A stress-dependent SUMO4 sumoylation of its substrate proteins

Wei, William; Yang, Ping; Pang, Junfeng; Zhang, Shu; Wang, Ying; Wang, Mong-Heng; Zheng, Dong; She, Jin‐Xiong; Wang, Cong Yi

doi:10.1016/j.bbrc.2008.08.028

Cited by 65 publications

(43 citation statements)

References 22 publications

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“…Under physiological conditions, SUMO1 is constitutively conjugated to substrates, while all other SUMO paralogs are preferentially conjugated in response to stress (42,45,48).…”

Section: Sumo Proteinsmentioning

confidence: 99%

SUMO conjugation – a mechanistic view

Pichler

Fatouros

Lee

et al. 2017

Biomolecular Concepts

218

223

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Abstract:The regulation of protein fate by modification with the small ubiquitin-related modifier (SUMO) plays an essential and crucial role in most cellular pathways. Sumoylation is highly dynamic due to the opposing activities of SUMO conjugation and SUMO deconjugation. SUMO conjugation is performed by the hierarchical action of E1, E2 and E3 enzymes, while its deconjugation involves SUMO-specific proteases. In this review, we summarize and compare the mechanistic principles of how SUMO gets conjugated to its substrate. We focus on the interplay of the E1, E2 and E3 enzymes and discuss how specificity could be achieved given the limited number of conjugating enzymes and the thousands of substrates.

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“…Under physiological conditions, SUMO1 is constitutively conjugated to substrates, while all other SUMO paralogs are preferentially conjugated in response to stress (42,45,48).…”

Section: Sumo Proteinsmentioning

confidence: 99%

SUMO conjugation – a mechanistic view

Pichler

Fatouros

Lee

et al. 2017

Biomolecular Concepts

218

223

View full text Add to dashboard Cite

show abstract

“…10 The physiological role of SUMO4, which is absent in most cell types and cannot be conjugated because of the lack of C-terminal processing (see below), is still under debate. [11][12][13] Genetic and biochemical data indicate that the 3 SUMO variants SUMO 1, 2, and 3 are likely to play partially redundant roles, although distinct effects in cellular processes have been described. 10,14,15 All SUMOs are expressed as precursor proteins and have to be processed before conjugation.…”

mentioning

confidence: 99%

The Ubiquitin-Like SUMO System and Heart Function

Mendler

Braun

Müller

2016

Circulation Research

101

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“…The conjugation of SUMO2/3 to substrates is usually induced when the cells are subjected to protein-damaging stimuli, such as acute temperature fluctuation, suggesting a role for SUMO2/3 in the cellular responses to environmental stress [11]. Covalent conjugation of SUMO4 to substrates is still under debate [13,14]. Finally, for some substrates, strong paralog preferences have been reported.…”

Section: Introductionmentioning

confidence: 99%

Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish

et al. 2009

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The Small ubiquitin-related modifier (SUMO) conjugation to a variety of proteins regulates diverse cellular processes, including transcription, cell cycle regulation and maintenance of genome integrity. To investigate in vivo biological function of SUMO paralogs, we inactivated them in the early development of zebrafish. While zebrafish embryos deficient for all three SUMO paralogs, as Ubc9-deficient ones, displayed severe defects, loss of individual SUMO paralog was compatible with a normal development. SUMO-deficient embryos can be rescued by a single human or zebrafish SUMO. While key structural basic lysine residues and N-terminal unstructured stretch of SUMO are critical for in vivo rescue, the consensus K11 sumoylation site of SUMO2 is dispensable, implying that chain formation on this potential site is unessential for normal development. Inactivation of all three SUMOs triggered p53-dependent apoptosis and further inactivation of p53 restored normal zebrafish development. Interestingly, we also demonstrate that the dominant negative truncated form of p53, Δ113p53, significantly blunts SUMO depletion-induced p53 activity in vivo. Taken together, our results suggest that SUMO paralogs are indispensable, but redundant, in the early development of zebrafish.

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A stress-dependent SUMO4 sumoylation of its substrate proteins

Cited by 65 publications

References 22 publications

SUMO conjugation – a mechanistic view

SUMO conjugation – a mechanistic view

The Ubiquitin-Like SUMO System and Heart Function

Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish

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