Current Aspects in Pharmaceutical Research and Development Vol. 4 2021
DOI: 10.9734/bpi/caprd/v4/2869e
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A Stability Indicating Reverse Phase High Performance Liquid Chromatography Method for Simultaneous Estimation of Hydroquinone, Hydrocortisone and Tretenoin in Cream Formulation: A Recent Study

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“…In one study, researchers have shown 37 % degradation of hydrocortisone succinate (Solu-Cortef®) solution for injection or infusion after 24 h of storage at 60 • C (Mihovec et al, 2022). Other studies have demonstrated similar findings, the findings regarding the impurities cannot be compared to our own findings due to differences in the analytical method (Genete et al, 2012;Shilu et al, 2021;Saira and Sadia, 2020;Zhang et al, 2016). Not much is known regarding the toxicity of the several degradation products found in the these studies.…”
Section: Discussionmentioning
confidence: 82%
“…In one study, researchers have shown 37 % degradation of hydrocortisone succinate (Solu-Cortef®) solution for injection or infusion after 24 h of storage at 60 • C (Mihovec et al, 2022). Other studies have demonstrated similar findings, the findings regarding the impurities cannot be compared to our own findings due to differences in the analytical method (Genete et al, 2012;Shilu et al, 2021;Saira and Sadia, 2020;Zhang et al, 2016). Not much is known regarding the toxicity of the several degradation products found in the these studies.…”
Section: Discussionmentioning
confidence: 82%