied to two different sides of the face for four sessions at one-month intervals. The number of papules and pustules were investigated before treatment and at each visit. The erythematotelangiectatic rosacea severity scores, thickness of telangiectasias, clinician's assessment of treatment response, patient satisfaction, and adverse effects were examined. Results: In the third and fourth months, the number of papules on the side treated with lpNd:YAG laser was significantly lower than the other side. In the fourth month, the mild or severe erythematotelangiectatic rosacea score rate was significantly lower on the side treated with lpNd:YAG laser. The clinician's assessment was similar for both treatments. Conclusion: We recommend lpNd:YAG laser for erythema and Q-switched KTP laser for thin and superficial telangiectasias for the highest treatment efficacy. Keywords: Erythema, lasers, purpura, rosacea, solid-state, telangiectasias Amaç: Eritemotelenjiektatik rozasealı hastalar için en iyi lazer halen tartışmalı bir konudur. Q-anahtarlı potassium titanyl phosphate (KTP) ve uzun atımlı neodymium-doped yttrium aluminum garnet (lpNd:YAG) lazerlerin eritemotelenjiektatik ve papülopüstüler rozasea tedavisinde etkinliği ve güvenilirliği karşılaştırıldı. Yöntemler: Yüzünün her iki yanında çok sayıda telenjiektazileri olan ve evre 1-2 rozasea tanısı bulunan 16-70 yaşları arasında 30 hasta yarım-yüz, çift-kör, randomize klinik çalışmaya alındı. Lazerler yüzün iki farklı yanına bir aylık aralıklarla 4 seans uygulandı. Tedavi öncesinde ve her takipte papül ve püstül sayısı araştırıldı. Eritemotelenjiektatik rozasea şiddet skoru, telenjiektazi kalınlığı, klinisyenin tedavi yanıtını değerlendirmesi, hasta memnuniyeti ve yan etkiler incelendi. Öz

show abstract

“…In the study of Uebelhoer et al [30], 15 patients with facial telangiectasias were treated using a PDL on one side of the face and a KTP laser on the other. While both lasers were highly effective in the treatment of facial telangiectasia and redness, the KTP laser was more effective but led to more postoperative swelling and erythema.…”

Section: Discussionmentioning

confidence: 99%

“…Many therapeutic modalities, especially laser systems [16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36] or intense pulsed light (IPL) [18,19,20] have been applied in the treatment of these telangiectasias. The aim of this study was to present a single-institution experience of treating extranasal telangiectasias by means of Nd:YAG laser.…”

Section: Introductionmentioning

confidence: 99%

Nd:YAG Laser Treatment for Extranasal Telangiectasias: A Retrospective Analysis of 38 Patients with Hereditary Hemorrhagic Telangiectasia and Review of the Literature

Papaspyrou

Schick²,

Kadah³

2016

ORL

View full text Add to dashboard Cite

Background/Aims: Extranasal telangiectasiasare common amongsthereditary hemorrhagic telangiectasia (HHT) patients. Telangiectasias can be found at sites like the external nose, lips, oral cavity and fingers. Although not life threatening, they can be annoying for patients and lead to bleeding in some cases, necessitating treatment. Methods: The data of 38 HHT patients treated for extranasal telangiectasias during a period of 10 years by means of Nd:YAG laser were retrospectively analyzed. Results: The telangiectasias treated affected predominantly the tongue, facial skin and lips. During a minimum follow-up of 3 years, only 7 patients required a revision of surgery. Conclusion: This study shows that Nd:YAG laser constitutes a fast, safe and efficient therapeutic modality for the treatment of extranasal telangiectasias.

show abstract

A Split-Face Comparison Study of Pulsed 532-nm KTP Laser and 595-nm Pulsed Dye Laser in the Treatment of Facial Telangiectasias and Diffuse Telangiectatic Facial Erythema

Abstract: Both the 595-nm and the 532-nm pulsed lasers are highly effective in the treatment of facial telangiectasia and redness. The 532-nm KTP laser appears to be more effective but causes more swelling and erythema.

Cited by 44 publications

References 18 publications

Sample-free quantification of blood biomarkers via laser-treated skin

Sample-free quantification of blood biomarkers via laser-treated skin

The Comparison of the Efficacy and Safety of Q-Switched Potassium Titanyl Phosphate Laser and Long-Pulsed Neodymium-Doped Yttrium Aluminum Garnet Laser in the Treatment of Erythematotelangiectatic and Papulopustular Rosacea

Nd:YAG Laser Treatment for Extranasal Telangiectasias: A Retrospective Analysis of 38 Patients with Hereditary Hemorrhagic Telangiectasia and Review of the Literature

Contact Info

Product

Resources

About