A strategy for ZnO nanorod mediated multi-mode cancer treatment

Zhang, Haijun; Chen, Baoan; Jiang, Hui; Wang, Cailian; Wang, Huangping; Wang, Xuemei

doi:10.1016/j.biomaterials.2010.11.027

Cited by 291 publications

(183 citation statements)

References 21 publications

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“…fluid decontamination, and cell sorting. Zinc oxide nanoparticles are metal oxides with a wide range of applications and possess unique optical, chemical sensing, antibacterial [46,47], electrical conductivity, and piezoelectric properties [48]. In addition, research results have shown that TiO2 [49] and ZrO2 [50] nanoparticles enhance the strength and conductivity of supported substrates.…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Min¹,

Koh²

2018

Preprint

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In the field of tissue engineering, conductive hydrogels have been the most effective biomaterials to mimic the biological and electrical properties of tissues in the human body. The main advantages of conductive hydrogel include not only its physical properties, but also its adequate electrical properties, thus providing electrical signals to cells efficiently. However, when introducing a conductive material into a non-conductive hydrogel, a conflicting relationship between the electrical and mechanical properties may develop. This review examines the strengths and weaknesses of the generation of conductive hydrogels using various conductive materials and introduces the use of these conductive hydrogels in tissue engineering applications.

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Section: Metal Nanoparticlesmentioning

confidence: 99%

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Min¹,

Koh²

2018

Preprint

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“…9 Thus, we were inspired to construct a Dox-ZnO nanocomplex as a prospective multimodal agent for integrated diverse anticancer therapeutics, which offers a promising opportunity for combining Dox chemotherapy and PDT using ZnO, for synergistic therapeutic effects. As a follow-up to the study of ZnO nanomaterial-mediated multimode cancer treatment we reported previously, 10 in this study, we further explored the specific possible molecular mechanisms involved.…”

Section: Introductionmentioning

confidence: 98%

The synergistic effect and mechanism of doxorubicin-ZnO nanocomplexes as a multimodal agent integrating diverse anticancer therapeutics

Deng¹,

Zhang²

2013

IJN

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Background: Nanomaterials have emerged as ideal multimodal nanomedicine platforms, each one combining different designs and therapeutic approaches in a single system against cancer. The aim of the current study was to explore the synergistic effect and mechanism of a doxorubicin (Dox)-ZnO nanocomplex as a multimodal drug delivery system, integrating Dox chemotherapy and ZnO-mediated photodynamic therapy, in anticancer therapeutics. Methods: Dox was loaded onto ZnO nanomaterials, forming complexes with the transition metal Zn to yield the Dox-ZnO nanocomplexes. After culture with SMMC-7721 hepatocarcinoma cells, the cellular uptake was quantitatively detected by flow cytometry and visualized by fluorescence microscopy. The synergistic effects of the different anticancer therapeutic modalities on the proliferation of SMMC-7721 hepatocarcinoma cells were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The expression of B-cell lymphoma 2 protein (Bcl-2), Bcl-2 associated X protein (Bax), caspase 9, and caspase 3 were examined by Western blot, to elucidate the possible molecular mechanisms involved. Results: Our observations demonstrated that Dox-ZnO nanocomplexes could act as an efficient drug delivery system for importing Dox into SMMC-7721 cells, enhancing its potential chemotherapy efficiency by increasing the intracellular concentration of Dox. With the addition of ultraviolet (UV) illumination, the ZnO nanomaterials showed excellent photodynamic therapeutic properties, attacking the cancer cells further. Thus the caspase-dependent apoptosis was synergistically induced, resulting in distinct improvement in anticancer activity. Conclusion: The Dox-ZnO nanocomplex presents a promising multimodal agent for comprehensive cancer treatment.

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“…It should be noted in the context of the undertaken research efforts that ZnO exhibits a whole range of promising properties, which can be utilized in optoelectronic applications (Chen et al, 2009), in sensors (Ates et al, 2013;Minh et al, 2013;Yin et al, 2014), light conversion (Baek et al, 2012;Nayeri et al, 2013), and drug delivery (Zhang et al, 2011). It decomposes dissolved organic impurities under UV irradiation (Colmenares et al, 2015) and exhibits antibacterial effects (Hossain et al, 2014), in particular in the case of E.coli and S.aureus (Jaisai et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Polypropylene – zinc oxide nanorod hybrid material for applications in separation processes

Jakubiak¹,

Tomaszewska²,

Jackiewicz³

et al. 2016

Chemical and Process Engineering

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Hybrid filter material was obtained via modification of polypropylene (PP) nonwoven with nanosize zinc oxide particles of a high aspect ratio. Modification was conducted as a three-step process, a variant of hydrothermal method used for synthesis of nano-ZnO, adopted for coating three dimensional polymeric nonwoven filters. The process consisted of plasma treatment of nonwoven to increase its wettability, deposition of ZnO nanoparticles and low temperature hydrothermal growth of ZnO rods. The modified nonwovens were investigated by a high resolution scanning electron microscopy (HR-SEM). It has been found that the obtained hybrid filters offer a higher filtration efficiency, in particular for so called most penetrating particle sizes.

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A strategy for ZnO nanorod mediated multi-mode cancer treatment

Cited by 291 publications

References 21 publications

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

The synergistic effect and mechanism of doxorubicin-ZnO nanocomplexes as a multimodal agent integrating diverse anticancer therapeutics

Polypropylene – zinc oxide nanorod hybrid material for applications in separation processes

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