A Study of Certain Physical and I131-Exchange-Tagging Characteristics of Iodopropylidene Glycerol**Department of Chemistry, Philadelphia College of Pharmacy and Science

Paper Chromatography Of I131-Labeled Iodopropylidene Glycerol With Autoradiographic Identification**Department of Chemistry, Philadelphia College of Pharmacy and Science

“…Duplicate chromatograms were run using each solvent, and in those cases where more than one spot was obtained another pair of duplicates were obtained. The appearance of multiple spots is not surprising in view of the fact that two structural isomers of IPG, differing in the position of the iodine atom in the molecule, are present, and that a theoretical total of 12 optical stereoisomers may be present, which latter, however, have not been characterized (2).…”

“…along lines described by Williams and Kirby (7), was chosen for this work. The IPG, tagged with IlJ1 by an exchange method (2), was applied to the paper as a solution in chloroform. The amount of IPG applied to the paper was determined from counts of total radioactivity obtained with the scanning equipment before the chromatography was begun.…”

“…Tdeveloping suitable analytical techniques to be used in certain phases of a n investigation of the biological distribution and fate of iodopropylidene glycerol (1,2), hereafter referred to as IPG, a safe and orally efficacious source1 of iodine for nutritional and therapeutic use in humans (3)(4)(5)(6).…”