A strong prognostic variable in endometrial carcinoma

Abstract

RESULTS. The S-phase fraction was identified as the most significant variable associated with death from endometrial carcinoma of endometrioid type by the Cox Department of Obstetrics and Gynecology, Gyproportional hazards model. The risk of death was significantly higher in patients necologic Oncology and Gynecologic Pathology with S-phase values greater than 20%. Aneuploidy and DNA indexes were also Section, Cerrahpas¨a Faculty of Medicine, Ig stansignificant prognostic variables. bul University, Ig stanbul, Turkey.

Molecular pathogenesis and prognostic factors in endometrial carcinoma

“…There are several methods available for measuring the proliferative activity (190,192). S-phase is the part of the cell cycle in which DNA synthesis occurs, and estimation of Sphase fraction by flow cytometry has been of prognostic importance in a number of studies (163,174,186,193). Later, immunohistochemical methods for detection of antigens associated with proliferation have been developed 679 (190,192), allowing determination of proliferative activity with preserved morphology.…”