A standardized methanol extract of Eclipta prostrata (L.) L. (Asteraceae) reduces bronchial hyperresponsiveness and production of Th2 cytokines in a murine model of asthma

Morel, Lucas Junqueira de Freitas; Azevedo, Bruna Cestari de; Carmona, Fábio; Contini, Sílvia Helena Taleb; Teles, Aristônio Magalhães; Ramalho, Fernando Silva; Bertoni, Bianca Waléria; França, Suzelei de Castro; Borges, Marcos C.; Pereira, Ana Maria Soares

doi:10.1016/j.jep.2016.12.008

Cited by 43 publications

(14 citation statements)

References 42 publications

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“…Only 1 reference presented a model of asthma as an allergic inflammatory condition, where the species Eclipta prostrata was decreased bronchial hyperresponsiveness [50].…”

Section: Comparison Between Methods Used For Pharmacological Evaluatimentioning

confidence: 99%

“…Carrageenan-induced paw edema [132] Croton oil-induced ear edema [132] Peritonitis induced by lipopolysaccharide [132] Pleurisy induced by carrageenan [89] Model of induced arthritis [65] Model of induced asthma [50] Induced mucositis [37] Wound healing assay [102] Formalin test (inflammatory phase) [93] Psoriasis treatment (clinical trial) [36] Percentage ( The search for more classic pharmaceutical forms, such as drug solutions, found ethanolic or aqueous extracts, among others, of Smallanthus sonchifolius for direct application as topical use, for example, in ear edema as described by Oliveira et al [88]. Among the assayed extracts, the extract obtained by rinsing the leaves with acetone presented the highest percentage of ear edema inhibition (44 %) when applied in mice induced by croton oil.…”

Section: In Vitromentioning

confidence: 99%

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Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Lopes

Oliveira²,

Viçosa³

et al. 2020

Planta Med

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Compositae is the largest family of flowering plants, with more than 1600 genera and 22 000 species. It has many economic uses in foods, cosmetics, and pharmaceutics. The literature reports its numerous medicinal benefits and recognized anti-inflammatory activity. Thus, this study evaluated the technological trends of anti-inflammatory activity of Compositae, based on the survey of scientific databases, articles, and patents, as well as the website of the Brazilian National Health Regulatory Agency (ANVISA), which is responsible for registering and controlling of healthcare and cosmetic products in the Brazil. The survey was conducted between 2008 and 2018, in the databases Science Direct, Lilacs, PubMed, and Web of Science (main collection), as well as the SciELO Citation Index. The patent survey was carried out on the basis of the Derwent Innovations Index, an important source for worldwide patent consultation, which covers 20 y of registered patents. Despite the numerous studies involving species of the Compositae family in different models of anti-inflammatory activity, there are few records of patents or products on the market from these species for that purpose. Some species have a traditional use and are present even in the Phytotherapic Summary of the Brazilian Pharmacopeia. This review confirms the therapeutic potential of Compositae for the development of anti-inflammatory drugs and reinforces the need to develop competencies and reduce technological bottlenecks to promote research and innovation in biodiversity products.

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“…Only 1 reference presented a model of asthma as an allergic inflammatory condition, where the species Eclipta prostrata was decreased bronchial hyperresponsiveness [50].…”

Section: Comparison Between Methods Used For Pharmacological Evaluatimentioning

confidence: 99%

Section: In Vitromentioning

confidence: 99%

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Lopes

Oliveira²,

Viçosa³

et al. 2020

Planta Med

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“…It is used in the treatment of spleen enlargements, uterine hemorrhages, skin diseases, scorpion bites and respiratory disorders (Pithayanukul et al 2004;Khare, 2007). This plant has been experimentally proven to possesses nephroprotective, cerebroprotective, hepato-protective, anti-cancer, anti-asthma, mosquito larvicidal and ovicidal properties, toxicity against hepatitis-C virus, hair growth promoting activity, immunemodulatory property, antioxidant, lipid lowering activity and anti-venom property (Dungca, 2016;Chaudhary et al 2011;de Freitas Morel et al 2017;Jayathirtha and Mishra, 2004;Datta et al 2009;Govindarajan and Karuppannan, 2011). Presence of wedelolactone, ecliptamines, taraxastane glycosides, polythienyl and other phytochemicals has been reported in this plant (Zhang et al 2010;Liu et al 2012;Han et al 2013).…”

Section: Introductionmentioning

confidence: 94%

Development of Chemical Fingerprints to Differentiate the Controversial Indian Herbal Drugs Eclipta Prostrata and Wedelia Calendulacea (Bhringraja)

Vadivel¹,

Anand²,

Monajkumar³

et al. 2017

Bull. Pharm. Res.

