Paper Chromatography Of I131-Labeled Iodopropylidene Glycerol With Autoradiographic Identification**Department of Chemistry, Philadelphia College of Pharmacy and Science

Hoffnagle, George F.; Sideri, Catherine N.; Osol, Arthur

doi:10.1002/jps.3030470504

Cited by 3 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…portions of chloroform, thereby indicating that no appreciable portion of the radioactivity was present as iodide. Furthermore, paper chromatograms (5) showed no detectable iodide, iodate, or free iodine. The total iodine content in the final solutions was determined by alkaline digestion followed by titration with 0.01 N silver nitrate.…”

Section: By George F Hoffnaglet and Arthur Osolmentioning

confidence: 99%

See 1 more Smart Citation

A Study of Certain Physical and I131-Exchange-Tagging Characteristics of Iodopropylidene Glycerol**Department of Chemistry, Philadelphia College of Pharmacy and Science

Hoffnagle¹,

Osol

1958

Journal of the American Pharmaceutical Association (Scientific

Self Cite

View full text Add to dashboard Cite

Section: By George F Hoffnaglet and Arthur Osolmentioning

confidence: 99%

“…This information was used to produce tagged IPG of high specific activities for chromatographic (5) and biological (6) Table IV. York, 1957. x + 262 pp.…”

Section: By George F Hoffnaglet and Arthur Osolmentioning

confidence: 99%

A Study of Certain Physical and I131-Exchange-Tagging Characteristics of Iodopropylidene Glycerol**Department of Chemistry, Philadelphia College of Pharmacy and Science

Hoffnagle¹,

Osol

1958

Journal of the American Pharmaceutical Association (Scientific

Self Cite

View full text Add to dashboard Cite

Identification of Components in Iodinated Glycerol

Cannon

Brown

Murrill

et al. 1989

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Iodinated glycerol (CAS no. 5634-39-9), therapeutically used as an expectorant and source of organically bound iodine, was analyzed to determine the purity and composition of the chemical samples used in carcinogenicity and toxicity studies. The manufactured product is described by the patent and chemical literature as a mixture of two isomeric iodopropylideneglycerols (structures 1 and 2). The results of our studies, however, indicate that the two principal components of the product were 3-iodo-1,2-propanediol (IPD) and glycerol (GLY). Analyses from GC-MS (full scan electron impact) and carbon-13 nuclear magnetic resonance spectrometry provided conclusive identification of these components. The quantification of IPD and GLY in one of two samples of commercial product using GC-flame ionization detection indicated concentrations of 33 and 17%, respectively (Sample A). Similar concentrations were determined for a second sample from the same source (Sample B), which was a gratis sample procured approximately nine years after Sample A. Numerous minor components were also observed in these two samples. These components were tentatively identified as condensation products of glycerol and iodine-containing analogues. The iodopropylideneglycerol compounds, described in the patent, were not observed in either of the two samples.

show abstract

The Distribution and Fate of Iodine in Iodopropylidene Glycerol in the Rat**Department of Chemistry, Philadelphia College of Pharmacy and Science

Hoffnagle¹,

Osol

1958

Journal of the American Pharmaceutical Association (Scientific

View full text Add to dashboard Cite

Paper Chromatography Of I131-Labeled Iodopropylidene Glycerol With Autoradiographic Identification**Department of Chemistry, Philadelphia College of Pharmacy and Science

Cited by 3 publications

References 4 publications

A Study of Certain Physical and I131-Exchange-Tagging Characteristics of Iodopropylidene Glycerol**Department of Chemistry, Philadelphia College of Pharmacy and Science

A Study of Certain Physical and I131-Exchange-Tagging Characteristics of Iodopropylidene Glycerol**Department of Chemistry, Philadelphia College of Pharmacy and Science

Identification of Components in Iodinated Glycerol

The Distribution and Fate of Iodine in Iodopropylidene Glycerol in the Rat**Department of Chemistry, Philadelphia College of Pharmacy and Science

Contact Info

Product

Resources

About