A Strong Positive Dendritic Effect in a Peptide Dendrimer-Catalyzed Ester Hydrolysis Reaction

Delort, Estelle; Darbre, Tamis; Reymond, Jean‐Louis

doi:10.1021/ja044652p

Cited by 151 publications

(98 citation statements)

References 13 publications

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“…One example for this application is the work done by Reimond et al [163][164][165][166]. They have identified a set of peptide-based dendrimers, firstly made from His-Ser and diaminopropionic acid (Dap) as branching units.…”

Section: Dendrimersmentioning

confidence: 99%

Peptide-Based Polymer Therapeutics

2014

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Abstract:Polypeptides are envisaged to achieve a major impact on a number of different relevant areas such as biomedicine and biotechnology. Acquired knowledge and the increasing interest on amino acids, peptides and proteins is establishing a large panel of these biopolymers whose physical, chemical and biological properties are ruled by their controlled sequences and composition. Polymer therapeutics has helped to establish these polypeptide-based constructs as polymeric nanomedicines for different applications, such as disease treatment and diagnostics. Herein, we provide an overview of the advantages of these systems and the main methodologies for their synthesis, highlighting the different polypeptide architectures and the current research towards clinical applications.

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Section: Dendrimersmentioning

confidence: 99%

Peptide-Based Polymer Therapeutics

2014

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“…The ability to tune the properties of dendrimers [1][2][3][4][5] has allowed their development for use in diverse applications, including drug delivery, [6][7][8][9][10][11][12][13][14][15] biomimicry, 8,9,[16][17][18][19] catalysis, 15,[20][21][22][23][24][25][26] organic light emitting diodes, 15,21,[27][28][29] molecular wires, 30,31 sensors, [32][33][34][35] imaging agents, 7,9 and various other utilities. 15,[36][37][38][39][40][41][42] Coincident with these developments is the increasing nee...…”

Section: Introductionmentioning

confidence: 99%

Dendrimers Clicked Together Divergently

et al. 2005

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Dendrimers containing 1,4-triazole linkages between each generation were grown divergently via the Click chemistry inspired Huisgen 1,3-dipolar cycloaddition reaction in the presence of a Cu(I) catalyst. The monomeric unit (1-propargylbenzene-3,5-dimethanol) contained the alkyne functionality, while the core (1,2-bis(2-azidoethoxy)ethane) and growing dendrimers presented the azide groups necessary for this type of Click reaction. The first generation dendrimer was also functionalized with alkyne termini to demonstrate an alternative pathway allowed by this chemistry. Synthesis and characterization, with infrared (IR), 1 H and 13 C NMR spectroscopies, high-resolution mass spectrometry, gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA), are reported for these divergently grown dendrimers.

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“…The hydrolysis is realized by the unique collaboration between Histidine-57 (His-57), and Aspartate-102 (Asp-102) [5]. Intrigued by this performance, several groups have tried to construct model systems with hydrolytic activity and different peptide based systems have been developed in this context [6][7][8][9][10][11][12][13][14][15][16]. We must bear in mind that stable secondary structures such as helices only become important for rather long sequences of polypeptides.…”

Section: Introductionmentioning

confidence: 99%