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In Indian system of medicine, Eclipta prostrata is an important herbal ingredient of several Ayurvedic and Siddha formulations and it is commonly called as Bhringraja. But, this plant is often confused with Wedelia calendulacea, which is also known as Bhringraja and also being adulterated in Indian herbal market. In order to differentiate these plant drugs (Eclipta prostrata and Wedelia calendulacea), in the present work we have developed chemical fingerprints. Phytochemical analysis, UV-Visible, FT-IR and NMR spectroscopy, HPTLC and HPLC chromatography were carried out in the selected plant materials. Phytochemical analysis of methanolic extract of investigated materials showed that W. calendulacea contained higher level of total phenolic compounds (381.82 mg GAE/100 g) when compared to E. prostrata (105 mg GAE/100 g). Scanning in UV-Visible spectroscopy exhibited difference between selected samples, especially at 250-450 nm. Similarly, FT-IR spectroscopy of raw materials indicated notable difference between the samples at 400 -1000 cm -1 region. NMR spectroscopy illustrated remarkable difference between the chloroform extract of selected samples at 1-2 ppm region. HPTLC profile of methanolic extract of E. prostrata exhibited a total number of 9 peaks while W. calendulacea showed 12 number of peaks. Chemical profile investigated in the present study would be helpful to differentiate E. prostrata from W. calendulacea and also useful to prevent their adulteration in herbal industry.

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“…These outcomes show that EP can enhance colitis manifestations through the adjustment of invulnerable capacity in intestinal epithelial cells and recommends that EP has the potential restorative impact to intestinal aggravation. [15] Morel LJF et alhave been reported Eclipta prostrata (L.) L. (Asteraceae) has been utilized in Brazilian customary prescription to treat asthma and other respiratory ailments. [16] Ding S et al have been reported Tobacco smoke is the main source of the improvement of different lung maladies including lung disease through activating oxidant push and provocative reactions which added to the sores of ordinary human bronchial epithelial (NHBE) cell.…”

Section: Anti Inflammatory Activitymentioning

confidence: 99%

A brief lightening on medicinal activity and Pharmacological profile of plant Eclipta prostrata: A Review

Kumar¹,

Singh²

2019

IJCTR

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The aim of this studyfocused on the pharmacological profile of the plant Eclipta prostrata. these activities are wound recuperating, antihyperglycaemic, Alopecia, Hepatoprotective, gum disease, Immunomodulator, cancer prevention agent, hostile to diabetic, antidote venom, Osteoprotective, antidermatophytic, antibacterial, hostile to HIV, anticancer, cytotoxic and so forth. EcliptaProstrata is little expanded yearly herbaceous plant with an antiquated time conventional drugs utilizes in numerous nations particularly in tropical and subtropical districts. An assortment of synthetic aggravate that are available in various parts of plant including coumestans, alkaloids, thiopenes, flavonoids, polyacetylenes, triterpenes and their glycosides have been confined from this species. This commitment gives a complete survey on pharmacological profile as therapeutic plant.

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A standardized methanol extract of Eclipta prostrata (L.) L. (Asteraceae) reduces bronchial hyperresponsiveness and production of Th2 cytokines in a murine model of asthma

Abstract: The results presented herein demonstrate for the first time the anti-inflammatory activity of E. prostrata in a murine model of asthma, thereby supporting the ethnopharmacological uses of the plant.

Cited by 43 publications

References 42 publications

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Development of Chemical Fingerprints to Differentiate the Controversial Indian Herbal Drugs Eclipta Prostrata and Wedelia Calendulacea (Bhringraja)

A brief lightening on medicinal activity and Pharmacological profile of plant Eclipta prostrata: A Review

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