A stimuli-responsive insulin delivery system based on reversible phenylboronate modified cyclodextrin with glucose triggered host-guest interaction

Xu, Xinyuan; Shang, Hui; Zhang, Tianyu; Shu, Peixian; Liu, Yanpeng; Xie, Jing; Zhang, Dongyue; Tan, Hong; Li, Jianshu

doi:10.1016/j.ijpharm.2018.07.020

Cited by 23 publications

(11 citation statements)

References 28 publications

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“…However, the regular injections not only compromise the patient's quality of life but also fail to precisely maintain the optimum dose of insulin, leading to chronic complications of diabetes. It is desirable to develop an improved treatment for diabetes that meets the patient's physiological and lifestyle requirements [1][2][3]. One possible route to developing an improved treatment is based on the use of polymeric nanogels.…”

Section: Introductionmentioning

confidence: 99%

Dextran-crosslinked glucose responsive nanogels with a self-regulated insulin release at physiological conditions

Elshaarani

Lin

et al. 2020

European Polymer Journal

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Section: Introductionmentioning

confidence: 99%

Dextran-crosslinked glucose responsive nanogels with a self-regulated insulin release at physiological conditions

Elshaarani

Lin

et al. 2020

European Polymer Journal

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“…-CD, a cyclic oligosaccharide with abundant hydroxylcontaining functional groups, is commonly used to form inclusion complexes with various hydrophobic drugs which can improve their pharmaceutical properties. [13][14][15] In this work, -CD/g-C 3 N 4 nanocomplex was prepared via a grafting method. An ultrahigh drug-loading capacity and a pH-responsive drug release were simultaneously achieved.…”

mentioning

confidence: 99%

β‐cyclodextrin modified g‐C₃N₄ nanosheet: a fluorescent drug carrier with ultrahigh drug loading capacity and pH‐responsive release

Liu

Dong

Zeng

et al. 2018

J of Chemical Tech & Biotech

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Background β‐cyclodextrin modified g‐C3N4 (β‐CD/g‐C3N4) nanosheets were successfully synthesized and developed as a novel drug carrier of doxorubicin hydrochloride (DOX•HCl). The prepared samples were characterized by Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD) and transmission electron microscopy (TEM). The drug‐loading and drug release was measured by a UV–visible spectrophotometer. Moreover, cell viability tests were carried out to evaluate the inhibition ratio of β‐CD/g‐C3N4‐DOX•HCl and bulk g‐C3N4‐DOX•HCl. Results The FTIR result confirmed that β‐CD and g‐C3N4 are linked by hydrogen bonds. The XRD and TEM results showed that β‐CD/g‐C3N4 has nanosheet structure with size range 150–300 nm. The drug‐loading ratio rises sharply in the first 14 h and reaches a maximum of 93%. Moreover, β‐CD/g‐C3N4 nanocomplex showed a pH‐responsive DOX•HCl release with a release ratio of 80% at pH = 5, which is two times higher than that of bulk g‐C3N4. Cell viability tests demonstrated that the β‐CD/g‐C3N4‐DOX•HCl exhibit a higher inhibition ratio on MG63 cells than bulk g‐C3N4‐DOX•HCl. Conclusion β‐CD/g‐C3N4 nanocomplex achieves an ultrahigh drug‐loading capacity and pH‐responsive release and visualization of the cell phagocytic process. The results indicate that the β‐CD/g‐C3N4 nanocomplex can be developed as a promising luminescence carrier for drug delivery. © 2018 Society of Chemical Industry

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“…The broad vibration band at 3392 cm −1 belongs to O–H stretching vibration, which also arises in the spectra of the pure β-CD sample. These results clearly indicate the formation of β-CD-CN [ 30 ].…”

Section: Resultsmentioning

confidence: 93%

A β-cyclodextrin Modified Graphitic Carbon Nitride with Au Co-Catalyst for Efficient Photocatalytic Hydrogen Peroxide Production

et al. 2020

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Photocatalytic hydrogen peroxide (H2O2) production has attracted considerable attention as a renewable and environment-friendly method to replace other traditional production techniques. The performance of H2O2 production remains limited by the inertness of graphitic carbon nitride (CN) towards the adsorption and activation of O2. In this work, a photocatalyst comprising of β-cyclodextrin (β-CD)-modified CN with supporting Au co-catalyst (Au/β-CD-CN) has been utilized for effective H2O2 production under visible light irradiation. The static contact angle measurement suggested that β-CD modification increased the hydrophobicity of the CN photocatalyst as well as its affinity to oxygen gas, leading to an increase in H2O2 production. The rate of H2O2 production reached more than 0.1 mM/h under visible-light irradiation. The electron spin resonance spectra indicated that H2O2 was directly formed via a 2-electron oxygen reduction reaction (ORR) over the Au/β-CD-CN photocatalyst.

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A stimuli-responsive insulin delivery system based on reversible phenylboronate modified cyclodextrin with glucose triggered host-guest interaction

Cited by 23 publications

References 28 publications

Dextran-crosslinked glucose responsive nanogels with a self-regulated insulin release at physiological conditions

Dextran-crosslinked glucose responsive nanogels with a self-regulated insulin release at physiological conditions

β‐cyclodextrin modified g‐C₃N₄ nanosheet: a fluorescent drug carrier with ultrahigh drug loading capacity and pH‐responsive release

A β-cyclodextrin Modified Graphitic Carbon Nitride with Au Co-Catalyst for Efficient Photocatalytic Hydrogen Peroxide Production

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A stimuli-responsive insulin delivery system based on reversible phenylboronate modified cyclodextrin with glucose triggered host-guest interaction

Cited by 23 publications

References 28 publications

Dextran-crosslinked glucose responsive nanogels with a self-regulated insulin release at physiological conditions

Dextran-crosslinked glucose responsive nanogels with a self-regulated insulin release at physiological conditions

β‐cyclodextrin modified g‐C3N4 nanosheet: a fluorescent drug carrier with ultrahigh drug loading capacity and pH‐responsive release

A β-cyclodextrin Modified Graphitic Carbon Nitride with Au Co-Catalyst for Efficient Photocatalytic Hydrogen Peroxide Production

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Product

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β‐cyclodextrin modified g‐C₃N₄ nanosheet: a fluorescent drug carrier with ultrahigh drug loading capacity and pH‐responsive release